Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions

Bone ◽  
2014 ◽  
Vol 60 ◽  
pp. 33-40 ◽  
Author(s):  
O. Kos ◽  
R.L. Hughson ◽  
D.A. Hart ◽  
G. Clément ◽  
P. Frings-Meuthen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Elevated Serum ◽  
Bed Rest ◽  
Surrogate Markers

scholarly journals Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

Bone ◽  
2010 ◽  
Vol 46 (1) ◽  
pp. 137-147 ◽  
Author(s):  
Jörn Rittweger ◽  
Gisela Beller ◽  
Gabriele Armbrecht ◽  
Edwin Mulder ◽  
Björn Buehring ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bed Rest ◽  
Vibration Exercise ◽  
Prevention Of Bone Loss

scholarly journals Intravenous Pamidronate Prevents Femoral Bone Loss and Renal Stone Formation During 90-Day Bed Rest

2004 ◽  
Vol 19 (11) ◽  
pp. 1771-1778 ◽  
Author(s):  
Yukiko Watanabe ◽  
Hiroshi Ohshima ◽  
Koh Mizuno ◽  
Chiharu Sekiguchi ◽  
Masao Fukunaga ◽  
...  
Keyword(s):  
Bone Loss ◽  
Renal Stone ◽  
Stone Formation ◽  
Bed Rest ◽  
Femoral Bone ◽  
Intravenous Pamidronate

Association Between Alveolar Bone Loss and Elevated Serum C-Reactive Protein in Japanese Men

2003 ◽  
Vol 74 (12) ◽  
pp. 1741-1746 ◽  
Author(s):  
Toshiyuki Saito ◽  
Masatoshi Murakami ◽  
Yoshihiro Shimazaki ◽  
Kyoko Oobayashi ◽  
Sumihisa Matsumoto ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Elevated Serum ◽  
Alveolar Bone Loss ◽  
C Reactive Protein ◽  
Japanese Men ◽  
Reactive Protein

scholarly journals Circulating microRNAs Correlated with Bone Loss Induced by 45 Days of Bed Rest

2017 ◽  
Vol 8 ◽  
Author(s):  
Shukuan Ling ◽  
Guohui Zhong ◽  
Weijia Sun ◽  
Fengji Liang ◽  
Feng Wu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bed Rest ◽  
Circulating Micrornas

Effect of zoledronic acid on bone loss by letrozole

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 11077-11077
Author(s):  
S. S. Jung ◽  
S. Cha ◽  
J. Bae ◽  
W. Park ◽  
Y. Seo ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Treatment Group ◽  
Bone Resorption ◽  
Bone Loss ◽  
Serum Calcium ◽  
Aromatase Inhibitors ◽  
Surrogate Markers ◽  
Serum Osteocalcin ◽  
Markers Of Bone Resorption ◽  
Microscopic Findings

11077 Background: The aromatase inhibitors cause bone loss by estrogen depletion. Zoledronic acid (ZA) can prevent bone mineral density (BMD) loss associated with the use of aromatase inhibitors. Accordingly interest has arisen in measuring surrogate markers of bone resorption to monitor the response of treatment of BMD loss in place of radiologic assessment. This study was designed to determine whether ZA would prevent bone loss that is known to occur with letrozole and identified surrogate markers of bone resorption in an animal model. Methods: In ovariectomized or sham-operated rat, we administrated ZA and letrozole to 5 different groups including: a sham operation control group (OC), a group in which an ovariectomy was performed followed by saline administration (OS), an ovariectomy with ZA treatment group (OZ), an ovariectomy with letrozole treatment group (OL) and an; ovariectomy with ZA and letrozole combined treatment group (OZL). The levels of serum osteocalcin, serum bone alkaline phosphatase (BALP), serum calcium and urine N-telopeptide (NTX) and BMD were estimated and compared at the same periods for each group. The distinct microscopic findings of proximal tibia at week sixteen were also compared. Results: Significantly intense increment of BDM in the OZ group and the OZL group and lower increment in the OL group were valued in correlation to the OS group, 31.3%, 35.0%, 10.5% and 13.0% respectively. Serum osteocalcin levels and urine calcium levels were close to each group. Serum calcium levels and BALP levels were relatively lowering in the OZ group and the OZL group than other group. Meaningfully lower levels of urine NTX were measured in the OZ group and the OZL group, 6.6% and 16.5% respectively. In the OL group levels of urine NTX were rise of 55.9%. Less cancellous bone loss and increase bone trabeculae were noted in the microscopic findings of tibia. Conclusions: The combination treatment with ZA and letrozole are effective in the inhibition of bone resorption and in the maintenance of BMD. Measurement of serum osteocalcin, urine NTX, and BMD, levels are recommended as surrogate markers for determining the response for the treatment of bone loss. No significant financial relationships to disclose.

scholarly journals Natural Calcium Isotopic Composition of Urine as a Marker of Bone Mineral Balance

