Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure–activity relationship

2006 ◽  
Vol 72 (8) ◽  
pp. 1010-1021 ◽  
Author(s):  
Mònica Comalada ◽  
Isabel Ballester ◽  
Elvira Bailón ◽  
Saleta Sierra ◽  
Jordi Xaus ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Inflammatory Markers ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Mouse Macrophages ◽  
Primary Bone ◽  
Primary Bone Marrow

Bioactivities of Natural Catalpol Derivatives

2019 ◽  
Vol 26 (33) ◽  
pp. 6149-6173 ◽  
Author(s):  
Liu-Qiang Zhang ◽  
Kai-Xian Chen ◽  
Yi-Ming Li
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Inhibitory Potency ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Extensive Coverage ◽  
Relationship Of

Catalpol, a famous molecule of iridoids, possesses extensive pharmacological activities. Our studies found that compounds with low-polarity substituents at the 6-O position of catalpol exhibited higher NF-κB inhibitory potency than catalpol. However, catalpol derivatives are not much focused. Here this review provides extensive coverage of naturally occurring catalpol derivatives discovered from 1888 until 2018. It covers their distribution, chemotaxonomic significance, chemical structures, and bioactivities from more than 200 peer-reviewed articles, and highlights the structure-activity relationship of catalpol derivatives.

scholarly journals Structure–activity relationship and mechanism of four monostilbenes with respect to ferroptosis inhibition

RSC Advances ◽  
2020 ◽  
Vol 10 (52) ◽  
pp. 31171-31179
Author(s):  
Xiaojian Ouyang ◽  
Xican Li ◽  
Jie Liu ◽  
Yangping Liu ◽  
Yulu Xie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Erastin-treated bone marrow-derived mesenchymal stem cells (bmMSCs) were prepared and used to compare the ferroptosis inhibitory bioactivities of four monostilbenes, including rhapontigenin (1a), isorhapontigenin (1b), piceatannol-3′-O-glucoside (1c), and rhapontin (1d).

(7S)-Kaitocephalin as a potent NMDA receptor selective ligand

2016 ◽  
Vol 14 (4) ◽  
pp. 1206-1210 ◽  
Author(s):  
Yoko Yasuno ◽  
Makoto Hamada ◽  
Masanori Kawasaki ◽  
Keiko Shimamoto ◽  
Yasushi Shigeri ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligand ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Selective Ligand ◽  
Sar Study

A structure–activity relationship (SAR) study of kaitocephalin, known to be a potent naturally occurring NMDA receptor ligand, was performed.

Sign in / Sign up

Export Citation Format

Share Document