The long-term effects of febrile seizures on the hippocampal neuronal plasticity – Clinical and experimental evidence

2009 ◽  
Vol 31 (5) ◽  
pp. 383-387 ◽  
Author(s):  
Chao-Ching Huang ◽  
Ying-Chao Chang
Keyword(s):  
Experimental Evidence ◽  
Neuronal Plasticity ◽  
Febrile Seizures ◽  
Long Term Effects

scholarly journals Experimental evidence of the long‐term effects of reindeer on Arctic vegetation greenness and species richness at a larger landscape scale

2019 ◽  
Vol 107 (6) ◽  
pp. 2724-2736 ◽  
Author(s):  
Maja K. Sundqvist ◽  
Jon Moen ◽  
Robert G. Björk ◽  
Tage Vowles ◽  
Minna‐Maarit Kytöviita ◽  
...  
Keyword(s):  
Species Richness ◽  
Experimental Evidence ◽  
Landscape Scale ◽  
Long Term Effects ◽  
Vegetation Greenness ◽  
Arctic Vegetation

Nutrition, weight gain and eating behavior in pregnancy: A review of experimental evidence for long-term effects on the risk of obesity in offspring

2012 ◽  
Vol 107 (1) ◽  
pp. 138-145 ◽  
Author(s):  
Sarbattama Sen ◽  
Arielle H. Carpenter ◽  
Jessica Hochstadt ◽  
Juli Y. Huddleston ◽  
Vladimir Kustanovich ◽  
...  
Keyword(s):  
Weight Gain ◽  
Experimental Evidence ◽  
Eating Behavior ◽  
Long Term Effects ◽  
In Pregnancy

scholarly journals Febrile Seizures: Current Views and Investigations

2009 ◽  
Vol 36 (6) ◽  
pp. 679-686 ◽  
Author(s):  
Aylin Y. Reid ◽  
Michael A. Galic ◽  
G. Campbell Teskey ◽  
Quentin J. Pittman
Keyword(s):  
Animal Models ◽  
Current Literature ◽  
Growth And Development ◽  
Animal Studies ◽  
Pediatric Population ◽  
Febrile Seizures ◽  
Long Term Effects ◽  
Common Cause ◽  
Increased Risk

Febrile seizures (FSs) are seizures that occur during fever, usually at the time of a cold or flu, and represent the most common cause of seizures in the pediatric population. Up to 5% of children between the ages of six months and five years-of-age will experience a FS. Clinically these seizures are categorized as benign events with little impact on the growth and development of the child. However, studies have linked the occurrence of FSs to an increased risk of developing adult epileptic disorders. There are many unanswered questions about FSs, such as the mechanism of their generation, the long-term effects of these seizures, and their role in epileptogenesis. Answers are beginning to emerge based on results from animal studies. This review summarizes the current literature on animal models of FSs, mechanisms underlying the seizures, and functional, structural, and molecular changes that may result from them.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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