Systemic treatment with strontium ranelate accelerates the filling of a critical size bone defect and improves the intrinsic quality of the healing bone

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S57
Author(s):  
G. Zacchetti⁎ ◽  
R. Rizzoli ◽  
P. Ammann
Keyword(s):  
Bone Defect ◽  
Strontium Ranelate ◽  
Systemic Treatment ◽  
Critical Size ◽  
Intrinsic Quality ◽  
Healing Bone

Systemic treatment with strontium ranelate markedly improves the healing of critical bone defect

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S163-S164
Author(s):  
G. Zacchetti ◽  
R. Rizzoli ◽  
P. Ammann
Keyword(s):  
Bone Defect ◽  
Strontium Ranelate ◽  
Systemic Treatment

Systematic literature review of clinical outcomes in adults with metastatic or advanced synovial sarcoma

2020 ◽  
Vol 16 (35) ◽  
pp. 2997-3013
Author(s):  
Kentaro Kogushi ◽  
Michael LoPresti ◽  
Shunya Ikeda
Keyword(s):  
Synovial Sarcoma ◽  
High Frequency ◽  
Clinical Evidence ◽  
Systemic Treatment ◽  
Progression Free Survival ◽  
Treatment Modalities ◽  
Free Survival ◽  
New Treatment ◽  
Poor Outcomes

Background: Synovial sarcoma (SS) is a rare, aggressive soft tissue sarcoma with a poor prognosis after metastasis. The objective of this study was to conduct a systematic review of the clinical evidence for therapeutic options for adults with metastatic or advanced SS. Materials & methods: Relevant databases were searched with predefined keywords. Results: Thirty-nine publications reported clinical data for systemic treatment and other interventions. Data on survival outcomes varied but were generally poor (progression-free survival: 1.0–7.7 months; overall survival: 6.7–29.2 months) for adults with metastatic and advanced SS. A high frequency of neutropenia with systemic treatment and low quality of life post-progression were reported. Conclusion: Reported evidence suggests poor outcomes in adults with metastatic and advanced SS and the need for the development of new treatment modalities.

scholarly journals Obvious Reduction of the Tumor Size in Dedifferentiated Liposarcoma in a Lung Metastasis Patient Receiving Individualized Treatment

2021 ◽  
pp. 1080-1084
Author(s):  
Xin-Li Wang ◽  
Jia-Yao Gong ◽  
Yan Xue
Keyword(s):  
Quality Of Life ◽  
Therapeutic Effect ◽  
Tumor Size ◽  
Systemic Treatment ◽  
Treatment Method ◽  
Palliative Surgery ◽  
Dedifferentiated Liposarcoma ◽  
Comprehensive Treatment ◽  
Back Surgery

Abdominal metastasis is relatively rare in dedifferentiated liposarcoma of the shoulder and back. Surgery is the best treatment option, whether it is radical or palliative surgery. Chemotherapy is the standard systemic treatment for advanced unresectable/metastatic patients, but the therapeutic effect is limited. Here, we treat advanced abdominal dedifferentiated liposarcoma through a comprehensive treatment method of targeting, surgery, and chemotherapy, which improves the quality of life of the patient, and shrinks the tumor significantly.

scholarly journals Understanding Completeness and Diversity Patterns of OSM-Based Land-Use and Land-Cover Dataset in China

2020 ◽  
Vol 9 (9) ◽  
pp. 531
Author(s):  
ShuZhu Wang ◽  
Qi Zhou ◽  
YuanJian Tian
Keyword(s):  
Land Use ◽  
Land Cover ◽  
Quality Assessment ◽  
Socioeconomic Factors ◽  
Reference Dataset ◽  
Diversity Pattern ◽  
Diversity Patterns ◽  
Intrinsic Quality ◽  
Accuracy Measures

