Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1

2006 ◽  
Vol 72 (4) ◽  
pp. 405-414 ◽  
Author(s):  
Giovanna Petrangolini ◽  
Giuditta Cuccuru ◽  
Cinzia Lanzi ◽  
Monica Tortoreto ◽  
Sara Belluco ◽  
...  
Keyword(s):  
Cell Death ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Medullary Thyroid ◽  
Angiogenesis Inhibition

scholarly journals Survivin in relation to Bcl-2, Bax and in situ apoptotic cell death in anaplastic thyroid carcinoma

2011 ◽  
Vol 63 (4) ◽  
pp. 955-963
Author(s):  
Sonja Selemetjev ◽  
Dubravka Cvejic ◽  
Svetlana Savin ◽  
I. Paunovic ◽  
S. Tatic
Keyword(s):  
Cell Death ◽  
Thyroid Carcinoma ◽  
Apoptotic Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Apoptotic Cell Death ◽  
Staining Score ◽  
Human Malignancy ◽  
Apoptotic Pathways ◽  
Individual Scores

Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive human malignancy. It is known that disturbances in apoptotic pathways have a great impact on tumor progression and aggressiveness. In this study the apoptosisrelated molecules Bcl-2 (antiapoptotic), Bax (proapoptotic) and survivin (an inhibitor of apoptosis) were analyzed immunohistochemically in thirty archival cases of ATC. In situ apoptotic cell death was analyzed by the TUNEL method. Mean Bcl-2 staining score (calculated from individual scores from 0-3) was low compared to those for Bax and survivin (p<0.05). High expression of survivin was associated with high Bax expression, and was significantly segregated from high Bcl-2 expressing cases (p<0.05). Despite high Bax expression, apoptotic cell death was low in the investigated carcinomas. In addition, the mean apoptotic index in high survivin expressing carcinomas was significantly lower than in low survivin expressing carcinomas (p<0.05). It could be concluded that down-regulation of Bcl-2 is counterbalanced by up-regulation of survivin, which may overcome the effects of high Bax expression, and, at least partly, explain the low apoptosis rate and high biological aggressiveness of ATC.

Valproic Acid Sensitizes TRAIL-Resistant Anaplastic Thyroid Carcinoma Cells to Apoptotic Cell Death

2013 ◽  
Vol 20 (S3) ◽  
pp. 716-724 ◽  
Author(s):  
Hyun-Young Cha ◽  
Bok-Soon Lee ◽  
Sam Kang ◽  
Yoo Seob Shin ◽  
Jae Won Chang ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cell Death ◽  
Thyroid Carcinoma ◽  
Apoptotic Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells

scholarly journals Synergistic Cooperation Between Sunitinib and Cisplatin Promotes Apoptotic Cell Death in Human Medullary Thyroid Cancer

2014 ◽  
Vol 99 (2) ◽  
pp. 498-509 ◽  
Author(s):  
Alessia Lopergolo ◽  
Valentina Nicolini ◽  
Enrica Favini ◽  
Laura Dal Bo ◽  
Monica Tortoreto ◽  
...  
Keyword(s):  
Cell Death ◽  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Medullary Thyroid
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