(7S)-Kaitocephalin as a potent NMDA receptor selective ligand

2016 ◽  
Vol 14 (4) ◽  
pp. 1206-1210 ◽  
Author(s):  
Yoko Yasuno ◽  
Makoto Hamada ◽  
Masanori Kawasaki ◽  
Keiko Shimamoto ◽  
Yasushi Shigeri ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligand ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Selective Ligand ◽  
Sar Study

A structure–activity relationship (SAR) study of kaitocephalin, known to be a potent naturally occurring NMDA receptor ligand, was performed.

Bioactivities of Natural Catalpol Derivatives

2019 ◽  
Vol 26 (33) ◽  
pp. 6149-6173 ◽  
Author(s):  
Liu-Qiang Zhang ◽  
Kai-Xian Chen ◽  
Yi-Ming Li
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Inhibitory Potency ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Extensive Coverage ◽  
Relationship Of

Catalpol, a famous molecule of iridoids, possesses extensive pharmacological activities. Our studies found that compounds with low-polarity substituents at the 6-O position of catalpol exhibited higher NF-κB inhibitory potency than catalpol. However, catalpol derivatives are not much focused. Here this review provides extensive coverage of naturally occurring catalpol derivatives discovered from 1888 until 2018. It covers their distribution, chemotaxonomic significance, chemical structures, and bioactivities from more than 200 peer-reviewed articles, and highlights the structure-activity relationship of catalpol derivatives.

scholarly journals PRELIMINARY STRUCTURE–ACTIVITY RELATIONSHIP STUDY OF HEPTAMETHINE INDOCYANINE DYES FOR TUMOR-TARGETED IMAGING

2013 ◽  
Vol 06 (01) ◽  
pp. 1350003 ◽  
Author(s):  
QINYUAN GUO ◽  
SHENGLIN LUO ◽  
QINGRONG QI ◽  
CHUNMENG SHI
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Targeted Imaging ◽  
Structure Activity ◽  
Relationship Study ◽  
Tumor Accumulation ◽  
Sar Study

Our research has identified a couple of near-infrared (NIR) heptamethine indocyanine dyes exhibiting preferential tumor accumulation property for in vivo imaging. On the basis of our foregoing work, we describe here a preliminary structure–activity relationship (SAR) study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging.

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