Characterization of [3H]-Valinomycin binding to red blood cell membrane

1980 ◽  
Vol 6 (3) ◽  
pp. 143-147
Author(s):  
M. Herzberg ◽  
C. R. Levine
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Red Blood Cell Membrane

Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14506-14511 ◽  
Author(s):  
Maggie S. Chen ◽  
Yue Zhang ◽  
Liangfang Zhang
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Hybrid Device ◽  
Red Blood Cell Membrane ◽  
Coated Nanoparticles ◽  
Fabrication And Characterization

We report a 3D-bioprinted micro/nanodevice that encapsulates red blood cell membrane-coated nanoparticles with inner channels for biodetoxification.

Further characterization of cation channels present in the chicken red blood cell membrane

2008 ◽  
Vol 73 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Franck Lapaix ◽  
Guillaume Bouyer ◽  
Serge Thomas ◽  
Stéphane Egée
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cation Channels ◽  
Red Blood Cell Membrane

Molecular and Biocompatibility Characterization of Red Blood Cell Membrane Targeted and Cell-Penetrating-Peptide-Modified Polymeric Nanoparticles

2017 ◽  
Vol 14 (7) ◽  
pp. 2224-2235 ◽  
Author(s):  
Kaustuv Sahoo ◽  
Sriharsha Karumuri ◽  
Rangika S. Hikkaduwa Koralege ◽  
Nicholas H. Flynn ◽  
Steve Hartson ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Polymeric Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Red Blood Cell Membrane ◽  
Cell Penetrating

scholarly journals Red Blood Cell Membrane-Camouflaged Tedizolid Phosphate-Loaded PLGA Nanoparticles for Bacterial-Infection Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Membrane ◽  
Blood Cell ◽  
Sustained Release ◽  
Delivery System ◽  
Red Blood Cell ◽  
Multiple Drug Resistance ◽  
Plga Nanoparticles ◽  
Multiple Drug ◽  
Red Blood Cell Membrane

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.

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