Systemic treatment with strontium ranelate markedly improves the healing of critical bone defect

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S163-S164
Author(s):  
G. Zacchetti ◽  
R. Rizzoli ◽  
P. Ammann
Keyword(s):  
Bone Defect ◽  
Strontium Ranelate ◽  
Systemic Treatment

Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats

2009 ◽  
Vol 21 (11) ◽  
pp. 1889-1897 ◽  
Author(s):  
Y. F. Li ◽  
E. Luo ◽  
G. Feng ◽  
S. S. Zhu ◽  
J. H. Li ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Strontium Ranelate ◽  
Tibial Fracture ◽  
Systemic Treatment ◽  
Ovariectomized Rats

scholarly journals Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats

2016 ◽  
Vol 27 (5) ◽  
pp. 502-507 ◽  
Author(s):  
Jucely Aparecida da Rosa ◽  
◽  
Kumiko Koibuchi Sakane ◽  
Karina Cecília Panelli Santos ◽  
Vivian Bradaschia Corrêa ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Defect ◽  
Strontium Ranelate ◽  
Bone Defects ◽  
Female Rats ◽  
Trabecular Thickness ◽  
Computed Microtomography ◽  
Group A ◽  
Molecular Components ◽  
Made In

Abstract This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was performed four weeks after the bone defect surgery. Repair in bone defect was assessed by computed microtomography (μCT) and chemical composition of cortical bone was analyzed by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray spectroscopy (EDS). The trabecular thickness (Tb.Th) of the newly formed bone in the OVX+SR group was significantly higher than that for the OVX group. The collagen maturity in the OVX+SR group was smaller than in the other two groups. In this group, a significant increase in the amount of strontium (Sr) and a decrease in the amount of calcium (Ca) embedded to bone tissue were also observed. Systemic treatment with SR improved microarchitecture of the newly formed bone inside the defect, but decreased cross-linking of mature collagen in cortical bone.

Systemic Treatment with Strontium Ranelate Does Not Influence the Healing of Femoral Mid-shaft Defects in Rats

2015 ◽  
Vol 98 (2) ◽  
pp. 206-214 ◽  
Author(s):  
Jens Bay Vegger ◽  
Annemarie Brüel ◽  
Thomas Givskov Sørensen ◽  
Jesper Skovhus Thomsen
Keyword(s):  
Strontium Ranelate ◽  
Systemic Treatment

scholarly journals Strontium ranelate stimulates trabecular bone formation in a rat tibial bone defect healing process

2017 ◽  
Vol 28 (12) ◽  
pp. 3475-3487 ◽  
Author(s):  
C. Lavet ◽  
G. Mabilleau ◽  
D. Chappard ◽  
R. Rizzoli ◽  
P. Ammann
Keyword(s):  
Bone Formation ◽  
Trabecular Bone ◽  
Bone Defect ◽  
Strontium Ranelate ◽  
Healing Process ◽  
Defect Healing ◽  
Tibial Bone ◽  
Bone Defect Healing

scholarly journals Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Giovanna Zacchetti ◽  
Romain Dayer ◽  
René Rizzoli ◽  
Patrick Ammann
Keyword(s):  
Trabecular Bone ◽  
Cortical Bone ◽  
Bone Defect ◽  
Strontium Ranelate ◽  
Bone Microarchitecture ◽  
Female Rats ◽  
Micro Computed Tomography ◽  
Ct Analysis ◽  
Defect Filling

Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects of 2.5 mm in diameter were created in 6-month-old female rats orally fed SrRan (625 mg/kg/d; 5/7 days) or vehicle for 4, 8, or 12 weeks (10 rats per group per time point) from the time of surgery. Tibias were removed. Micro-architecture was determined by micro-computed tomography (µCT) and material level properties by nanoindentation analysis.µCT analysis showed that SrRan administration significantly improved microarchitecture of trabecular bone growing into the defect after 8 and 12 weeks of treatment compared to vehicle. SrRan treatment also accelerated the growth of cortical bone over the defect, but with different kinetics compared to trabecular bone, as the effects were already significant after 4 weeks. Nanoindentation analysis demonstrated that SrRan treatment significantly increased material level properties of both trabecular bone and cortical bone filling the defect compared to vehicle. SrRan accelerates the filling of bone defect by improving cortical and trabecular bone microarchitecture both quantitatively and qualitatively.

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