scholarly journals The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Masoumeh Faghani ◽  
Saba Fakhrieh Asl ◽  
Fariborz Mansour-Ghanaei ◽  
Keyvan Aminian ◽  
Alireza Tarang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Positive Family History ◽  
Tumor Location ◽  
Sporadic Colorectal Cancer ◽  
The North ◽  
Distal Tumor ◽  
North Part ◽  
History Of ◽  
Guilan Province

Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran.Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers.Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (P=0.04, odds ratio = 3.13, 0.96–10.14).Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer

2007 ◽  
Vol 248 (2) ◽  
pp. 262-268 ◽  
Author(s):  
Richard G. Stevens ◽  
Helen Swede ◽  
Christopher D. Heinen ◽  
Melissa Jablonski ◽  
Michael Grupka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Positive Family History ◽  
Aberrant Crypt Foci ◽  
Sporadic Colorectal Cancer ◽  
History Of

scholarly journals The Association of Tumor Microsatellite Instability Phenotype with Family History of Colorectal Cancer

2009 ◽  
Vol 18 (3) ◽  
pp. 967-975 ◽  
Author(s):  
Bharati Bapat ◽  
Noralane M. Lindor ◽  
John Baron ◽  
Kim Siegmund ◽  
Lin Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Microsatellite Instability ◽  
History Of ◽  
Instability Phenotype

scholarly journals Distinct BRAF (V600E) and KRAS Mutations in High Microsatellite Instability Sporadic Colorectal Cancer in African Americans

2009 ◽  
Vol 15 (4) ◽  
pp. 1155-1161 ◽  
Author(s):  
Krishan Kumar ◽  
Hassan Brim ◽  
Francis Giardiello ◽  
Duane T. Smoot ◽  
Mehdi Nouraie ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
African Americans ◽  
Microsatellite Instability ◽  
Braf V600e ◽  
Sporadic Colorectal Cancer ◽  
Kras Mutations

scholarly journals Screeners vs. Non-screeners for Colorectal Cancer among People over 50 Years of Age: Factual and Psychological Discriminants

2020 ◽  
Author(s):  
Andrada Ciucă ◽  
Ramona Moldovan ◽  
Sebastian Pintea ◽  
Dan Dumitrașcu ◽  
Adriana Băban
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Positive Family History ◽  
Psychosocial Interventions ◽  
The Elderly ◽  
Roc Curve Analysis ◽  
Convenience Sample ◽  
Colonoscopy Screening ◽  
History Of ◽  
D Values

Background and Aims: Colorectal cancer (CRC) is the third most frequent form of cancer worldwide, and approximately one third of cases have a positive family history of CRC or associated cancers. Colonoscopy is one of the most effective methods of screening for CRC. Uptake of colonoscopy is suboptimal, and many countries lack a national screening programme. Our study aims at exploring and ranking several factual and psychological variables according to their accuracy in discriminating between screeners and non-screeners for CRC in a convenience sample of people over 50 years of age. Methods: The study included 103 individuals aged over 50 years, recruited from day centres for the elderly. We explored socio-demographic variables, frequency of colonoscopy, previous recommendations for screening, health literacy and family history of cancer. Receiver operating characteristic (ROC) analysis was used to establish the discriminative value for each variable between the positive and negative decision for colonoscopy screening. Areas under the curve (AUC) and their equivalent Cohen‘s d values were calculated. Results: Almost a quarter (25.75%) of participants reported previous colonoscopy screening. ROC curve analysis shows that colonoscopy uptake is best discriminated by perceived benefits of screening (AUC=0.71, d=0.78, p<0.001), previous recommendations for screening (AUC=0.68, d=0.69, p<0.001) and previous recommendations for preventive measures (AUC=0.67, d=0.64, p<0.001). Conclusions: Recommendations from healthcare professionals lead to improved colonoscopy uptake when emphasising the benefits of screening. Results can further inform psychosocial interventions by bringing empirical evidence to emphasize screening benefits and explicit recommendations for individuals at risk for CRC cancer.

scholarly journals Family History of Colorectal Cancer Is Not Associated with Colorectal Cancer Survival Regardless of Microsatellite Instability Status

2014 ◽  
Vol 23 (8) ◽  
pp. 1700-1704 ◽  
Author(s):  
Amanda I. Phipps ◽  
Dennis J. Ahnen ◽  
Peter T. Campbell ◽  
Aung Ko Win ◽  
Mark A. Jenkins ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Microsatellite Instability ◽  
Cancer Survival ◽  
Colorectal Cancer Survival ◽  
History Of

Adenoma incidence after resection of sporadic colorectal cancer with microsatellite instability

2010 ◽  
Vol 101 (7) ◽  
pp. 577-581 ◽  
Author(s):  
Ki Joo Kang ◽  
Dong Hyun Sinn ◽  
Sung Hyun Park ◽  
Jin Yong Kim ◽  
Dong Kyung Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Sporadic Colorectal Cancer
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