Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1

2016 ◽  
Vol 59 ◽  
pp. 71-76 ◽  
Author(s):  
Pavla Koralkova ◽  
Renata Mojzikova ◽  
Brigitte van Oirschot ◽  
Christine Macartney ◽  
Pavel Timr ◽  
...  
Keyword(s):  
Blood Cell ◽  
Molecular Characterization ◽  
Red Blood Cell ◽  
Novel Mutations

Clinical and molecular characterization of Rubinstein-Taybi syndrome patients carrying distinct novel mutations of theEP300gene

2014 ◽  
Vol 87 (2) ◽  
pp. 148-154 ◽  
Author(s):  
G. Negri ◽  
D. Milani ◽  
P. Colapietro ◽  
F. Forzano ◽  
M. Della Monica ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Novel Mutations

Detection and characterization of red blood cell (RBC) aggregation with photoacoustics

2012 ◽  
Author(s):  
Eno Hysi ◽  
Ratan K. Saha ◽  
Min Rui ◽  
Michael C. Kolios
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Rbc Aggregation

scholarly journals Phenotypic and Molecular Characterization of Optochin-Resistant Streptococcus pneumoniae Isolates from Brazil, with Description of Five Novel Mutations in the atpC Gene

2013 ◽  
Vol 51 (10) ◽  
pp. 3242-3249 ◽  
Author(s):  
T. C. A. Pinto ◽  
A. R. V. Souza ◽  
S. E. C. M. de Pina ◽  
N. S. Costa ◽  
A. A. Borges Neto ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Molecular Characterization ◽  
Novel Mutations

scholarly journals Characterization of erythrocyte quality during the refrigerated storage of whole blood containing di-(2-ethylhexyl) phthalate

Blood ◽  
1984 ◽  
Vol 64 (6) ◽  
pp. 1270-1276 ◽  
Author(s):  
TN Estep ◽  
RA Pedersen ◽  
TJ Miller ◽  
KR Stupar
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Whole Blood ◽  
Refrigerated Storage ◽  
Cell Integrity ◽  
Normal Morphology ◽  
Plasma Hemoglobin ◽  
Induced Changes ◽  
Ethylhexyl Phthalate

Abstract Di-(2-ethylhexyl) phthalate (DEHP) accumulates in blood brought into contact with materials utilizing this compound as a plasticizer. To determine whether this phthalate diester affects red blood cell integrity, we have compared cell morphology, plasma hemoglobin accumulation, micro-vesicle production, and the concentration of intracellular metabolites and electrolytes of erythrocytes from blood stored at 4 degrees C with and without DEHP. When sufficient emulsified DEHP was mixed with blood to give a final concentration of 300 micrograms/mL, plasma hemoglobin accumulation was reduced by an average of 70%, the percentage of cells exhibiting normal morphology was enhanced by at least 20-fold, and the volume of microvesicles released from red blood cells was reduced by 50% after 35 days of refrigerated storage compared to the values obtained from corresponding samples stored without added phthalate. Similar effects were observed regardless of whether blood was stored in nonplasticized polypropylene or tri-(2-ethylhexyl) trimellitate plasticized polyvinylchloride containers and with DEHP solubilized by a variety of emulsifiers. When 300 micrograms/mL DEHP was added to stored blood containing erythrocytes predominantly in the echinocyte conformation, many of the cells reverted to the normal discoid morphology. The addition of this quantity of DEHP to blood had no significant effect on the course of storage-induced changes in erythrocyte adenosine triphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG), sodium or potassium concentrations. The data are consistent with the hypothesis that DEHP inhibits the deterioration of the red blood cell membrane that results from the refrigerated storage of whole blood.

scholarly journals Deformability based sorting of stored red blood cells reveals donor-dependent aging curves

Lab on a Chip ◽  
2020 ◽  
Vol 20 (2) ◽  
pp. 226-235 ◽  
Author(s):  
Emel Islamzada ◽  
Kerryn Matthews ◽  
Quan Guo ◽  
Aline T. Santoso ◽  
Simon P. Duffy ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Cold Storage ◽  
Red Blood Cell ◽  
Cell Sorting ◽  
Blood Cells ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Cell sorting using microfluidic ratchets enables sensitive and consistent characterization of donor red blood cell deformability. Using this capability, we show the degradation of red blood cell deformability during cold storage is donor-dependent.

S5.5. Characterization of red blood cell mechanical properties and interactions by ultrasonic interferometry

Biorheology ◽  
1995 ◽  
Vol 32 (2-3) ◽  
pp. 125-125
Author(s):  
M RAZAVIAN ◽  
M BOYNARD ◽  
R GUILLET ◽  
H MEISELMAN ◽  
Y BEUZARD
Keyword(s):  
Mechanical Properties ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Mechanical Properties ◽  
Ultrasonic Interferometry
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