A positive family history of cancer or lifestyle factors may not explain the high incidence of early-onset colorectal cancer in India

2014 ◽  
Vol 3 (5) ◽  
pp. 409-416
Author(s):  
Ratheesh Raman ◽  
Viswakalyan Kotapalli ◽  
Mohana Vamsy ◽  
Sujit C Patnaik ◽  
Mukta Srinivasulu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Early Onset ◽  
Positive Family History ◽  
Lifestyle Factors ◽  
Family History Of Cancer ◽  
High Incidence ◽  
History Of ◽  
Early Onset Colorectal Cancer ◽  
History Of Cancer

Risk factors for early-onset colorectal cancer in China.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10542-10542
Author(s):  
Zhe Pan ◽  
Junfeng Huang ◽  
Mingkai Huang ◽  
Zhiyuan Yao ◽  
Jiongqiang Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cohort Study ◽  
Family History ◽  
Early Onset ◽  
Cancer Site ◽  
Family History Of Cancer ◽  
History Of ◽  
Early Onset Colorectal Cancer ◽  
History Of Cancer

10542 Background: The incidence of colorectal cancer among persons aged < 50 years (early-onset colorectal cancer, EOCRC) has increased since the early 1990s. However, the risk factors contributing to this trend remain largely unknown. Methods: We conducted a retrospective study of participants who were aged < 50 years and without a previous cancer history, using the China Kadoorie Biobank cohort study. We analyzed data related to demographics, lifestyle habits, family history, and comorbidities of EOCRC cases with participants without colorectal cancer in this age group (controls). Univariate and multivariate-adjusted cox regression models were used to estimate the associations with risk factors. Results: We identified 225 EOCRC cases and 88842 controls that include the final analyses. Of the 225 EOCRC patients, 105 (46.7%) were colon cancers and 120 (53.3%) were rectum cancers. EOCRC cases were older, have more intake of fish and eggs, have higher BMIs, diabetes, and family history of cancer compared with controls (P < 0.05). After adjustment for potential confounding factors, increasing age (HR 2.18, 95%CI 2.05-2.31), BMI (HR 1.06, 95%CI 1.01-1.11), family history of cancer (HR 1.41, 95%CI 1.00-1.98), and more intake of fish (HR 1.54, 95%CI 1.09-2.19) were significantly associated with a higher risk of EOCRC. In sensitivity analyses stratified by cancer site (colon and rectum), the results remained consistent. Conclusions: Based on the large Chinese cohort study, we found increasing age, higher BMI or obesity, family history of cancer, and more intake of fish were independent risk factors for EOCRC. Further studies are needed to identify factors that cause the increasing incidence of EOCRC in China and other countries, and explore the potential mechanism behind.[Table: see text]

scholarly journals Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 631
Author(s):  
Karin Alvarez ◽  
Alessandra Cassana ◽  
Marjorie De La Fuente ◽  
Tamara Canales ◽  
Mario Abedrapo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Age Of Onset ◽  
Late Onset ◽  
Molecular Characteristics ◽  
Family History Of Cancer ◽  
Molecular Features ◽  
Age Of Diagnosis ◽  
History Of ◽  
History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

scholarly journals The Leptin Gene Family and Colorectal Cancer: Interaction with Smoking Behavior and Family History of Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60777 ◽  
Author(s):  
Li Liu ◽  
Rong Zhong ◽  
Sheng Wei ◽  
Hao Xiang ◽  
Jigui Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Gene Family ◽  
Smoking Behavior ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

2015 ◽  
Vol 60 (2) ◽  
pp. 223-228 ◽  
Author(s):  
Ticiana M. Sabóia ◽  
Maria Fernanda Reis ◽  
Ângela M.C. Martins ◽  
Helena F. Romanos ◽  
Patricia N. Tannure ◽  
...  
Keyword(s):  
Family History ◽  
Positive Family History ◽  
Oral Clefts ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer

Increased Risk Of Brain Tumors Among First-Degree Relatives Of Patients With Therapy-Related Myelodysplasia and Acute Myeloid Leukemia (t-MDS/AML)

