scholarly journals P3.03-009 Role of microRNAs as Biomarkers of Malignant Mesothelioma in Patients with Pleural Effusion

2017 ◽  
Vol 12 (1) ◽  
pp. S1348-S1349
Author(s):  
Alessandro Palleschi ◽  
Valentina Bollati ◽  
Chiara Favero ◽  
Carolina Mensi ◽  
Claudia Bareggi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Mesothelioma

scholarly journals The role of cytological evaluation of pleural fluid in diagnosing malignant mesothelioma

2012 ◽  
Vol 65 (1-2) ◽  
pp. 5-8
Author(s):  
Aleksandra Lovrenski ◽  
Milana Panjkovic ◽  
Dragana Tegeltija ◽  
Ljiljana Tadic-Latinovic ◽  
Jelena Krcedinac
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Mesothelioma ◽  
Lung Diseases ◽  
Clinical Symptoms ◽  
X Rays ◽  
Malignant Cells ◽  
Cytological Evaluation ◽  
Low Sensitivity

Malignant mesothelioma is the most significant pleural tumour and it can be divided into three types: epithelial, sarcomatoid and biphasic mesothelioma. The most significant clinical manifestation of this tumour is pleural effusion. This paper was aimed at determining the role of cytological evaluation of pleural fluid in the diagnosis of malignant mesothelioma. This retrospective study included 33 medical records of patients with pleural malignant mesothelioma referred to the Institute for Lung Diseases of Vojvodina, in Sremska Kamenica in the period from 2004 to 2009. In 24 out of 33 patients, x-rays confirmed pleural effusion, thoracentesis was performed and specimens of effusion were cytologically examined at the Department of Pathology of the Institute for Lung Diseases of Vojvodina. Forty-nine cytological examinations were done. Only 2 of the first specimens were positive for malignant cells and 6 were suspicious. In repeated cytological examinations, 5 out of 6 initially suspicious specimens were positive for malignant cells, and the remaining 1 was negative. To sum up, 7 of 49 cytological examinations were positive and the sensitivity of our cytological study for the diagnosis of malignancy was 29%. Due to the low sensitivity of the cytological examinations, it has been recommended to perform biopsy of the pleura for definitive diagnosis in every patient with clinical symptoms and suspicious radiography.

scholarly journals Microfilarae in malignant mesothelioma associated pleural effusion with blood microfilaremia: a rare association

2019 ◽  
Vol 6 (4) ◽  
pp. 1349
Author(s):  
Dinesh Chandra Sharma ◽  
Deepanjali Sharma
Keyword(s):  
Pleural Effusion ◽  
Malignant Mesothelioma ◽  
Wide Spectrum ◽  
Peripheral Eosinophilia ◽  
Rare Association ◽  
Blood Smears ◽  
Peripheral Blood Smears ◽  
Eosinophil Counts ◽  
Fluid Cytology

Filariasis has a wide spectrum of presentation and usually involves the lung in the form of tropical pulmonary eosinophilia with pulmonary infiltrates and peripheral eosinophilia. Filariasis presenting with pleural effusion is an unusual presentation. Malignancy in association with filarial pleural effusion is extremely rare. In this context, we hereby report a case of 45 year old male who presented with right sided chest pain, cough, fever and generalized weakness. Pleural fluid cytology revealed microfilaria and pleural biopsies from pleural nodules confirmed malignant mesothelioma. Peripheral blood smears taken at night exhibited microfilaria with normal eosinophil counts, which is further uncommon.  Role of filariasis in tumorigenesis is controversial. 

scholarly journals Pleural Fluid Mesothelin as an Adjunct to the Diagnosis of Pleural Malignant Mesothelioma

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jenette Creaney ◽  
Amanda Segal ◽  
Nola Olsen ◽  
Ian M. Dick ◽  
A. W(Bill) Musk ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Clinical Diagnosis ◽  
Malignant Mesothelioma ◽  
Definitive Diagnosis ◽  
Malignant Cells ◽  
Clinical Value ◽  
Clinical Role ◽  
Pleural Malignant Mesothelioma ◽  
Malignant Diagnosis

Rationale. The diagnosis of pleural malignant mesothelioma (MM) by effusion cytology may be difficult and is currently controversial. Effusion mesothelin levels are increased in patients with MM but the clinical role of this test is uncertain.Objectives. To determine the clinical value of measuring mesothelin levels in pleural effusion supernatant to aid diagnosis of MM.Methods and Measurements. Pleural effusion samples were collected prospectively from 1331 consecutive patients. Mesothelin levels were determined by commercial ELISA in effusions and their relationship to concurrent pathology reporting and final clinical diagnosis was determined.Results. 2156 pleural effusion samples from 1331 individuals were analysed. The final clinical diagnosis was 183 MM, 436 non-MM malignancy, and 712 nonmalignant effusions. Effusion mesothelin had a sensitivity of 67% for MM at 95% specificity. Mesothelin was elevated in over 47% of MM cases in effusions obtained before definitive diagnosis of MM was established. In the setting of inconclusive effusion cytology, effusion mesothelin had a positive predictive value of 79% for MM and 94% for malignancy.Conclusions. A mesothelin-positive pleural effusion, irrespective of the identification of malignant cells, indicates the likely presence of malignancy and adds weight to the clinical rationale for further investigation to establish a malignant diagnosis.

