Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment

Bone ◽  
2009 ◽  
Vol 44 (4) ◽  
pp. 612-618 ◽  
Author(s):  
Jörn Rittweger ◽  
Bostjan Simunic ◽  
Giancarlo Bilancio ◽  
Natale Gaspare De Santo ◽  
Massimo Cirillo ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bed Rest ◽  
Lower Leg

scholarly journals Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

Bone ◽  
2010 ◽  
Vol 46 (1) ◽  
pp. 137-147 ◽  
Author(s):  
Jörn Rittweger ◽  
Gisela Beller ◽  
Gabriele Armbrecht ◽  
Edwin Mulder ◽  
Björn Buehring ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bed Rest ◽  
Vibration Exercise ◽  
Prevention Of Bone Loss

Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions

Bone ◽  
2014 ◽  
Vol 60 ◽  
pp. 33-40 ◽  
Author(s):  
O. Kos ◽  
R.L. Hughson ◽  
D.A. Hart ◽  
G. Clément ◽  
P. Frings-Meuthen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Elevated Serum ◽  
Bed Rest ◽  
Surrogate Markers

Therapie der tiefen Venenthrombose mit niedermolekularem Heparin, Beinkompression und sofortigem Gehen

VASA ◽  
2001 ◽  
Vol 30 (3) ◽  
pp. 195-204 ◽  
Author(s):  
H. Partsch
Keyword(s):  
Pulmonary Embolism ◽  
Bed Rest ◽  
Lower Leg ◽  
Bleeding Complications ◽  
Pulmonary Emboli ◽  
Malignant Diseases ◽  
Vein Thrombosis ◽  
Fatal Bleeding ◽  
Lung Scan ◽  
Low Incidence

Background: Traditionally, patients with acute deep vein thrombosis (DVT) are treated with strict bed rest for several days to avoid clots from breaking off and causing pulmonary emboli. The purpose of this study is to give a precise estimate of short term complications like pulmonary embolism, bleeding, heparin-induced thrombocytopenia (HIT) and death in a cohort of consecutive patients who were admitted because of acute symptomatic DVT, all treated by compression and walking exercises instead of conventional bed-rest and nearly all by low-molecular-weight heparin. Patients and methods: In 1289 consecutive patients the following five endpoints were registered for the period of hospital-stay: 1. Frequency of pulmonary embolism (PE ) at admission (V/Q lung scan), 2. Frequency of new PE’s after 10 days (second lung scan), 3. Fatal events (autopsy), 4. Frequency of malignant disease, 5. Bleeding complications and HIT. Results: 1. 190/356 (53.4% of iliofemoral, 355/675 (52.6%) of femoral and 84/239 (35.1%) of lower leg vein thrombosis showed PE (difference iliofemoral and femoral versus lower leg DVT p < 0.001). Two thirds of these PE were asymptomatic. 2. New PE after 10 days in comparison to the baseline scan occurred in 7.4%, 6.4% and 3.4% respectively. 3. Fatal events, all investigated by autopsy, were caused by PE in 3 patients aged over 76 years (0.23%), by malignant diseases in 12 (0.9%) and due to other causes in 2 (0.15%). 4. 232 patients (18%) had associated malignant diseases, from which 33% were detected by our screening. 5. Non-fatal bleeding complications were seen in 3.3%, including 5 patients (0.4%) with major bleeding. Three patients (0,2%) suffered from HIT II. Conclusion: The low incidence of recurrent and fatal pulmonary emboli in this series affirms the value of early ambulation with heavy leg compression in patients with symptomatic acute leg deep venous thrombosis. In addition, the presence of pulmonary emboli in one-third of those with calf vein thrombi emphasizes the importance of fully diagnosing and treating calf clots.

scholarly journals Intravenous Pamidronate Prevents Femoral Bone Loss and Renal Stone Formation During 90-Day Bed Rest

