Early life stress predicts cortisol response to psychosocial stress in healthy young adults

PsyCh Journal ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 353-362 ◽  
Author(s):  
Huihui Zhang ◽  
Zhuxi Yao ◽  
Li Lin ◽  
Xiaofang Sun ◽  
Xia Shi ◽  
...  
Keyword(s):  
Young Adults ◽  
Life Stress ◽  
Early Life ◽  
Psychosocial Stress ◽  
Early Life Stress ◽  
Cortisol Response

scholarly journals Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population

2021 ◽  
Author(s):  
Rebecka Keijser ◽  
Susanne Olofsdotter ◽  
Kent W. Nilsson ◽  
Cecilia Åslund
Keyword(s):  
Young Adults ◽  
Depressive Symptoms ◽  
Life Stress ◽  
Early Life ◽  
Differential Susceptibility ◽  
Early Life Stress ◽  
Interaction Effects ◽  
Positive Parenting ◽  
Depressive Symptomology ◽  
Patterns Of Interaction

AbstractFKBP5 gene–environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQpos), through the frameworks of the diathesis stress and differential susceptibility theorem. Data were obtained from the Survey of Adolescent Life in Västmanland Cohort Study, including 1006 participants and their guardians. Data were collected during 2012, when the participants were 13 and 15 years old (Wave I: DNA), 2015, when participants were 16 and 18 years old (Wave II: PASCQpos, depressive symptomology and ELS) and 2018, when participants were 19 and 21 years old (Wave III: depressive symptomology). Significant three-way interactions were found for the FKBP5 SNPs rs1360780, rs4713916, rs7748266 and rs9394309, moderated by ELS and PASCQpos, on depressive symptoms among young adults. Diathesis stress patterns of interaction were observed for the FKBP5 SNPs rs1360780, rs4713916 and rs9394309, and differential susceptibility patterns of interaction were observed for the FKBP5 SNP rs7748266. Findings emphasize the possible role of FKBP5 in the development of depressive symptoms among young adults and contribute to the understanding of possible differential susceptibility effects of FKBP5.

scholarly journals Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study

2012 ◽  
Vol 26 (6) ◽  
pp. 859-865 ◽  
Author(s):  
Hyong Jin Cho ◽  
Julienne E. Bower ◽  
Catarina I. Kiefe ◽  
Teresa E. Seeman ◽  
Michael R. Irwin
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

scholarly journals Early Life Stress Enhances the Vulnerability to Chronic Psychosocial Stress and Experimental Colitis in Adult Mice

Endocrinology ◽  
2008 ◽  
Vol 149 (6) ◽  
pp. 2727-2736 ◽  
Author(s):  
Alexa H. Veenema ◽  
Stefan O. Reber ◽  
Sandra Selch ◽  
Florian Obermeier ◽  
Inga D. Neumann
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Psychosocial Stress ◽  
Early Life Stress ◽  
Experimental Colitis ◽  
Adult Mice ◽  
Chronic Psychosocial Stress

scholarly journals Amygdala–Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin

2015 ◽  
Vol 40 (12) ◽  
pp. 2736-2744 ◽  
Author(s):  
Yan Fan ◽  
Karin Pestke ◽  
Melanie Feeser ◽  
Sabine Aust ◽  
Jens C Pruessner ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Psychosocial Stress ◽  
Early Life Stress ◽  
Joint Effect ◽  
Acute Psychosocial Stress

scholarly journals The 5-HTTLPR genotype, early life adversity and cortisol responsivity to psychosocial stress in women

BJPsych Open ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 180-185 ◽  
Author(s):  
Jurate Aleknaviciute ◽  
Joke H. M. Tulen ◽  
Yolanda B. de Rijke ◽  
Mark van der Kroeg ◽  
Cornelis G. Kooiman ◽  
...  
Keyword(s):  
Childhood Maltreatment ◽  
Life Stress ◽  
Early Life ◽  
Psychosocial Stress ◽  
Social Stress ◽  
Stress Test ◽  
Early Life Stress ◽  
Trier Social Stress Test ◽  
Early Life Adversity ◽  
Personality Psychopathology

BackgroundThe serotonin transporter gene-linked polymorphic region (5-HTTLPR) has previously been associated with hypothalamus–pituitary–adrenal axis function. Moreover, it has been suggested that this association is moderated by an interaction with stressful life experiences.AimsTo investigate the moderation of cortisol response to psychosocial stress by 5-HTTLPR genotype, either directly or through an interaction with early life stress.MethodA total of 151 women, 85 of which had personality psychopathology, performed the Trier Social Stress Test while cortisol responsivity was assessed.ResultsThe results demonstrate a main effect of genotype on cortisol responsivity. Women carrying two copies of the long version of 5-HTTLPR exhibited stronger cortisol responses to psychosocial stress than women with at least one copy of the short allele (P = 0.03). However, the proportion of the variance of stress-induced cortisol responsivity explained by 5-HTTLPR genotype was not further strengthened by including early life adversity as a moderating factor (P = 0.52).ConclusionsOur results highlight the need to clarify gender-specific biological factors influencing the serotonergic system. Furthermore, our results suggest that childhood maltreatment, specifically during the first 15 years of life, is unlikely to exert a moderating influence of large effect on the relationship between the 5-HTTLPR genotype and cortisol responsivity to psychosocial stress.Declaration of interestNone.

Early Life Stress is a Risk Factor for Bipolar Disorder: A Prospective Cohort Study of Young Adults

2021 ◽  
Vol 89 (9) ◽  
pp. S315
Author(s):  
Taiane Cardoso ◽  
Júlia Bierhals Bilhalva ◽  
Amanda Rodrigues Fialho ◽  
Mariana Pouey da Cunha ◽  
Thierry Berny ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young Adults ◽  
Risk Factor ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Life Stress ◽  
Prospective Cohort ◽  
Early Life ◽  
Early Life Stress
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