Juglone-ascorbic acid synergy inhibits metastasis and induces apoptotic cell death in poorly differentiated thyroid carcinoma by perturbing SOD and catalase activities

2018 ◽  
Vol 32 (9) ◽  
pp. e22176
Author(s):  
Sujay Gaikwad ◽  
Avik Chakraborty ◽  
Sukeshani Salwe ◽  
Vainav Patel ◽  
Savita Kulkarni ◽  
...  
Keyword(s):  
Cell Death ◽  
Ascorbic Acid ◽  
Thyroid Carcinoma ◽  
Apoptotic Cell ◽  
Differentiated Thyroid Carcinoma ◽  
Apoptotic Cell Death ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated

Unusual Finding on Ultrasonography of Follicular Thyroid Carcinoma Including Poorly Differentiated Thyroid Carcinoma

Thyroid ◽  
2008 ◽  
Vol 18 (9) ◽  
pp. 1021-1022 ◽  
Author(s):  
Minoru Kihara ◽  
Nobuyuki Amino ◽  
Mitsuyoshi Hirokawa ◽  
Fumio Matsuzuka ◽  
Akira Miyauchi
Keyword(s):  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated ◽  
Unusual Finding

scholarly journals Atypical Features Resembling Poorly Differentiated Thyroid Carcinoma Presenting Entirely within a Follicular Adenoma

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Daniel Ching ◽  
Connull Leslie
Keyword(s):  
Thyroid Carcinoma ◽  
Unusual Case ◽  
Follicular Adenoma ◽  
Differentiated Thyroid Carcinoma ◽  
Follicular Neoplasm ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Biological Potential ◽  
Poorly Differentiated ◽  
High Mitotic Count ◽  
Widely Invasive

Poorly differentiated thyroid carcinoma (PDTC) is rare and is usually widely invasive at presentation. Here we present an unusual case with a component meeting diagnostic criteria for PDTC by Turin consensus proposal arising within a follicular adenoma. A 44-year-old female was found to have an incidental right thyroid nodule that was suggestive of follicular neoplasm on FNA. Histological examination of hemithyroidectomy revealed an 11 mm focus with insular growth pattern, alteration in cell morphology, and high mitotic count meeting criteria for PDTC. In addition there were several regions showing trabecular architecture with increased mitotic activity but not meeting criteria for PDTC. The literature for such cases is sparse but suggests much better prognosis than conventional invasive PDTC, although a biological potential for aggressive behaviour may be possible.

scholarly journals Survivin in relation to Bcl-2, Bax and in situ apoptotic cell death in anaplastic thyroid carcinoma

2011 ◽  
Vol 63 (4) ◽  
pp. 955-963
Author(s):  
Sonja Selemetjev ◽  
Dubravka Cvejic ◽  
Svetlana Savin ◽  
I. Paunovic ◽  
S. Tatic
Keyword(s):  
Cell Death ◽  
Thyroid Carcinoma ◽  
Apoptotic Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Apoptotic Cell Death ◽  
Staining Score ◽  
Human Malignancy ◽  
Apoptotic Pathways ◽  
Individual Scores

Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive human malignancy. It is known that disturbances in apoptotic pathways have a great impact on tumor progression and aggressiveness. In this study the apoptosisrelated molecules Bcl-2 (antiapoptotic), Bax (proapoptotic) and survivin (an inhibitor of apoptosis) were analyzed immunohistochemically in thirty archival cases of ATC. In situ apoptotic cell death was analyzed by the TUNEL method. Mean Bcl-2 staining score (calculated from individual scores from 0-3) was low compared to those for Bax and survivin (p<0.05). High expression of survivin was associated with high Bax expression, and was significantly segregated from high Bcl-2 expressing cases (p<0.05). Despite high Bax expression, apoptotic cell death was low in the investigated carcinomas. In addition, the mean apoptotic index in high survivin expressing carcinomas was significantly lower than in low survivin expressing carcinomas (p<0.05). It could be concluded that down-regulation of Bcl-2 is counterbalanced by up-regulation of survivin, which may overcome the effects of high Bax expression, and, at least partly, explain the low apoptosis rate and high biological aggressiveness of ATC.

scholarly journals Poorly differentiated thyroid carcinoma: An institutional experience

2020 ◽  
Vol 16 (1) ◽  
pp. 25-32
Author(s):  
Seok Won Choi ◽  
Joon-Hyop Lee ◽  
Yun Young Kim ◽  
Yoo Seung Chung ◽  
Sangtae Choi ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Institutional Experience ◽  
Poorly Differentiated

A rare cause of malignant pleural effusion: Poorly differentiated thyroid carcinoma

2021 ◽  
Author(s):  
Burcak Helvaci ◽  
Gulsum Karaahmetli ◽  
Muhammet Sacikara ◽  
Seyrek Neslihan Cuhaci ◽  
Serifoglu İrem ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Thyroid Carcinoma ◽  
Malignant Pleural Effusion ◽  
Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated
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