2004 ◽  
Vol 19 (11) ◽  
pp. 1771-1778 ◽  
Author(s):  
Yukiko Watanabe ◽  
Hiroshi Ohshima ◽  
Koh Mizuno ◽  
Chiharu Sekiguchi ◽  
Masao Fukunaga ◽  
...  
Keyword(s):  
Bone Loss ◽  
Renal Stone ◽  
Stone Formation ◽  
Bed Rest ◽  
Femoral Bone ◽  
Intravenous Pamidronate

scholarly journals Circulating microRNAs Correlated with Bone Loss Induced by 45 Days of Bed Rest

2017 ◽  
Vol 8 ◽  
Author(s):  
Shukuan Ling ◽  
Guohui Zhong ◽  
Weijia Sun ◽  
Fengji Liang ◽  
Feng Wu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bed Rest ◽  
Circulating Micrornas

scholarly journals Natural Calcium Isotopic Composition of Urine as a Marker of Bone Mineral Balance

2007 ◽  
Vol 53 (6) ◽  
pp. 1155-1158 ◽  
Author(s):  
Joseph Skulan ◽  
Thomas Bullen ◽  
Ariel D Anbar ◽  
J Edward Puzas ◽  
Linda Shackelford ◽  
...  
Keyword(s):  
Bone Loss ◽  
Isotopic Composition ◽  
Bone Mineral ◽  
Bed Rest ◽  
Isotopic Analysis ◽  
Urine Samples ◽  
Control Group ◽  
Mineral Density ◽  
Blood Calcium ◽  
Mineral Balance

Abstract Background: We investigated whether changes in the natural isotopic composition of calcium in human urine track changes in net bone mineral balance, as predicted by a model of calcium isotopic behavior in vertebrates. If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. Methods: Calcium isotopic compositions are expressed as δ44Ca, or the difference in parts per thousand between the 44Ca/40Ca of a sample and the 44Ca/40Ca of a standard reference material. δ44Ca was measured in urine samples from 10 persons who participated in a study of the effectiveness of countermeasures to bone loss in spaceflight, in which 17 weeks of bed rest was used to induce bone loss. Study participants were assigned to 1 of 3 treatment groups: controls received no treatment, one treatment group received alendronate, and another group performed resistive exercise. Measurements were made on urine samples collected before, at 2 or 3 points during, and after bed rest. Results: Urine δ44Ca values during bed rest were lower in controls than in individuals treated with alendronate (P &lt;0.05, ANOVA) or exercise (P &lt;0.05), and lower than the control group baseline (P &lt;0.05, t-test). Results were consistent with the model and with biochemical and bone mineral density data. Conclusion: Results confirm the predicted relationship between bone mineral balance and calcium isotopes, suggesting that calcium isotopic analysis of urine might be refined into a clinical and research tool.

scholarly journals Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins

Bone ◽  
2007 ◽  
Vol 40 (2) ◽  
pp. 529-537 ◽  
Author(s):  
Sara R. Zwart ◽  
Alan R. Hargens ◽  
Stuart M.C. Lee ◽  
Brandon R. Macias ◽  
Donald E. Watenpaugh ◽  
...  
Keyword(s):  
Bone Loss ◽  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Identical Twins ◽  
Lower Body

Resistive vibration exercise retards bone loss in weight-bearing skeletons during 60 days bed rest

2011 ◽  
Vol 23 (8) ◽  
pp. 2169-2178 ◽  
Author(s):  
H. Wang ◽  
Y. Wan ◽  
K.-F. Tam ◽  
S. Ling ◽  
Y. Bai ◽  
...  
Keyword(s):  
Bone Loss ◽  
Weight Bearing ◽  
Bed Rest ◽  
Vibration Exercise

scholarly journals Bone loss patterns in cortical, subcortical, and trabecular compartments during simulated microgravity

