Combined effects of cadmium exposure and estrogen depletion responsible for developing itai-itai disease in postmenopausal women

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S141-S142
Author(s):  
M.M. Kakei⁎ ◽  
T. Sakae ◽  
H. Mishima ◽  
M. Yoshikawa
Keyword(s):  
Postmenopausal Women ◽  
Cadmium Exposure ◽  
Combined Effects ◽  
Estrogen Depletion

scholarly journals Effect of Adherence to Physical Exercise on Cardiometabolic Profile in Postmenopausal Women

2021 ◽  
Vol 18 (2) ◽  
pp. 656
Author(s):  
Valentina Bucciarelli ◽  
Francesco Bianco ◽  
Francesco Mucedola ◽  
Andrea Di Blasio ◽  
Pascal Izzicupo ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Diastolic Function ◽  
Postmenopausal Women ◽  
Serum Glucose ◽  
Moderate Intensity ◽  
Adherence Rate ◽  
Before And After ◽  
Estrogen Depletion ◽  
The Impact ◽  
Cardiometabolic Profile

Background: Menopause is associated with negative cardiovascular adaptations related to estrogen depletion, which could be counteracted by physical exercise (PhE). However, the impact of total adherence-rate (TA) to PhE and sedentary time (SedT) on cardiometabolic profile in this population has not been elucidated. Methods: For 13-weeks, 43 women (57.1 ± 4.7 years) participated in a 4-days-a-week moderate-intensity walking training. They underwent laboratory, anthropometric and echocardiographic assessment, before and after training (T0–T1). Spontaneous physical activity (PhA) was assessed with a portable multisensory device. The sample was divided according to TA to PhE program: <70% (n = 17) and ≥70% (n = 26). Results: TA ≥ 70% group experienced a significant T1 improvement of relative wall thickness (RWT), diastolic function, VO2max, cortisol, cortisol/dehydroandrostenedione-sulphate ratio and serum glucose. After adjusting for SedT and 10-min bouts of spontaneous moderate-to-vigorous PhA, TA ≥ 70% showed the most significant absolute change of RWT and diastolic function, body mass index, weight and cortisol. TA ≥ 70% was major predictor of RWT and cortisol improvement. Conclusions: In a group of untrained, postmenopausal women, a high TA to a 13-weeks aerobic PhE program confers a better improvement in cardiometabolic profile, regardless of SedT and PhA levels.

scholarly journals Combined effects of aerobic exercise and l -arginine ingestion on blood pressure in normotensive postmenopausal women: A crossover study

Life Sciences ◽  
2016 ◽  
Vol 151 ◽  
pp. 323-329 ◽  
Author(s):  
Guilherme M. Puga ◽  
Iane de P. Novais ◽  
Christos S. Katsanos ◽  
Angelina Zanesco
Keyword(s):  
Blood Pressure ◽  
Aerobic Exercise ◽  
Crossover Study ◽  
Postmenopausal Women ◽  
Combined Effects

scholarly journals Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women

Obesity ◽  
2013 ◽  
Vol 21 (12) ◽  
pp. E549-E554 ◽  
Author(s):  
Caitlin Mason ◽  
Rosa-Ana Risques ◽  
Liren Xiao ◽  
Catherine R. Duggan ◽  
Ikuyo Imayama ◽  
...  
Keyword(s):  
Weight Loss ◽  
Postmenopausal Women ◽  
Telomere Length ◽  
Combined Effects ◽  
Leukocyte Telomere Length ◽  
Dietary Weight Loss

scholarly journals Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Lulu Wang ◽  
Zhenxing Mao ◽  
Xiaotian Liu ◽  
Dandan Wei ◽  
Pengling Liu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Trial Registration ◽  
Cytokine Signaling ◽  
Combined Effects ◽  
Clinical Trial Registration ◽  
Serum Progesterone ◽  
Control Study

Abstract Background This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling (SOCS)-3 DNA methylation on type 2 diabetes mellitus (T2DM) among men and postmenopausal women in rural China. Methods A case–control study with 914 participants (329 T2DM, 585 controls) was conducted. Serum progesterone was detected with liquid chromatography-tandem mass spectrometry. DNA methylation of SOCS3 was determined by MethylTarget™. Linear regression was applied to evaluate the associations of progesterone and SOCS3 methylation with marks of glucose metabolism. Logistic regression was employed to investigate the independent and combined effects of progesterone and SOCS3 methylation with T2DM in men and postmenopausal women. Results After multiple adjustment, progesterone was positively associated with T2DM in both men (odds ratio (OR) (95% confidence interval (CI)): 2.77 (1.79, 4.29)) and postmenopausal women (OR (95% CI): 1.85 (1.26, 2.72)). Methylation level of Chr17:76,356,190 or Chr17:76,356,199 (SOCS3) was negatively associated with T2DM in both men (OR (95% CI): 0.58 (0.39, 0.86) or 0.27 (0.14, 0.51)) and postmenopausal women (OR (95% CI): 0.43 (0.29, 0.65) or 0.53 (0.28, 0.99)). Subjects with high progesterone and low Chr17:76,356,190 or Chr17:76,356,199 methylation were more susceptible to have a higher prevalence of T2DM (men: OR (95% CI): 5.20 (2.49, 10.85) or 5.62 (2.74, 11.54); postmenopausal women: OR (95% CI): 3.66 (1.85, 7.26) or 3.27 (1.66, 6.45)). Conclusions The independent and combined effects of progesterone and SOCS3 methylation on T2DM were found among men and postmenopausal women, suggesting that ensuring low levels of progesterone and high methylation of SOCS3 could reduce the prevalence of T2DM. Trial registration The Chinese Clinical Trial registration: The Henan Rural Cohort Study, ChiCTR-OOC-15006699. Registered 06 July 2015, http://www.chictr.org.cn/showproj.aspx?proj=11375

