Characterization of monocyte differentiation-inducing (MDI) factors derived from human fetal membrane chorion cells undergoing apoptosis after influenza virus infection

2006 ◽  
Vol 38 (11) ◽  
pp. 1926-1938 ◽  
Author(s):  
Noboru Uchide ◽  
Chiho Tadera ◽  
Hiroko Sarai ◽  
Kunio Ohyama ◽  
Toshio Bessho ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Fetal Membrane ◽  
Monocyte Differentiation

scholarly journals Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus Infection

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e57894 ◽  
Author(s):  
Olivier Leymarie ◽  
Grégory Jouvion ◽  
Pierre-Louis Hervé ◽  
Christophe Chevalier ◽  
Valérie Lorin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Kinetic Characterization ◽  
H5n1 Influenza Virus ◽  
Highly Pathogenic ◽  
H5n1 Influenza ◽  
Avian H5n1 Influenza Virus

scholarly journals Characterization of a new H-2Dk-restricted epitope prominent in primary influenza A virus infection

2001 ◽  
Vol 82 (7) ◽  
pp. 1749-1755 ◽  
Author(s):  
Sophie Tourdot ◽  
Shan Herath ◽  
Keith G. Gould
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Dominance Hierarchy ◽  
Influenza Virus Infection ◽  
Amino Acid Residues ◽  
Influenza A Virus Infection ◽  
Restricted Epitope

Influenza A virus infection of mice has been used extensively as a model to investigate the mechanisms of antigen presentation to cytotoxic T lymphocytes (CTL) and the phenomenon of immunodominance in antiviral CTL responses. The different virus-encoded epitopes that are recognized in H-2b and H-2d mice have been characterized and their relative immunodominance has been well-studied. In H-2k mice, four different Kk-restricted influenza virus epitopes have been described, but the dominance hierarchy of these epitopes is unknown and there is also an uncharacterized Dk-restricted response against the virus. In this study, a Dk-restricted epitope derived from the influenza virus A/PR/8/34 polymerase protein PB1, corresponding to amino acid residues 349–357 (ARLGKGYMF), was identified. This peptide is the major epitope within the PB1 polymerase and is at least as dominant as any of the four Kk-restricted epitopes that are recognized in CBA mice following primary influenza virus infection. The PB1 epitope is only the fourth Dk-presented peptide to be reported and the sequence of this epitope confirms a Dk-restricted peptide motif, consisting of arginine at position two, arginine or lysine at position five and a hydrophobic residue at the carboxy terminus.

Characterization of porcine P58IPK gene and its up-regulation after H1N1 or H3N2 influenza virus infection

2013 ◽  
Vol 58 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Pengfei Jiang ◽  
Junge Wen ◽  
Hao Song ◽  
Xinyu Chen ◽  
Yan Sun ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
H3n2 Influenza ◽  
H3n2 Influenza Virus

scholarly journals Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-32 ◽  
Author(s):  
Noboru Uchide ◽  
Kunio Ohyama ◽  
Toshio Bessho ◽  
Makoto Takeichi ◽  
Hiroo Toyoda
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Proinflammatory Cytokines ◽  
Pregnancy Outcomes ◽  
Influenza Virus Infection ◽  
Adverse Pregnancy Outcomes ◽  
Fetal Membrane ◽  
Premature Delivery ◽  
Fetal Membranes ◽  
Adverse Pregnancy

Pregnant women are at an increased risk of influenza-associated adverse outcomes, such as premature delivery, based on data from the latest pandemic with a novel influenza A (H1N1) virus in 2009-2010. It has been suggested that the transplacental transmission of influenza viruses is rarely detected in humans. A series of our study has demonstrated that influenza virus infection induced apoptosis in primary cultured human fetal membrane chorion cells, from which a factor with monocyte differentiation-inducing (MDI) activity was secreted. Proinflammatory cytokines, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-β, were identified as a member of the MDI factor. Influenza virus infection induced the mRNA expression of not only the proinflammatory cytokines but also chemoattractive cytokines, such as monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1β, IL-8, growth-regulated oncogene (GRO)-α, GRO-β, epithelial cell-derived neutrophil-activating protein (ENA)-78, and interferon inducible protein (IP)-10 in cultured chorion cells. These cytokines are postulated to associate with human parturition. This paper, therefore, reviews (1) lessons from pandemic H1N1 2009 in pregnancy, (2) production of proinflammatory and chemoattractive cytokines by human fetal membranes and their functions in gestational tissues, and (3) possible roles of cytokines produced by human fetal membranes in the pathology of adverse pregnancy outcomes associated with influenza virus infection.

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