scholarly journals How faithfully does intramembranous bone regeneration recapitulate embryonic skeletal development?

2020 ◽  
Author(s):  
Frank C. Ko ◽  
D. Rick Sumner
Keyword(s):  
Bone Regeneration ◽  
Skeletal Development ◽  
Intramembranous Bone

scholarly journals Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
S. Lee ◽  
L. H. Remark ◽  
A. M. Josephson ◽  
K. Leclerc ◽  
E. Muiños Lopez ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Notch Signaling ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Canonical Wnt Signaling ◽  
Osteoprogenitor Cells ◽  
Intramembranous Bone ◽  
Proliferation And Differentiation ◽  
Canonical Wnt ◽  
Wnt Signal

AbstractAdult bone regeneration is orchestrated by the precise actions of osteoprogenitor cells (OPCs). However, the mechanisms by which OPC proliferation and differentiation are linked and thereby regulated are yet to be defined. Here, we present evidence that during intramembranous bone formation OPC proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling. The temporospatial separation of Notch and Wnt signal activation during the early stages of bone regeneration suggests crosstalk between the two pathways. In vitro and in vivo manipulation of the two essential pathways demonstrate that Wnt activation leads to initiation of osteogenic differentiation and at the same time inhibits Notch signaling, which results in termination of the proliferative phase. Here, we establish canonical Wnt signaling as a key regulator that facilitates the crosstalk between OPC proliferation and differentiation during intramembranous, primary bone healing.

Role of FGFs/FGFRs in skeletal development and bone regeneration

2012 ◽  
Vol 227 (12) ◽  
pp. 3731-3743 ◽  
Author(s):  
Xiaolan Du ◽  
Yangli Xie ◽  
Cory J. Xian ◽  
Lin Chen
Keyword(s):  
Bone Regeneration ◽  
Skeletal Development

Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats

2009 ◽  
Vol 14 (4) ◽  
pp. 431-436 ◽  
Author(s):  
Simo S.A. Miettinen ◽  
Jarkko Jaatinen ◽  
Alpo Pelttari ◽  
Reijo Lappalainen ◽  
Jukka Mönkkönen ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Regeneration ◽  
Titanium Implant ◽  
Intramembranous Bone

Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation

2015 ◽  
Vol 33 (9) ◽  
pp. 1374-1381 ◽  
Author(s):  
Meghan M. Moran ◽  
Amarjit S. Virdi ◽  
Kotaro Sena ◽  
Steven R. Mazzone ◽  
Margaret A. McNulty ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Intramembranous Bone ◽  
Marrow Ablation

Patterns and Localization of Gene Expression During Intramembranous Bone Regeneration in the Rat Femoral Marrow Ablation Model

2005 ◽  
Vol 77 (4) ◽  
pp. 212-225 ◽  
Author(s):  
Shinji Kuroda ◽  
Amarjit S. Virdi ◽  
Yang Dai ◽  
Susan Shott ◽  
Dale R. Sumner
Keyword(s):  
Gene Expression ◽  
Bone Regeneration ◽  
Intramembranous Bone ◽  
Marrow Ablation ◽  
Ablation Model

scholarly journals VEGF stimulates intramembranous bone formation during craniofacial skeletal development

2016 ◽  
Vol 52-54 ◽  
pp. 127-140 ◽  
Author(s):  
Xuchen Duan ◽  
Seth R. Bradbury ◽  
Bjorn R. Olsen ◽  
Agnes D. Berendsen
Keyword(s):  
Bone Formation ◽  
Skeletal Development ◽  
Intramembranous Bone ◽  
Intramembranous Bone Formation

Expression of osteoblastic and osteoclastic genes during spontaneous regeneration and autotransplantation of goldfish scale: A new tool to study intramembranous bone regeneration

Bone ◽  
2012 ◽  
Vol 50 (6) ◽  
pp. 1240-1249 ◽  
Author(s):  
Thiparpa Aime Thamamongood ◽  
Ryo Furuya ◽  
Shunsuke Fukuba ◽  
Masahisa Nakamura ◽  
Nobuo Suzuki ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Intramembranous Bone ◽  
Spontaneous Regeneration

scholarly journals Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models

2016 ◽  
Vol 5 ◽  
Author(s):  
Meghan M Moran ◽  
Kotaro Sena ◽  
Margaret A McNulty ◽  
D R Sumner ◽  
Amarjit S Virdi
Keyword(s):  
Bone Regeneration ◽  
Rodent Models ◽  
Implant Placement ◽  
Intramembranous Bone ◽  
Marrow Ablation
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