2014 ◽  
Vol 117 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Tomas Cervinka ◽  
Harri Sievänen ◽  
Jari Hyttinen ◽  
Jörn Rittweger
Keyword(s):  
Bone Loss ◽  
Study Design ◽  
Simulated Microgravity ◽  
Loss Rate ◽  
Bed Rest ◽  
Bone Adaptation ◽  
Control Groups ◽  
The Mean ◽  
Skeletal Adaptation ◽  
Bone Loss Rate

Disuse studies provide a useful model for bone adaptation. A direct comparison of these studies is, however, complicated by the different settings used for bone analysis. Through pooling and reanalysis of bone data from previous disuse studies, we determined bone loss and recovery in cortical, subcortical, and trabecular compartments and evaluated whether the study design modulated skeletal adaptation. Peripheral quantitative tomographic (pQCT) images from control groups of four disuse studies with a duration of 24, 35, 56, and 90 days were reanalyzed using a robust threshold-free segmentation algorithm. The pQCT data were available from 27 young healthy men at baseline, and at specified intervals over disuse and reambulation phases. The mean maximum absolute bone loss (mean ± 95% CI) was 6.1 ± 4.5 mg/mm in cortical, 2.4 ± 1.6 mg/mm in subcortical, and 9.8 ± 9.1 mg/mm in trabecular compartments, after 90 days of bed rest. The percentage changes in all bone compartments were, however, similar. During the first few weeks after onset of reambulation, the bone loss rate was systematically greater in the cortical than in the trabecular compartment ( P < 0.002), and this was observed in all studies except for the longest study. We conclude that disuse-induced bone losses follow similar patterns irrespective of study design, and the largest mean absolute bone loss occurs in the cortical compartment, but apparently only during the first 60 days. With longer study duration, trabecular loss may become more prominent.

scholarly journals Effects of high-protein intake on bone turnover in long-term bed rest in women

2017 ◽  
Vol 42 (5) ◽  
pp. 537-546 ◽  
Author(s):  
Martina Heer ◽  
Natalie Baecker ◽  
Petra Frings-Meuthen ◽  
Sonja Graf ◽  
Sara R. Zwart ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Bone Turnover ◽  
Muscle Mass ◽  
Protein Intake ◽  
Bed Rest ◽  
High Protein ◽  
Mineral Density ◽  
High Protein Intake ◽  
Potassium Intake

Bed rest (BR) causes bone loss, even in otherwise healthy subjects. Several studies suggest that ambulatory subjects may benefit from high-protein intake to stimulate protein synthesis and to maintain muscle mass. However, increasing protein intake above the recommended daily intake without adequate calcium and potassium intake may increase bone resorption. We hypothesized that a regimen of high-protein intake (HiPROT), applied in an isocaloric manner during BR, with calcium and potassium intake meeting recommended values, would prevent any effect of BR on bone turnover. After a 20-day ambulatory adaptation to a controlled environment, 16 women participated in a 60-day, 6° head-down-tilt (HDT) BR and were assigned randomly to 1 of 2 groups. Control (CON) subjects (n = 8) received 1 g/(kg body mass·day)−1 dietary protein. HiPROT subjects (n = 8) received 1.45 g protein/(kg body mass·day)−1 plus an additional 0.72 g branched-chain amino acids per day during BR. All subjects received an individually tailored diet (before HDTBR: 1888 ± 98 kcal/day; during HDTBR: 1604 ± 125 kcal/day; after HDTBR: 1900 ± 262 kcal/day), with the CON group’s diet being higher in fat and carbohydrate intake. High-protein intake exacerbated the BR-induced increase in bone resorption marker C-telopeptide (>30%) (p < 0.001) by the end of BR. Bone formation markers were unaffected by BR and high-protein intake. We conclude that high-protein intake in BR might increase bone loss. Further long-duration studies are mandatory to show how the positive effect of protein on muscle mass can be maintained without the risk of reducing bone mineral density.

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