scholarly journals Computer simulation of the phase behavior of a model membrane protein: Annexin V

2002 ◽  
Vol 116 (16) ◽  
pp. 7217-7224 ◽  
Author(s):  
Martin A. Bates ◽  
Massimo G. Noro ◽  
Daan Frenkel
Keyword(s):  
Computer Simulation ◽  
Membrane Protein ◽  
Phase Behavior ◽  
Annexin V ◽  
Model Membrane

scholarly journals Computer simulation of copolymer phase behavior

2002 ◽  
Vol 117 (22) ◽  
pp. 10329-10338 ◽  
Author(s):  
Andrew J. Schultz ◽  
Carol K. Hall ◽  
Jan Genzer
Keyword(s):  
Computer Simulation ◽  
Phase Behavior

Phase Behavior of a Designed Cyclopropyl Analogue of Monoolein: Implications for Low-Temperature Membrane Protein Crystallization

2014 ◽  
Vol 127 (3) ◽  
pp. 1041-1045 ◽  
Author(s):  
Livia Salvati Manni ◽  
Alexandru Zabara ◽  
Yazmin M. Osornio ◽  
Jendrik Schöppe ◽  
Alexander Batyuk ◽  
...  
Keyword(s):  
Low Temperature ◽  
Membrane Protein ◽  
Phase Behavior ◽  
Protein Crystallization ◽  
Membrane Protein Crystallization

Interaction of drugs with a model membrane protein

1982 ◽  
Vol 31 (4) ◽  
pp. 527-534 ◽  
Author(s):  
Michael A. Singer
Keyword(s):  
Membrane Protein ◽  
Model Membrane

Phase Behavior of a Designed Cyclopropyl Analogue of Monoolein: Implications for Low-Temperature Membrane Protein Crystallization

2014 ◽  
Vol 54 (3) ◽  
pp. 1027-1031 ◽  
Author(s):  
Livia Salvati Manni ◽  
Alexandru Zabara ◽  
Yazmin M. Osornio ◽  
Jendrik Schöppe ◽  
Alexander Batyuk ◽  
...  
Keyword(s):  
Low Temperature ◽  
Membrane Protein ◽  
Phase Behavior ◽  
Protein Crystallization ◽  
Membrane Protein Crystallization

scholarly journals Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry

2021 ◽  
Author(s):  
Marius Kostelic ◽  
Ciara K. Zak ◽  
Hiruni Jayasekera ◽  
Michael Marty
Keyword(s):  
Mass Spectrometry ◽  
Membrane Protein ◽  
Lipid Bilayers ◽  
Biological Membranes ◽  
Native Mass Spectrometry ◽  
Model Membrane ◽  
Peptide Interactions ◽  
Lipid Nanodiscs ◽  
Natural Lipid ◽  
Selection Of

Native mass spectrometry (MS) with nanodiscs is a promising technique for characterizing membrane protein and peptide interactions in lipid bilayers. However, prior studies have used nanodiscs made of only one or two lipids, which lack the complexity of a natural lipid bilayer. To better model specific biological membranes, we developed model mammalian, bacterial, and mitochondrial nanodiscs with up to four different phospholipids. Careful selection of lipids with similar masses that balance the fluidity and curvature enabled these complex nanodiscs to be assembled and resolved with native MS. We then applied this approach to characterize the specificity and incorporation of LL-37, a human antimicrobial peptide, in single lipid nanodiscs versus model bacterial nanodiscs. Overall, development of these model membrane nanodiscs reveals new insights into the assembly of complex nanodiscs and provides a useful toolkit for studying membrane protein, peptide, and lipid interactions in model biological membranes.

scholarly journals Marginally compact phase and ordered ground states in a model polymer with side spheres

2021 ◽  
Author(s):  
Tatjana Skrbic ◽  
Trinh Xuan Hoang ◽  
Achille Giacometti ◽  
Amos Maritan ◽  
Jayanth R. Banavar
Keyword(s):  
Computer Simulation ◽  
Phase Behavior ◽  
Polymer Chain ◽  
Quantitative Study ◽  
Low Temperatures ◽  
Ground States ◽  
First Order ◽  
Simulation Techniques ◽  
Computer Simulation Techniques ◽  
Mere Addition

We present the results of a quantitative study of the phase behavior of a model polymer chain with side spheres using two independent computer simulation techniques. We find that the mere addition of side spheres results in key modifications of standard polymer behavior. One obtains a novel marginally compact phase at low temperatures, the structures in this phase are reduced in dimensionality and are ordered, they include strands assembled into sheets and a variety of helices, and at least one of the transitions on lowering the temperature to access these ordered states is found to be first order. Our model serves to partially bridge conventional polymer phases with biomolecular phases.

Interaction of drugs with a model membrane protein

1980 ◽  
Vol 29 (19) ◽  
pp. 2651-2655 ◽  
Author(s):  
Michael A. Singer
Keyword(s):  
Membrane Protein ◽  
Model Membrane
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