scholarly journals Orbital and Medial Prefrontal Cortex Functional Connectivity of Major Depression Vulnerability and Disease

2018 ◽  
Vol 3 (4) ◽  
pp. 348-357 ◽  
Author(s):  
Zoe Samara ◽  
Elisabeth A.T. Evers ◽  
Frenk Peeters ◽  
Harry B.M. Uylings ◽  
Grazyna Rajkowska ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Functional Connectivity ◽  
Medial Prefrontal Cortex ◽  
Depression Vulnerability

Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity

2019 ◽  
Vol 216 (5) ◽  
pp. 267-274 ◽  
Author(s):  
Shu Liu ◽  
Ang Li ◽  
Yong Liu ◽  
Hao Yan ◽  
Meng Wang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Medial Prefrontal Cortex ◽  
Grey Matter ◽  
Grey Matter Volume ◽  
Polygenic Risk Score ◽  
Polygenic Inheritance ◽  
Polygenic Risk ◽  
Matter Volume ◽  
A Genome

BackgroundSchizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated.AimsTo investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia.MethodGenomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant.ResultsThe imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia.ConclusionsThese findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia.

scholarly journals SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex

2011 ◽  
Vol 16 (6) ◽  
pp. 592-594 ◽  
Author(s):  
C McCabe ◽  
Z Mishor ◽  
N Filippini ◽  
P J Cowen ◽  
M J Taylor ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Medial Prefrontal Cortex ◽  
Resting State ◽  
Resting State Functional Connectivity
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