Expression of osteoblastic and osteoclastic genes during spontaneous regeneration and autotransplantation of goldfish scale: A new tool to study intramembranous bone regeneration

Bone ◽  
2012 ◽  
Vol 50 (6) ◽  
pp. 1240-1249 ◽  
Author(s):  
Thiparpa Aime Thamamongood ◽  
Ryo Furuya ◽  
Shunsuke Fukuba ◽  
Masahisa Nakamura ◽  
Nobuo Suzuki ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Intramembranous Bone ◽  
Spontaneous Regeneration

scholarly journals Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
S. Lee ◽  
L. H. Remark ◽  
A. M. Josephson ◽  
K. Leclerc ◽  
E. Muiños Lopez ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Notch Signaling ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Canonical Wnt Signaling ◽  
Osteoprogenitor Cells ◽  
Intramembranous Bone ◽  
Proliferation And Differentiation ◽  
Canonical Wnt ◽  
Wnt Signal

AbstractAdult bone regeneration is orchestrated by the precise actions of osteoprogenitor cells (OPCs). However, the mechanisms by which OPC proliferation and differentiation are linked and thereby regulated are yet to be defined. Here, we present evidence that during intramembranous bone formation OPC proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling. The temporospatial separation of Notch and Wnt signal activation during the early stages of bone regeneration suggests crosstalk between the two pathways. In vitro and in vivo manipulation of the two essential pathways demonstrate that Wnt activation leads to initiation of osteogenic differentiation and at the same time inhibits Notch signaling, which results in termination of the proliferative phase. Here, we establish canonical Wnt signaling as a key regulator that facilitates the crosstalk between OPC proliferation and differentiation during intramembranous, primary bone healing.

Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats

2009 ◽  
Vol 14 (4) ◽  
pp. 431-436 ◽  
Author(s):  
Simo S.A. Miettinen ◽  
Jarkko Jaatinen ◽  
Alpo Pelttari ◽  
Reijo Lappalainen ◽  
Jukka Mönkkönen ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Regeneration ◽  
Titanium Implant ◽  
Intramembranous Bone

Cambridge experience in spontaneous bone regeneration after traumatic segmental bone defect: a case series and review of literature

2020 ◽  
Vol 13 (4) ◽  
pp. e232482
Author(s):  
Ali Abdulkarim ◽  
Shu Yang Hu ◽  
Brendon R Walker ◽  
Matija Krkovic
Keyword(s):  
Bone Regeneration ◽  
Case Series ◽  
Patient Characteristics ◽  
High Energy ◽  
Long Bone ◽  
Review Of Literature ◽  
Segmental Bone Defect ◽  
Management Guidelines ◽  
Spontaneous Regeneration ◽  
Segmental Bone

High-energy traumatic long bone defects are some of the most challenging to reconstruct. Although cases of spontaneous bone regeneration in these defects have been reported, we are aware of no management guidelines or recommendations for when spontaneous bone regeneration should be considered a viable management option. We aim to identify how certain patient characteristics and surgical factors may help predict spontaneous bone regeneration. A total of 26 cases with traumatic segmental defects were treated at our institution, with eight cases (30.8%) undergoing spontaneous regeneration. We discuss four in detail. Six (75%) reported a degree of periosteal preservation, four (50%) were associated with traumatic brain injury and none were complicated by infection. The average time to spontaneous bone regeneration was 2.06 months. According to our cases, patients with favourable characteristics may benefit from delaying surgical treatment by 6 weeks to monitor for any signs of spontaneous bone formation.

Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation

2015 ◽  
Vol 33 (9) ◽  
pp. 1374-1381 ◽  
Author(s):  
Meghan M. Moran ◽  
Amarjit S. Virdi ◽  
Kotaro Sena ◽  
Steven R. Mazzone ◽  
Margaret A. McNulty ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Intramembranous Bone ◽  
Marrow Ablation

Patterns and Localization of Gene Expression During Intramembranous Bone Regeneration in the Rat Femoral Marrow Ablation Model

2005 ◽  
Vol 77 (4) ◽  
pp. 212-225 ◽  
Author(s):  
Shinji Kuroda ◽  
Amarjit S. Virdi ◽  
Yang Dai ◽  
Susan Shott ◽  
Dale R. Sumner
Keyword(s):  
Gene Expression ◽  
Bone Regeneration ◽  
Intramembranous Bone ◽  
Marrow Ablation ◽  
Ablation Model

scholarly journals Evaluation of Spontaneous Bone Regeneration after Enucleation of Large Cysts of the Jaws using Radiographic Computed Software

2016 ◽  
Vol 17 (6) ◽  
pp. 489-495 ◽  
Author(s):  
Shivaraj S Wagdargi ◽  
Kirthi Kumar Rai ◽  
KV Arunkumar ◽  
Basavraj Katkol ◽  
Gururaj Arakeri
Keyword(s):  
Bone Regeneration ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Graft Material ◽  
Foreign Substance ◽  
Jaw Cyst ◽  
Simple Enucleation ◽  
Spontaneous Regeneration ◽  
Regeneration Of Bone

ABSTRACT Introduction Spontaneous regeneration of bone is commonly seen in the small surgical defects caused by enucleation of cysts. However, in case of large surgical defects caused by the enucleation, spontaneous regeneration of bone is a rare phenomenon and it depends on factors, such as age of the patient, intact periosteum, and proper stabilization. Materials and methods The study included 16 patients, who reported to the department of oral and maxillofacial surgery with the complaint of pain and swelling in the jaws diagnosed as cyst. The sample included equal numbers of male and female subjects aged between 15 and 40 years. Panoramic radiographs were taken pre- and postoperatively on day 2 of the enucleation. The dimensions of the cyst were evaluated on the radiograph according to the proforma. Subsequent radiographs were taken at regular intervals of 1.5, 3, and 6 months using standard parameters and were analyzed using MCID™ analysis software of imaging research. Results Mean reduction was seen in up to 39 and 60% in the cystic cavity size and increase in the mean density up to 59 and 90.2% at 3 and 6 months intervals respectively. Conclusion Spontaneous bone regeneration was seen even after primary closure of the large cystic defect without the need for placement of foreign substances or grafts and it also eliminated the complications resulting from placement of foreign substance. Further studies are required in a larger sample with longer follow-up durations to confirm the outcome of the present work for the benefit of patients. Clinical significance The present study depicted that spontaneous bone regeneration can occur with accepted results after simple enucleation of jaw cyst without the aid of any graft material. Hence, simple enucleation may be considered as a first line of treatment modality for cystic lesion of the jaws. This simplifies the surgical procedure, decreases the economic and biologic costs, and reduces the risk of postoperative complications. Follow-up is necessary along with patient's compliance for the success of treatment. How to cite this article Wagdargi SS, Rai KK, Arunkumar KV, Katkol B, Arakeri G. Evaluation of Spontaneous Bone Regeneration after Enucleation of Large Cysts of the Jaws using Radiographic Computed Software. J Contemp Dent Pract 2016;17(6):489-495.

scholarly journals Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models

2016 ◽  
Vol 5 ◽  
Author(s):  
Meghan M Moran ◽  
Kotaro Sena ◽  
Margaret A McNulty ◽  
D R Sumner ◽  
Amarjit S Virdi
Keyword(s):  
Bone Regeneration ◽  
Rodent Models ◽  
Implant Placement ◽  
Intramembranous Bone ◽  
Marrow Ablation
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