2007 ◽  
Vol 53 (6) ◽  
pp. 1155-1158 ◽  
Author(s):  
Joseph Skulan ◽  
Thomas Bullen ◽  
Ariel D Anbar ◽  
J Edward Puzas ◽  
Linda Shackelford ◽  
...  
Keyword(s):  
Bone Loss ◽  
Isotopic Composition ◽  
Bone Mineral ◽  
Bed Rest ◽  
Isotopic Analysis ◽  
Urine Samples ◽  
Control Group ◽  
Mineral Density ◽  
Blood Calcium ◽  
Mineral Balance

Abstract Background: We investigated whether changes in the natural isotopic composition of calcium in human urine track changes in net bone mineral balance, as predicted by a model of calcium isotopic behavior in vertebrates. If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. Methods: Calcium isotopic compositions are expressed as δ44Ca, or the difference in parts per thousand between the 44Ca/40Ca of a sample and the 44Ca/40Ca of a standard reference material. δ44Ca was measured in urine samples from 10 persons who participated in a study of the effectiveness of countermeasures to bone loss in spaceflight, in which 17 weeks of bed rest was used to induce bone loss. Study participants were assigned to 1 of 3 treatment groups: controls received no treatment, one treatment group received alendronate, and another group performed resistive exercise. Measurements were made on urine samples collected before, at 2 or 3 points during, and after bed rest. Results: Urine δ44Ca values during bed rest were lower in controls than in individuals treated with alendronate (P <0.05, ANOVA) or exercise (P <0.05), and lower than the control group baseline (P <0.05, t-test). Results were consistent with the model and with biochemical and bone mineral density data. Conclusion: Results confirm the predicted relationship between bone mineral balance and calcium isotopes, suggesting that calcium isotopic analysis of urine might be refined into a clinical and research tool.

scholarly journals Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins

Bone ◽  
2007 ◽  
Vol 40 (2) ◽  
pp. 529-537 ◽  
Author(s):  
Sara R. Zwart ◽  
Alan R. Hargens ◽  
Stuart M.C. Lee ◽  
Brandon R. Macias ◽  
Donald E. Watenpaugh ◽  
...  
Keyword(s):  
Bone Loss ◽  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Identical Twins ◽  
Lower Body

Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment

Bone ◽  
2009 ◽  
Vol 44 (4) ◽  
pp. 612-618 ◽  
Author(s):  
Jörn Rittweger ◽  
Bostjan Simunic ◽  
Giancarlo Bilancio ◽  
Natale Gaspare De Santo ◽  
Massimo Cirillo ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bed Rest ◽  
Lower Leg

Resistive vibration exercise retards bone loss in weight-bearing skeletons during 60 days bed rest

2011 ◽  
Vol 23 (8) ◽  
pp. 2169-2178 ◽  
Author(s):  
H. Wang ◽  
Y. Wan ◽  
K.-F. Tam ◽  
S. Ling ◽  
Y. Bai ◽  
...  
Keyword(s):  
Bone Loss ◽  
Weight Bearing ◽  
Bed Rest ◽  
Vibration Exercise

scholarly journals Bone loss patterns in cortical, subcortical, and trabecular compartments during simulated microgravity

2014 ◽  
Vol 117 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Tomas Cervinka ◽  
Harri Sievänen ◽  
Jari Hyttinen ◽  
Jörn Rittweger
Keyword(s):  
Bone Loss ◽  
Study Design ◽  
Simulated Microgravity ◽  
Loss Rate ◽  
Bed Rest ◽  
Bone Adaptation ◽  
Control Groups ◽  
The Mean ◽  
Skeletal Adaptation ◽  
Bone Loss Rate

Disuse studies provide a useful model for bone adaptation. A direct comparison of these studies is, however, complicated by the different settings used for bone analysis. Through pooling and reanalysis of bone data from previous disuse studies, we determined bone loss and recovery in cortical, subcortical, and trabecular compartments and evaluated whether the study design modulated skeletal adaptation. Peripheral quantitative tomographic (pQCT) images from control groups of four disuse studies with a duration of 24, 35, 56, and 90 days were reanalyzed using a robust threshold-free segmentation algorithm. The pQCT data were available from 27 young healthy men at baseline, and at specified intervals over disuse and reambulation phases. The mean maximum absolute bone loss (mean ± 95% CI) was 6.1 ± 4.5 mg/mm in cortical, 2.4 ± 1.6 mg/mm in subcortical, and 9.8 ± 9.1 mg/mm in trabecular compartments, after 90 days of bed rest. The percentage changes in all bone compartments were, however, similar. During the first few weeks after onset of reambulation, the bone loss rate was systematically greater in the cortical than in the trabecular compartment ( P < 0.002), and this was observed in all studies except for the longest study. We conclude that disuse-induced bone losses follow similar patterns irrespective of study design, and the largest mean absolute bone loss occurs in the cortical compartment, but apparently only during the first 60 days. With longer study duration, trabecular loss may become more prominent.

Sign in / Sign up

Export Citation Format

Share Document