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5228-5228
Author(s):  
Patrick Halliday ◽  
Alysia Bosworth ◽  
Can-Lan Sun ◽  
Tongjun Kang ◽  
Lindsey Hageman ◽  
...  
Keyword(s):  
Family History ◽  
Brain Tumors ◽  
Hodgkin Lymphoma ◽  
Positive Family History ◽  
Individual Variability ◽  
Excess Risk ◽  
Family History Of Cancer ◽  
First Degree Relatives ◽  
History Of ◽  
History Of Cancer

Abstract Background t-MDS/AML is a leading cause of non-relapse mortality among patients undergoing autologous hematopoietic cell transplantation (aHCT) for Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A combination of therapeutic exposures prior to aHCT, aHCT-related conditioning regimens, peripheral blood stem cell mobilization and post-aHCT hematopoietic regeneration contribute to the development of t-MDS/AML. However, significant inter-individual variability is observed despite similar therapeutic exposures. This inter-individual variability could possibly be explained by low-penetrance, high-prevalence polymorphisms in genes involved in DNA damage and repair. On the other hand, a small but quantifiable fraction of the inter-individual variability observed in the risk of t-MDS/AML (in the context of comparable genotoxic exposures) could be attributable to the familial predisposition to cancer that is associated with rare polymorphisms in high-penetrance genes – an area that has not been explored thus far. Methods This study aimed to describe the excess risk of specific cancers among first-degree relatives of HL/NHL patients with t-MDS/AML after aHCT compared to first-degree relatives of HL/NHL patients without t-MDS/AML. We have constructed a prospective, longitudinal cohort of patients undergoing aHCT for HL and NHL, where patients are followed from pre-aHCT to 10 yrs post-aHCT (period of risk for t-MDS/AML) allowing for complete ascertainment of t-MDS/AML cases. Study participants were invited to complete a family history questionnaire. Probands with at least one sibling, parent or offspring with cancer were defined as having a positive family history of cancer. Person-yrs at risk for the cohort of relatives were determined from birth to the development of cancer, death or date of questionnaire completion (whichever occurred first). Person-yrs at risk were stratified by age, sex and calendar yr and applied to SEER registry data to yield expected numbers of each type of cancer to compute standardized incidence ratios (SIR: observed/expected) with 95% confidence intervals (CI) for cancer incidence in first-degree relatives of probands with and without t-MDS/AML. Results The 446 HL/NHL patients in the cohort reported on 2,664 first-degree relatives, yielding 130,578 person-yrs of follow up. A positive family history of cancer was reported by 103 patients, with 370 incidences of cancer. When stratified by t-MDS/AML status, a positive family history of cancer was identified in 15 of 64 patients with t-MDS/AML (23%) vs. 88 of 382 (23%) patients without t-MDS/AML, yielding an overall SIR of 1.09 (0.82-1.42) for relatives of HL/NHL patients with t-MDS/AML vs. 1.01 (0.89-1.13) for relatives of HL/NHL patients without t-MDS/AML (p=0.60) (Table). However, examination of risk by family history of specific cancer type demonstrated an excess risk of brain tumors among relatives of HL/NHL patients with t-MDS/AML (SIR=5.27, 95% CI, 1.89-11.31) as opposed to relatives of lymphoma patients without t-MDS/AML (SIR=1.55, 95% CI, 0.71-2.89, p=0.03) (Table). This excess risk was contributed to largely by brain tumors among fathers of patients with t-MDS/AML (SIR=5.84, 95% CI, 0.97-18.05) when compared with fathers of patients without t-MDS/AML (SIR=1.05, 95% CI, 0.18-3.27, p=0.09). Conclusions This study demonstrates an excess risk of brain tumors among first-degree relatives (and in particular fathers) of HL/NHL patients with t-MDS/AML after aHCT, as compared to HL/NHL patients without t-MDS/AML. This information may serve as a basis for the discovery of underlying genetic predisposition syndromes as well as specific genes responsible for their development. Disclosures: No relevant conflicts of interest to declare.

Race and Colorectal Cancer Screening Compliance Among Persons With a Family History of Cancer

2015 ◽  
Vol 110 ◽  
pp. S611-S612
Author(s):  
Adeyinka O. Laiyemo ◽  
Nicole Thompson ◽  
Carla Williams ◽  
Kolapo Idowu ◽  
Kathy P. Bull-Henry ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Family History ◽  
Colorectal Cancer Screening ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer
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