Excitotoxic lesion of the perirhinal cortex impairs spatial working memory in a delayed-alternation task

2012 ◽  
Vol 230 (2) ◽  
pp. 349-354 ◽  
Author(s):  
Silvia Maioli ◽  
Giuseppe Gangarossa ◽  
Federica Locchi ◽  
Anna Andrioli ◽  
Giuseppe Bertini ◽  
...  
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Perirhinal Cortex ◽  
Delayed Alternation ◽  
Excitotoxic Lesion ◽  
Delayed Alternation Task ◽  
Alternation Task

Increase of Extracellular Dopamine in Primate Prefrontal Cortex During a Working Memory Task

1997 ◽  
Vol 78 (5) ◽  
pp. 2795-2798 ◽  
Author(s):  
Masataka Watanabe ◽  
Tohru Kodama ◽  
Kazuo Hikosaka
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Cognitive Processes ◽  
Memory Task ◽  
Dopamine Level ◽  
Control Task ◽  
Extracellular Dopamine ◽  
Delayed Alternation ◽  
Delayed Alternation Task ◽  
Alternation Task

Watanabe, Masataka, Tohru Kodama, and Kazuo Hikosaka. Increase of extracellular dopamine in primate prefrontal cortex during a working memory task. J. Neurophysiol. 78: 2795–2798, 1997. The dopamine innervation of the prefrontal cortex is involved importantly in cognitive processes, such as tested in working memory tasks. However, there have been no studies directly investigating prefrontal dopamine levels in relation to cognitive processes. We measured frontal extracellular dopamine concentration using in vivo microdialysis in monkeys performing in a delayed alternation task as a typical working memory paradigm and in a sensory-guided control task. We observed a significant increase in dopamine level in the delayed alternation task as compared both with the sensory-guided control task and the basal resting level. The increase was seen in the dorsolateral prefrontal but not in the arcuate or orbitofrontal areas. The increase appeared to reflect the working memory component of the task and was observed mainly in the lip areas of principal sulcus. Although there was no significant difference in dopamine level between delayed alternation and sensory-guided control tasks in the premotor area, significant increases in dopamine concentration were observed during both tasks as compared with the basal resting level, indicating the importance of premotor dopamine for the motor response itself.

Anisomycin impairs long-term working memory in a delayed alternation task

1987 ◽  
Vol 47 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sheri J.Y. Mizumori ◽  
Veena Channon ◽  
Mark R. Rosenzweig ◽  
Edward L. Bennett
Keyword(s):  
Working Memory ◽  
Delayed Alternation ◽  
Long Term Working Memory ◽  
Delayed Alternation Task ◽  
Alternation Task

Effects of rat medial prefrontal cortex temporal inactivation on a delayed alternation task

2001 ◽  
Vol 315 (3) ◽  
pp. 129-132 ◽  
Author(s):  
Yoshinori Izaki ◽  
Kiyoyuki Maruki ◽  
Koji Hori ◽  
Masahiko Nomura
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Delayed Alternation ◽  
Delayed Alternation Task ◽  
Alternation Task
Sign in / Sign up

Export Citation Format

Share Document