Faculty Opinions recommendation of Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study.

Author(s):  
Irene Yen
2012 ◽  
Vol 26 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Hyong Jin Cho ◽  
Julienne E. Bower ◽  
Catarina I. Kiefe ◽  
Teresa E. Seeman ◽  
Michael R. Irwin

2012 ◽  
Vol 126 (6) ◽  
pp. 402-410 ◽  
Author(s):  
L. L. Carpenter ◽  
C. E. Gawuga ◽  
A. R. Tyrka ◽  
L. H. Price

2009 ◽  
Vol 28 (3) ◽  
pp. 338-346 ◽  
Author(s):  
Barbara J. Lehman ◽  
Shelley E. Taylor ◽  
Catarina I. Kiefe ◽  
Teresa E. Seeman

Author(s):  
Rebecka Keijser ◽  
Susanne Olofsdotter ◽  
Kent W. Nilsson ◽  
Cecilia Åslund

AbstractFKBP5 gene–environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQpos), through the frameworks of the diathesis stress and differential susceptibility theorem. Data were obtained from the Survey of Adolescent Life in Västmanland Cohort Study, including 1006 participants and their guardians. Data were collected during 2012, when the participants were 13 and 15 years old (Wave I: DNA), 2015, when participants were 16 and 18 years old (Wave II: PASCQpos, depressive symptomology and ELS) and 2018, when participants were 19 and 21 years old (Wave III: depressive symptomology). Significant three-way interactions were found for the FKBP5 SNPs rs1360780, rs4713916, rs7748266 and rs9394309, moderated by ELS and PASCQpos, on depressive symptoms among young adults. Diathesis stress patterns of interaction were observed for the FKBP5 SNPs rs1360780, rs4713916 and rs9394309, and differential susceptibility patterns of interaction were observed for the FKBP5 SNP rs7748266. Findings emphasize the possible role of FKBP5 in the development of depressive symptoms among young adults and contribute to the understanding of possible differential susceptibility effects of FKBP5.


2021 ◽  
Vol 9 ◽  
Author(s):  
Zsofia P. Cohen ◽  
Kelly T. Cosgrove ◽  
Danielle C. DeVille ◽  
Elisabeth Akeman ◽  
Manpreet K. Singh ◽  
...  

Background: The COVID-19 pandemic has brought on far-reaching consequences for adolescents. Adolescents with early life stress (ELS) may be at particular risk. We sought to examine how COVID-19 impacted psychological functioning in a sample of healthy and ELS-exposed adolescents during the pandemic.Methods: A total of 24 adolescents (15 healthy, nine ELS) completed self-report measures prior to and during the COVID-19 pandemic. The effect of COVID-19 on symptoms of depression and anxiety were explored using linear mixed-effect analyses.Results: With the onset of the pandemic, healthy but not ELS-exposed adolescents evidenced increased symptoms of depression and anxiety (ps < 0.05). Coping by talking with friends and prioritizing sleep had a protective effect against anxiety for healthy adolescents (t = −3.76, p = 0.002).Conclusions: On average, this study demonstrated large increases in depression and anxiety in adolescents who were healthy prior to the COVID-19 pandemic, while ELS-exposed adolescents evidenced high but stable symptoms over time.


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