scholarly journals The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

2014 ◽  
Vol 1845 (2) ◽  
pp. 232-247 ◽  
Author(s):  
Leonardo Vinícius Monteiro de Assis ◽  
Jamille Locatelli ◽  
Mauro César Isoldi
Keyword(s):  
Malignant Mesothelioma ◽  
Key Genes

The Role of CD90 in the Differential Diagnosis of Pleural Malignant Mesothelioma, Pulmonary Carcinoma and Comparison with Calretının

2016 ◽  
Vol 23 (3) ◽  
pp. 487-491 ◽  
Author(s):  
Nurhan Sahin ◽  
Ayse Nur Akatli ◽  
Muhammet Reha Celik ◽  
Hakkı Ulutas ◽  
Emine Turkmen Samdanci ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Pulmonary Carcinoma ◽  
Pleural Malignant Mesothelioma

scholarly journals Novel Reiterated Fnr-Type Proteins Control the Production of the Symbiotic Terminal Oxidase cbb3 in Rhizobium etli CFN42

2007 ◽  
Vol 20 (10) ◽  
pp. 1241-1249 ◽  
Author(s):  
Manuel J. Granados-Baeza ◽  
Nicolás Gómez-Hernández ◽  
Yolanda Mora ◽  
María J. Delgado ◽  
David Romero ◽  
...  
Keyword(s):  
Nitrogen Fixation ◽  
Oxygen Affinity ◽  
Structural Similarity ◽  
Transcriptional Regulators ◽  
Terminal Oxidase ◽  
Nitrogen Fixing ◽  
Rhizobium Etli ◽  
High Oxygen Affinity ◽  
Key Genes

Symbiotic nitrogen-fixing bacteria express a terminal oxidase with a high oxygen affinity, the cbb3-type oxidase encoded by the fixNOQP operon. Previously, we have shown that, in Rhizobium etli CFN42, the repeated fixNOQP operons (fixNOQPd and fixNOQPf) have a differential role in nitrogen fixation. Only the fixNOQPd operon is required for the establishment of an effective symbiosis; microaerobic induction of this operon is under the control of at least three transcriptional regulators, FixKf, FnrNd, and FnrNchr, belonging to the Crp/Fnr family. In this work, we describe two novel Crp/Fnr-type transcriptional regulators (StoRd and StoRf, symbiotic terminal oxidase regulators) that play differential roles in the control of key genes for nitrogen fixation. Mutations either in stoRd or stoRf enhance the microaerobic expression of both fixNOQP reiterations, increasing also the synthesis of the cbb3-type oxidase in nodules. Despite their structural similarity, a differential role of these genes was also revealed, since a mutation in stoRd but not in stoRf enhanced both the expression of fixKf and the nitrogen-fixing capacity of R. etli CFN42.

The role of key genes in astaxanthin biosynthesis in Phaffia rhodozyma by transcript level and gene knockout

2021 ◽  
Author(s):  
Zhipeng Li ◽  
Lina Chen ◽  
Haoyi Yang ◽  
Tianli Li ◽  
Xiping Du ◽  
...  
Keyword(s):  
Gene Knockout ◽  
Transcript Level ◽  
Phaffia Rhodozyma ◽  
Key Genes

scholarly journals Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism

2011 ◽  
Vol 286 (22) ◽  
pp. 19478-19488 ◽  
Author(s):  
Linda Nocchi ◽  
Marco Tomasetti ◽  
Monica Amati ◽  
Jiri Neuzil ◽  
Lory Santarelli ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Malignant Mesothelioma ◽  
Promoter Methylation ◽  
Dna Methyltransferase ◽  
Critical Role ◽  
Gene Promoter ◽  
Epigenetic Mechanism ◽  
Heterogeneous Expression ◽  
High Level

Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process. Heterogeneous expression of TM has been observed in cancer, and low or no TM expression in cancer cells is associated with poor prognosis. In this study, we analyzed TM expression in biopsies of MM patients and compared them with normal mesothelial tissue. The role of DNA methylation-associated gene silencing in TM expression was investigated. To evaluate poly(ADP-ribose) polymerase-1 (PARP1) as responsible for gene promoter epigenetic modifications, nonmalignant mesothelial cells (Met-5A) and MM cells (H28) were silenced for PARP1 and the DNA methylation/acetylation-associated TM expression evaluated. A correlation between low TM expression and high level of TM promoter methylation was found in MM biopsies. Low expression of TM was restored in MM cells by their treatment with 5-aza-2′-deoxycytidine and, to a lesser extent, with trichostatin, whereas the epigenetic agents did not affect TM expression in Met-5A cells. Silencing of PARP1 resulted in a strong down-regulation of TM expression in Met-5A cells, while restoring TM expression in H28 cells. PARP1 silencing induced TM promoter methylation in Met-5A cells and demethylation in MM cells, and this was paralleled by corresponding changes in the DNA methyltransferase activity. We propose that methylation of the TM promoter is responsible for silencing of TM expression in MM tissue, a process that is regulated by PARP1.

scholarly journals CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans

2017 ◽  
Vol 74 (8) ◽  
pp. 1198-1205 ◽  
Author(s):  
Huaihan Cai ◽  
Ineke Dhondt ◽  
Lieselot Vandemeulebroucke ◽  
Caroline Vlaeminck ◽  
Madina Rasulova ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Dietary Restriction ◽  
Gabaergic Neurons ◽  
Creb Binding Protein ◽  
Axenic Medium ◽  
Life Span Extension ◽  
Gene Functions ◽  
Key Genes

Abstract When cultured in axenic medium, Caenorhabditis elegans shows the largest life-span extension compared with other dietary restriction regimens. However, the underlying molecular mechanism still remains elusive. The gene cbp-1, encoding the worm ortholog of p300/CBP (CREB-binding protein), is one of the very few key genes known to be essential for life span doubling under axenic dietary restriction (ADR). By using tissue-specific RNAi, we found that cbp-1 expression in the germline is essential for fertility, whereas this gene functions specifically in the GABAergic neurons to support the full life span–doubling effect of ADR. Surprisingly, GABA itself is not required for ADR-induced longevity, suggesting a role of neuropeptide signaling. In addition, chemotaxis assays illustrate that neuronal inactivation of CBP-1 affects the animals’ food sensing behavior. Together, our results show that the strong life-span extension in axenic medium is under strict control of GABAergic neurons and may be linked to food sensing.

99 Role of notch signaling in human malignant mesothelioma

Lung Cancer ◽  
2006 ◽  
Vol 54 ◽  
pp. S24
Author(s):  
I. Graziani ◽  
M.A. De Marco ◽  
Y. Chen ◽  
R.M. DeMay ◽  
H.I. Pass ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Malignant Mesothelioma

scholarly journals P3.03-009 Role of microRNAs as Biomarkers of Malignant Mesothelioma in Patients with Pleural Effusion

2017 ◽  
Vol 12 (1) ◽  
pp. S1348-S1349
Author(s):  
Alessandro Palleschi ◽  
Valentina Bollati ◽  
Chiara Favero ◽  
Carolina Mensi ◽  
Claudia Bareggi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Mesothelioma
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