scholarly journals The Role of Immunohistochemistry Studies in Distinguishing Malignant Mesothelioma from Metastatic Lung Carcinoma in Malignant Pleural Effusion

2019 ◽  
Vol 14 (02) ◽  
pp. 122-126 ◽  
Author(s):  
Monireh Halimi ◽  
◽  
Samad BeheshtiRouy ◽  
Davood Salehi ◽  
Seyed Ziaeddin Rasihashemi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Mesothelioma ◽  
Lung Carcinoma ◽  
Malignant Pleural Effusion ◽  
Metastatic Lung ◽  
Metastatic Lung Carcinoma

scholarly journals Role of chest radiograph in MERS-Cov pneumonia: a single tertiary referral center experience in the United Arab Emirates

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Karuna M. Das ◽  
Jamal Aldeen Alkoteesh ◽  
Mohamud Sheek-Hussein ◽  
Samira Ali Alzadjali ◽  
Mariam Tareq Alafeefi ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
United Arab Emirates ◽  
Chest Radiograph ◽  
Strong Predictor ◽  
Ground Glass ◽  
Tertiary Referral Center ◽  
Unit Management ◽  
Radiographic Score ◽  
Progression Of Disease

Abstract Background The Middle East respiratory syndrome coronavirus (MERS-Cov) continues to be a source of concern due to intermittent outbreaks. Serial chest radiographic changes in MERS-Cov patients were analyzed for various variables that could be compared to the patients’ final outcomes in a cluster of MERS-Cov patients and to identify a predictor of mortality in the United Arab Emirates. Results A total of 44 MERS-Cov cases were reviewed. The mean age of the patients was 43.7 ± 14.7 years. The chest radiograph was abnormal in 14/44 (31.8%). The commonest radiology features include ground-glass opacities (seven of 14, 50%), ground-glass and consolidation (seven of 14, 50%), pleural effusion (eight of 14, 57.1%), and air bronchogram (three of 14, 21.4%). The mortality rate was 13.6% (six of 44); the deceased group (6 of 44, 13.6%) was associated with significantly higher incidence of mechanical ventilation (p < 0.001), pleural effusion (p < 0.001), chest radiographic score (8.90 ± 6.31, p < 0.001), and type 4 radiographic progression of disease (p < 0.001). A chest radiographic score at presentation was seen to be an independent and strong predictor of mortality (OR [95% confidence interval] 3.20 [1.35, 7.61]). The Cohen κ coefficient for the interobserver agreement was k = 0.89 (p = 0.001). Conclusion The chest radiographic score, associated with a higher degree of disease progression (type 4), particularly in patients with old age or with comorbidity, may indicate a poorer prognosis in MERS-Cov infection, necessitating intensive care unit management or predicting impending death.

Small orangiophilic squamous-like cells: An underrecognized and useful morphological feature for the diagnosis of malignant mesothelioma in pleural effusion cytology

2013 ◽  
Vol 122 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Longwen Chen ◽  
Sonia Gatius Caldero ◽  
Stephen Gmitro ◽  
Maxwell L. Smith ◽  
Giovanni De Petris ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Mesothelioma ◽  
Morphological Feature

scholarly journals Pleural Effusion of Patients with Malignant Mesothelioma Induces Macrophage-Mediated T Cell Suppression

2016 ◽  
Vol 11 (10) ◽  
pp. 1755-1764 ◽  
Author(s):  
Lysanne A. Lievense ◽  
Robin Cornelissen ◽  
Koen Bezemer ◽  
Margaretha E.H. Kaijen-Lambers ◽  
Joost P.J.J. Hegmans ◽  
...  
Keyword(s):  
T Cell ◽  
Pleural Effusion ◽  
Malignant Mesothelioma ◽  
T Cell Suppression ◽  
Cell Suppression

scholarly journals The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

2014 ◽  
Vol 1845 (2) ◽  
pp. 232-247 ◽  
Author(s):  
Leonardo Vinícius Monteiro de Assis ◽  
Jamille Locatelli ◽  
Mauro César Isoldi
Keyword(s):  
Malignant Mesothelioma ◽  
Key Genes
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