scholarly journals Current Status of Monocyte Differentiation-Inducing (MDI) Factors Derived from Human Fetal Membrane Chorion Cells Undergoing Apoptosis after Influenza Virus Infection

2007 ◽  
Vol 1 ◽  
pp. GRSB.S374 ◽  
Author(s):  
Noboru Uchide ◽  
Hiroo Toyoda
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Current Status ◽  
Fetal Membrane ◽  
Monocyte Differentiation

Current Status on Development of Nucleic Acid-Based Antiviral Drugs Against Influenza Virus Infection

2007 ◽  
pp. 126-147
Author(s):  
Jonathan P. Wong ◽  
Mary E. Christopher ◽  
Murray Cairns ◽  
L.-Q. Sun ◽  
Roderic M. K. Dale ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Nucleic Acid ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Antiviral Drugs ◽  
Current Status

scholarly journals Possible Roles of Proinflammatory and Chemoattractive Cytokines Produced by Human Fetal Membrane Cells in the Pathology of Adverse Pregnancy Outcomes Associated with Influenza Virus Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-32 ◽  
Author(s):  
Noboru Uchide ◽  
Kunio Ohyama ◽  
Toshio Bessho ◽  
Makoto Takeichi ◽  
Hiroo Toyoda
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Proinflammatory Cytokines ◽  
Pregnancy Outcomes ◽  
Influenza Virus Infection ◽  
Adverse Pregnancy Outcomes ◽  
Fetal Membrane ◽  
Premature Delivery ◽  
Fetal Membranes ◽  
Adverse Pregnancy

Pregnant women are at an increased risk of influenza-associated adverse outcomes, such as premature delivery, based on data from the latest pandemic with a novel influenza A (H1N1) virus in 2009-2010. It has been suggested that the transplacental transmission of influenza viruses is rarely detected in humans. A series of our study has demonstrated that influenza virus infection induced apoptosis in primary cultured human fetal membrane chorion cells, from which a factor with monocyte differentiation-inducing (MDI) activity was secreted. Proinflammatory cytokines, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-β, were identified as a member of the MDI factor. Influenza virus infection induced the mRNA expression of not only the proinflammatory cytokines but also chemoattractive cytokines, such as monocyte chemoattractant protein (MCP)-1, regulated on activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1β, IL-8, growth-regulated oncogene (GRO)-α, GRO-β, epithelial cell-derived neutrophil-activating protein (ENA)-78, and interferon inducible protein (IP)-10 in cultured chorion cells. These cytokines are postulated to associate with human parturition. This paper, therefore, reviews (1) lessons from pandemic H1N1 2009 in pregnancy, (2) production of proinflammatory and chemoattractive cytokines by human fetal membranes and their functions in gestational tissues, and (3) possible roles of cytokines produced by human fetal membranes in the pathology of adverse pregnancy outcomes associated with influenza virus infection.

scholarly journals Regulation of Matrix Metalloproteinases-2 and -9 Gene Expression in Cultured Human Fetal Membrane Cells by Influenza Virus Infection

2016 ◽  
Vol 39 (12) ◽  
pp. 1912-1921 ◽  
Author(s):  
Noboru Uchide ◽  
Kyoko Obatake ◽  
Rie Yamada ◽  
Hidetaka Sadanari ◽  
Keiko Matsubara ◽  
...  
Keyword(s):  
Gene Expression ◽  
Influenza Virus ◽  
Matrix Metalloproteinases ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Fetal Membrane
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