scholarly journals Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study

2012 ◽  
Vol 26 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Hyong Jin Cho ◽  
Julienne E. Bower ◽  
Catarina I. Kiefe ◽  
Teresa E. Seeman ◽  
Michael R. Irwin
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

scholarly journals Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population

2021 ◽  
Author(s):  
Rebecka Keijser ◽  
Susanne Olofsdotter ◽  
Kent W. Nilsson ◽  
Cecilia Åslund
Keyword(s):  
Young Adults ◽  
Depressive Symptoms ◽  
Life Stress ◽  
Early Life ◽  
Differential Susceptibility ◽  
Early Life Stress ◽  
Interaction Effects ◽  
Positive Parenting ◽  
Depressive Symptomology ◽  
Patterns Of Interaction

AbstractFKBP5 gene–environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQpos), through the frameworks of the diathesis stress and differential susceptibility theorem. Data were obtained from the Survey of Adolescent Life in Västmanland Cohort Study, including 1006 participants and their guardians. Data were collected during 2012, when the participants were 13 and 15 years old (Wave I: DNA), 2015, when participants were 16 and 18 years old (Wave II: PASCQpos, depressive symptomology and ELS) and 2018, when participants were 19 and 21 years old (Wave III: depressive symptomology). Significant three-way interactions were found for the FKBP5 SNPs rs1360780, rs4713916, rs7748266 and rs9394309, moderated by ELS and PASCQpos, on depressive symptoms among young adults. Diathesis stress patterns of interaction were observed for the FKBP5 SNPs rs1360780, rs4713916 and rs9394309, and differential susceptibility patterns of interaction were observed for the FKBP5 SNP rs7748266. Findings emphasize the possible role of FKBP5 in the development of depressive symptoms among young adults and contribute to the understanding of possible differential susceptibility effects of FKBP5.

Early life stress predicts cortisol response to psychosocial stress in healthy young adults

PsyCh Journal ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 353-362 ◽  
Author(s):  
Huihui Zhang ◽  
Zhuxi Yao ◽  
Li Lin ◽  
Xiaofang Sun ◽  
Xia Shi ◽  
...  
Keyword(s):  
Young Adults ◽  
Life Stress ◽  
Early Life ◽  
Psychosocial Stress ◽  
Early Life Stress ◽  
Cortisol Response

Early Life Stress is a Risk Factor for Bipolar Disorder: A Prospective Cohort Study of Young Adults

2021 ◽  
Vol 89 (9) ◽  
pp. S315
Author(s):  
Taiane Cardoso ◽  
Júlia Bierhals Bilhalva ◽  
Amanda Rodrigues Fialho ◽  
Mariana Pouey da Cunha ◽  
Thierry Berny ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young Adults ◽  
Risk Factor ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Life Stress ◽  
Prospective Cohort ◽  
Early Life ◽  
Early Life Stress

The effects of early life stress on context fear generalization in adult rats.

2019 ◽  
Vol 133 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Nathalie D. Elliott ◽  
Rick Richardson
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Rats ◽  
Fear Generalization

Neurobiology of early life stress: Rodent studies

2002 ◽  
Vol 7 (2) ◽  
pp. 89-95 ◽  
Author(s):  
David A Gutman ◽  
Charles B. Nemeroff
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress
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