Integrin-linked kinase is a positive mediator of L6 myoblast differentiation

2003 ◽  
Vol 310 (3) ◽  
pp. 796-803 ◽  
Author(s):  
Mathew G Miller ◽  
Izabela Naruszewicz ◽  
Ashu S Kumar ◽  
Toolsie Ramlal ◽  
Gregory E Hannigan
Keyword(s):  
Myoblast Differentiation ◽  
Integrin Linked Kinase ◽  
L6 Myoblast

scholarly journals Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation

2013 ◽  
Vol 228 (10) ◽  
pp. 1989-1995 ◽  
Author(s):  
Yulan Jiang ◽  
Pavneet Singh ◽  
Hao Yin ◽  
Yi-Xia Zhou ◽  
Yu Gui ◽  
...  
Keyword(s):  
Myoblast Differentiation ◽  
L6 Myoblast

Biphasic concentration dependency of stimulation of myoblast differentiation by somatomedins

1986 ◽  
Vol 250 (5) ◽  
pp. C771-C778 ◽  
Author(s):  
J. R. Florini ◽  
D. Z. Ewton ◽  
S. L. Falen ◽  
J. J. Van Wyk
Keyword(s):  
Growth Factor ◽  
Myoblast Differentiation ◽  
Medium Components ◽  
Low Concentrations ◽  
Concentration Dependency ◽  
Epidermal Growth ◽  
L6 Myoblast ◽  
Stimulation Of ◽  
Insulin Like Growth Factors

It is widely believed that mitogens inhibit in vitro differentiation of myoblasts to form postmitotic myotubes, but we and others have shown that the mitogenic hormones insulin and the insulin-like growth factors (IGFs) stimulate myoblast differentiation. We now report the results of concentration-dependency studies that resolve this disagreement. We found that the IGFs give a biphasic dose-response curve; at low concentrations, there is progressive stimulation of L6 myoblast differentiation; at higher concentrations, there is a progressive decrease. Similar results were obtained with IGF-II and insulin. When differentiation was maximally stimulated (by 1,280 ng/ml insulin), adding rat IGF-II gave decreases in differentiation similar to those reported for other mitogens. Two trivial explanations have been eliminated: stimulation of differentiation (at low concentrations) is not due to enhanced survival or growth of the cells, and inhibition (at higher concentrations) is not a toxic effect. In L6 cells, epidermal growth factor and fibroblast growth factor had no effect on proliferation or differentiation. We conclude that the effects of medium components on myoblast differentiation cannot be generalized to indicate inhibition by all mitogens; depending on the cell lines and concentrations used, certain mitogens may either stimulate or inhibit differentiation.

1944-P: Muscle a-Parvin Is Not Necessary for Integrin-Linked Kinase Related Insulin Resistance in Diet-Induced Obese Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1944-P
Author(s):  
DAVID A. CAPPEL ◽  
AMBRA POZZI ◽  
ROY ZENT ◽  
DAVID WASSERMAN
Keyword(s):  
Insulin Resistance ◽  
Obese Mice ◽  
Integrin Linked Kinase
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