scholarly journals Childhood Trauma and Functional Connectivity between Amygdala and Medial Prefrontal Cortex: A Dynamic Functional Connectivity and Large-Scale Network Perspective

2017 ◽  
Vol 11 ◽  
Author(s):  
Josh M. Cisler
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Childhood Trauma ◽  
Medial Prefrontal Cortex ◽  
Large Scale ◽  
Dynamic Functional Connectivity ◽  
Large Scale Network ◽  
Scale Network

scholarly journals Resting-state functional connectivity and quantitation of glutamate and GABA of the PCC/precuneus by magnetic resonance spectroscopy at 7T in healthy individuals

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244491
Author(s):  
Ofer M. Gonen ◽  
Bradford A. Moffat ◽  
Patrick Kwan ◽  
Terence J. O’Brien ◽  
Patricia M. Desmond ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Magnetic Resonance Spectroscopy ◽  
Large Scale ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Disease States ◽  
Large Scale Network ◽  
Age Related ◽  
Scale Network

The default mode network (DMN) is the main large-scale network of the resting brain and the PCC/precuneus is a major hub of this network. Glutamate and GABA (γ-amino butyric acid) are the main excitatory and inhibitory neurotransmitters in the CNS, respectively. We studied glutamate and GABA concentrations in the PCC/precuneus via magnetic resonance spectroscopy (MRS) at 7T in relation to age and correlated them with functional connectivity between this region and other DMN nodes in ten healthy right-handed volunteers ranging in age between 23–68 years. Mean functional connectivity of the PCC/precuneus to the other DMN nodes and the glutamate/GABA ratio significantly correlated with age (r = 0.802, p = 0.005 and r = 0.793, p = 0.006, respectively) but not with each other. Glutamate and GABA alone did not significantly correlate with age nor with functional connectivity within the DMN. The glutamate/GABA ratio and functional connectivity of the PCC/precuneus are, therefore, independent age-related biomarkers of the DMN and may be combined in a multimodal pipeline to study DMN alterations in various disease states.

scholarly journals Large-scale network organization of EEG functional connectivity in newborn infants

2017 ◽  
Vol 38 (8) ◽  
pp. 4019-4033 ◽  
Author(s):  
Brigitta Tóth ◽  
Gábor Urbán ◽  
Gábor P. Háden ◽  
Molnár Márk ◽  
Miklós Török ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Large Scale ◽  
Newborn Infants ◽  
Network Organization ◽  
Large Scale Network ◽  
Scale Network ◽  
Eeg Functional Connectivity

scholarly journals Inferring Functional Connectivity From Time-Series of Events in Large Scale Network Deployments

2019 ◽  
Vol 16 (3) ◽  
pp. 857-870
Author(s):  
Antoine Messager ◽  
George Parisis ◽  
Istvan Z. Kiss ◽  
Robert Harper ◽  
Phil Tee ◽  
...  
Keyword(s):  
Time Series ◽  
Functional Connectivity ◽  
Large Scale ◽  
Large Scale Network ◽  
Scale Network

scholarly journals A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms

2019 ◽  
Vol 22 ◽  
pp. 101739 ◽  
Author(s):  
Leah M. Fleming ◽  
Daniel C. Javitt ◽  
Cameron S. Carter ◽  
Joshua T. Kantrowitz ◽  
Ragy R. Girgis ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Multicenter Study ◽  
Large Scale ◽  
Large Scale Network ◽  
Scale Network
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