OpenStreetMap (OSM) data are considered essential for land-use and land-cover (LULC) mapping despite their lack of quality. Most relevant studies have employed an LULC reference dataset for quality assessment, but such a reference dataset is not freely available for most countries and regions. Thus, this study conducts an intrinsic quality assessment of the OSM-based LULC dataset (i.e., without using a reference LULC dataset) by examining the patterns of both its completeness and diversity. With China chosen as the study area, an OSM-based LULC dataset of the country was first generated and validated by using various accuracy measures. Both its completeness and diversity patterns were then mapped and analyzed in terms of each prefecture-level division of the country. The results showed the following: (1) While the overall accuracy was as high as 82.2%, most complete regions of China were not mapped well owing to a lack of diverse LULC classes. (2) In terms of socioeconomic factors and the number of contributors, higher correlations were noted for diversity patterns than completeness patterns; thus, the diversity pattern is a better reflection of socioeconomic factors and the spatial patterns of contributors. (3) Both the completeness and the diversity patterns can be combined to better understand an OSM-based LULC dataset. These results indicate that it is useful to consider diversity as a supplement for intrinsically assessing the quality of an OSM-based LULC dataset. This analytical method can also be applied to other countries and regions.

scholarly journals Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 180 ◽  
Author(s):  
Rodolfo Mauceri ◽  
Denise Murgia ◽  
Orazio Cicero ◽  
Luigi Paternò ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Healing ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Critical Size ◽  
Large Bone ◽  
Alveolar Bone Defect ◽  
Positive Results ◽  
Autologous Platelet

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

scholarly journals Surgical-prosthetic treatment of large mandibular cysts

2003 ◽  
Vol 60 (3) ◽  
pp. 365-368
Author(s):  
Ljubisa Dzambas ◽  
Asen Dzolev
Keyword(s):  
Quality Of Life ◽  
Soft Tissue ◽  
Bone Defect ◽  
Tissue Regeneration ◽  
Disease Patient ◽  
Daily Activities ◽  
Bone Tissue Regeneration ◽  
Tissue Loss ◽  
Mandibular Bone

This paper presents a combined surgical-prosthetic procedure of reconstructing mandibular bone defect in a 53 year old patient, following enucleation of a mandibular cyst (Cystectomy Partsch II). After a thorough diagnostic evaluation, a surgical procedure was planned with the particular attention to the nature of the disease, patient?s condition, size and extension of the cyst, tissue loss, and the possibilities of prosthetic management of a mandibular bone defect with partial postresection dental prosthesis. It is of great importance to point to the significance of teamwork of a maxillofacial surgeon and a specialist in prosthodontics. This kind of cooperation provided very effective and less risky soft tissue, as well as bone tissue regeneration (osteogenesis). The patient?s recovery was fast, and he could return to his daily activities and work without significant changes regarding quality of life after surgery and prosthetic treatment.

Guidelines of the Association of Polish Surgeons and the Polish Society of Surgical Oncology on the accreditation of healthcare centers providing cytoreductive surgery and HIPEC for primary and secondary peritoneal cancers

2020 ◽  
Vol 92 (4) ◽  
pp. 47-53
Author(s):  
Tomasz Jastrzębski ◽  
Piotr Richter ◽  
Wojciech Zegarski ◽  
Adam Dziki ◽  
Grzegorz Wallner ◽  
...  
Keyword(s):  
Cytoreductive Surgery ◽  
Systemic Treatment ◽  
Survival Rates ◽  
Surgical Oncology ◽  
Surgical Team ◽  
Surgical Interventions ◽  
Peritoneal Cancer ◽  
Polish Society ◽  
Patient Groups

Surgical interventions in patients with peritoneal metastases combined with hyperthermic intraperitoneal chemotherapy (HIPEC) and systemic treatment are becoming more common and, when applied to selected patient groups, they reach 5-year survival rates of 32–52%. Good clinical outcomes require experienced and well-equipped healthcare centers, experienced surgical team and adequate patient qualification process. As a result of the discussion on the need for evaluation of quality of care and treatment outcomes and at the request of the Peritoneal Cancer Section of the Polish Society of Surgical Oncology, accreditation standards have been developed and the Accreditation Committee has been established for healthcare centers providing cytoreductive surgery and HIPEC for the management of primary and secondary peritoneal cancers.

Sign in / Sign up

Export Citation Format

Share Document