Gum Arabic modifies anti-inflammatory cytokine in mice fed with high fat diet induced obesity

2021 ◽  
Vol 25 ◽  
pp. 100258
Author(s):  
Abdelkareem A. Ahmed ◽  
Mohammed Elmujtba Adam Essa ◽  
Adriano Mollica ◽  
Azzurra Stefanucci ◽  
Gokhan Zengin ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Inflammatory Cytokine ◽  
Gum Arabic ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 733
Author(s):  
Francisco Javier Leyva-Jiménez ◽  
Antonio Jesús Ruiz-Malagón ◽  
José Alberto Molina-Tijeras ◽  
Patricia Diez-Echave ◽  
Teresa Vezza ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Fat Diet ◽  
High Fat ◽  
Ionization Time ◽  
Flight Mass Spectrometry ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
Anti Inflammatory ◽  
Tof Ms

Increased levels of reactive oxygen species (ROS) and a low-grade chronic inflammation in multiple organs have been demonstrated in obesity. Morus alba leaves extracts (MAEs) have been used in traditional medicine as anti-inflammatory agents. In this work, the bioactive compounds of different genotypes of M. alba L. (Filipina, Valenciana Temprana, Kokuso, and Italia) were analyzed not only by reverse phase high performance liquid chromatography–electrospray ionization-time of flight-mass spectrometry (RP-HPLC-ESI-TOF-MS) and hydrophilic interaction chromatography–electrospray ionization-time of flight-mass spectrometry (HILIC-ESI-TOF-MS), but also screened for in vitro and in vivo antioxidant activity by means of DPPH• radical scavenging assay and Caenorhabditis elegans model. These MAEs were administered daily in a model of diet-induced obesity in mice. Filipina and Italia genotypes significantly reduced weight gain, the glycemic levels in high fat diet, as well as, levels of LDL-cholesterol and triglycerides. Filipina and Italia MAEs also reduced the expression of proinflammatory mediators such as Tnf-α, Il-1β, Il-6 and increased the levels of adiponectin and AMPK, which exert anti-inflammatory effects. Moreover, Italia genotype ameliorated the intestinal barrier function. In conclusion, Filipina and Italia methanolic extracts show the highest antioxidant and anti-inflammatory effect, due to the presence of compounds such as protocatechuic acid or quercetin-3-glucoside, and they could be developed as a complementary treatment for obesity and metabolic disorders.

Role of anti‐inflammatory interventions in high‐fat‐diet‐induced obesity

2020 ◽  
Vol 34 (3) ◽  
Author(s):  
Rasha Abdelmawla Ghazala ◽  
Azza El Medney ◽  
Anisa Meleis ◽  
Passant Mohie El dien ◽  
Hend Samir
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Anti Inflammatory

Anti-inflammatory and antiobesity effects of mulberry leaf and fruit extract on high fat diet-induced obesity

2013 ◽  
Vol 238 (10) ◽  
pp. 1160-1169 ◽  
Author(s):  
Hyun Hwa Lim ◽  
Sung Ok Lee ◽  
Sun Yeou Kim ◽  
Soo Jin Yang ◽  
Yunsook Lim
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Fruit Extract ◽  
Mulberry Leaf ◽  
Diet Induced Obesity ◽  
Anti Inflammatory

Anti-inflammatory effect of β2 adrenergic stimulation on circulating monocytes with a pro-inflammatory state in high-fat diet-induced obesity

2019 ◽  
Vol 80 ◽  
pp. 564-572 ◽  
Author(s):  
Isabel Gálvez ◽  
Leticia Martín-Cordero ◽  
María Dolores Hinchado ◽  
Alberto Álvarez-Barrientos ◽  
Eduardo Ortega
Keyword(s):  
High Fat Diet ◽  
Adrenergic Stimulation ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 23 ◽  
Author(s):  
Tetiana Halenova ◽  
Igor Zlatskiy ◽  
Anton Syroeshkin ◽  
Tatiana Maximova ◽  
Tatiana Pleteneva
Keyword(s):  
Oxidative Stress ◽  
Proinflammatory Cytokines ◽  
High Fat Diet ◽  
Antioxidant Enzyme Activities ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Deuterium Depleted Water ◽  
Anti Inflammatory ◽  
Treatment Of Obesity ◽  
Body Weight Index

In this study, we present the potential application of deuterium-depleted water (DDW) for the prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver. Drinking DDW at a concentration of 10 ppm deuterium/protium (D/H) ad libitum for 3 weeks restored the BWI, glucose (serum), tryptophan (brain), and serotonin (brain) levels and concentration of Zn in the liver in the DIO animals to those of the controls. The levels of proinflammatory cytokines (IL-1β, IL-6, IFNγ) and anti-inflammatory TNFα were decreased in DIO rats, while anti-inflammatory cytokine (IL-4, IL-10) levels remained at the control levels, which is indicative of a pathophysiological syndrome. In contrast, in groups of rats treated with DDW, a significant increase in anti-inflammatory (IL-4, IL-10) and proinflammatory cytokines (IFNγ) was observed. This finding indicates a reduction in systemic inflammation in obese animals treated with DDW. Similarly, the high-fat diet caused an increased level of oxidative stress products, which was accompanied by decreased activity of both superoxide dismutase and catalase, whereas the administration of DDW decreased the level of oxidative stress and enhanced antioxidant enzyme activities.

scholarly journals Anti-inflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity

2011 ◽  
Vol 335 (2) ◽  
pp. 110-115 ◽  
Author(s):  
Demétrius P. Arçari ◽  
Waldemar Bartchewsky ◽  
Tanila W. dos Santos ◽  
Karim A. Oliveira ◽  
Carlorine C. DeOliveira ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Fat Diet ◽  
Ilex Paraguariensis ◽  
Yerba Mate ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Anti Inflammatory ◽  
Ameliorate Insulin Resistance
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