Independent and Combined Effects of Niacin and Exercise on Blood Lipid and Lipoprotein Profiles in Postmenopausal Women

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S57
Author(s):  
Yunsuk Koh ◽  
Heidi Bidstrup ◽  
James Rowe ◽  
Kyle D. Biggerstaff ◽  
David L. Nichols ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Blood Lipid ◽  
Combined Effects ◽  
Lipoprotein Profiles

scholarly journals Inflammatory Potential of Diet Is Associated with Biomarkers Levels of Inflammation and Cognitive Function among Postmenopausal Women

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2323
Author(s):  
Aleksandra Skoczek-Rubińska ◽  
Agata Muzsik-Kazimierska ◽  
Agata Chmurzynska ◽  
Małgorzata Jamka ◽  
Jarosław Walkowiak ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Postmenopausal Women ◽  
Necrosis Factor Alpha ◽  
Physically Active ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Anti Inflammatory ◽  
Estrogen Depletion

In postmenopausal women (PW), estrogen depletion may predispose to cognitive decline through an increased risk of chronic inflammation. Unhealthy diets also appear to have an impact on the cognitive health of these women. The aim of this study was to investigate the association between inflammatory potential of the diet, levels of inflammatory biomarkers, and cognitive function in PW. In a population of 222 PW, energy intake-adjusted Dietary Inflammatory Index (E-DII) was used to assess the dietary inflammatory potential. Cognitive function was estimated using the Polish version of Mini-Mental State Examination (MMSE), corrected by age and educational level. Selected biochemical inflammatory markers (C-reactive protein, CRP; interleukin-6, IL-6; and tumor necrosis factor alpha, TNF-α) were measured by ELISA tests. PW with an anti-inflammatory diet (first tercile) had significantly higher MMSE, while BMI, percentage fat mass and TNFα concentration were significantly lower compared to those with the most proinflammatory diets (third tercile). Women with cognitive impairment had significantly higher IL-6 concentrations (4.1 (0.8) pg/mL vs. 2.5 (0.2) pg/mL, p = 0.004), and were less educated (12.7 (0.7) years vs. 14.1 (0.2) years, p = 0.03) and less physically active compared to cognitively normal women. PW with the most proinflammatory diets had increased odds of cognitive impairment compared to those with the most anti-inflammatory diets, even after adjustment (OR = 11.10, 95% confidence level; 95%CI: 2.22; 55.56; p = 0.002). Each one-point increase in E-DII (as a continuous value) was also associated with 1.55-times greater odds of cognitive impairment (95%Cl: 1.19; 2.02 p = 0.003) in this population. Dietary inflammation may increase the risk of cognitive impairment in PW, but future studies should include a more sensitive battery of tests to assess cognitive function in this population. Implementation of an anti-inflammatory dietary pattern in PW may help prevent cognitive decline.

scholarly journals Combined Effects of Metabolic Abnormalities and Obesity on Cardiovascular Diseases among Korean Postmenopausal Women

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1064
Author(s):  
Jin Suk Ra
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Cardiovascular Diseases ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Metabolic Abnormality ◽  
Combined Effects ◽  
Metabolic Abnormalities ◽  
Korean Women ◽  
Early Management

Combined effects of metabolic abnormalities, including metabolic syndrome and obesity, should be identified to screen postmenopausal women at risk of developing cardiovascular diseases. The purpose of this study was to identify the combined effects of metabolic abnormalities and obesity on cardiovascular diseases among postmenopausal Korean women (aged 40–83 years). Data of 5959 postmenopausal women from the Korean National Health and Nutrition Examination Survey (2015–2018) were secondarily analyzed. Using complex simple analysis procedures, logistic regression analysis was performed to identify the combined effect of metabolic abnormalities and obesity on cardiovascular diseases among postmenopausal Korean women. In combination, metabolic syndrome (more than three metabolic abnormalities) and obesity (overweight [≥23 kg/m2 and <25 kg/m2 in body mass index] and obese [>25 kg/m2 in body mass index]) increased the likelihood of developing cardiovascular diseases but combining more than one metabolic abnormality and obesity did not. Combining metabolic syndrome and non-obesity (underweight and normal weight) increased the likelihood of the prevalence of cardiovascular diseases but combining more than one metabolic abnormality and non-obesity did not. Increased cardiovascular diseases in postmenopausal women may be more commonly associated with metabolic syndrome having multiple metabolic abnormalities, but not obesity. Thus, instead of simple weight control, early management of metabolic syndrome is recommended to prevent cardiovascular disease among postmenopausal Korean women.

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