scholarly journals Hydrophobic Characteristic Is Energetically Preferred for Cysteine in a Model Membrane Protein

2019 ◽  
Vol 117 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Bharat Ramasubramanian Iyer ◽  
Radhakrishnan Mahalakshmi
Keyword(s):  
Membrane Protein ◽  
Model Membrane

scholarly journals Computer simulation of the phase behavior of a model membrane protein: Annexin V

2002 ◽  
Vol 116 (16) ◽  
pp. 7217-7224 ◽  
Author(s):  
Martin A. Bates ◽  
Massimo G. Noro ◽  
Daan Frenkel
Keyword(s):  
Computer Simulation ◽  
Membrane Protein ◽  
Phase Behavior ◽  
Annexin V ◽  
Model Membrane

Interaction of drugs with a model membrane protein

1982 ◽  
Vol 31 (4) ◽  
pp. 527-534 ◽  
Author(s):  
Michael A. Singer
Keyword(s):  
Membrane Protein ◽  
Model Membrane

scholarly journals Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry

2021 ◽  
Author(s):  
Marius Kostelic ◽  
Ciara K. Zak ◽  
Hiruni Jayasekera ◽  
Michael Marty
Keyword(s):  
Mass Spectrometry ◽  
Membrane Protein ◽  
Lipid Bilayers ◽  
Biological Membranes ◽  
Native Mass Spectrometry ◽  
Model Membrane ◽  
Peptide Interactions ◽  
Lipid Nanodiscs ◽  
Natural Lipid ◽  
Selection Of

Native mass spectrometry (MS) with nanodiscs is a promising technique for characterizing membrane protein and peptide interactions in lipid bilayers. However, prior studies have used nanodiscs made of only one or two lipids, which lack the complexity of a natural lipid bilayer. To better model specific biological membranes, we developed model mammalian, bacterial, and mitochondrial nanodiscs with up to four different phospholipids. Careful selection of lipids with similar masses that balance the fluidity and curvature enabled these complex nanodiscs to be assembled and resolved with native MS. We then applied this approach to characterize the specificity and incorporation of LL-37, a human antimicrobial peptide, in single lipid nanodiscs versus model bacterial nanodiscs. Overall, development of these model membrane nanodiscs reveals new insights into the assembly of complex nanodiscs and provides a useful toolkit for studying membrane protein, peptide, and lipid interactions in model biological membranes.

Interaction of drugs with a model membrane protein

1980 ◽  
Vol 29 (19) ◽  
pp. 2651-2655 ◽  
Author(s):  
Michael A. Singer
Keyword(s):  
Membrane Protein ◽  
Model Membrane

scholarly journals Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification

Lab on a Chip ◽  
2017 ◽  
Vol 17 (17) ◽  
pp. 2951-2959 ◽  
Author(s):  
James H. Wade ◽  
Joshua D. Jones ◽  
Ivan L. Lenov ◽  
Colleen M. Riordan ◽  
Stephen G. Sligar ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Model Membrane ◽  
Microfluidic Platform ◽  
Membrane Interfaces ◽  
Protein Incorporation

A microfluidic platform for Nanodisc formation and membrane protein incorporation will enable studies of interactions at model membrane interfaces.

scholarly journals The gramicidin ion channel: A model membrane protein

2007 ◽  
Vol 1768 (9) ◽  
pp. 2011-2025 ◽  
Author(s):  
Devaki A. Kelkar ◽  
Amitabha Chattopadhyay
Keyword(s):  
Membrane Protein ◽  
Ion Channel ◽  
Model Membrane
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