Epigenetic mechanisms are behind the regulation of the key genes associated with the osteoblastic differentiation of the mesenchymal stem cells: The role of zoledronic acid on tuning the epigenetic changes

2019 ◽  
Vol 234 (9) ◽  
pp. 15108-15122 ◽  
Author(s):  
Faroogh Marofi ◽  
Ali Hassanzadeh ◽  
Saeed Solali ◽  
Ghasem Vahedi ◽  
Reza Mousavi Ardehaie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Zoledronic Acid ◽  
Osteoblastic Differentiation ◽  
Epigenetic Mechanisms ◽  
Epigenetic Changes ◽  
Key Genes

Effect of Zoledronic Acid on Osteoblastic Differentiation of Mesenchymal Stem Cells and Epigenetic Changes

2010 ◽  
Vol 01 (01) ◽  
Author(s):  
Mehrdad Noruzinia ◽  
Majid Frashdousti Hagh ◽  
Yosef Mortazavi ◽  
Masood Soleimani ◽  
Saeed Kaviani
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Zoledronic Acid ◽  
Osteoblastic Differentiation ◽  
Epigenetic Changes

scholarly journals Epigenetic Signaling of Cancer Stem Cells During Inflammation

2021 ◽  
Vol 9 ◽  
Author(s):  
Zaoqu Liu ◽  
Yuqing Ren ◽  
Lingfang Meng ◽  
Lifeng Li ◽  
Richard Beatson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Signaling Pathways ◽  
Malignant Tumors ◽  
Epigenetic Mechanisms ◽  
Epigenetic Changes ◽  
Tumor Treatment ◽  
Smad Pathway ◽  
The Relationship

Malignant tumors pose a great challenge to human health, which has led to many studies increasingly elucidating the tumorigenic process. Cancer Stem Cells (CSCs) have profound impacts on tumorigenesis and development of drug resistance. Recently, there has been increased interest in the relationship between inflammation and CSCs but the mechanism underlying this relationship has not been fully elucidated. Inflammatory cytokines produced during chronic inflammation activate signaling pathways that regulate the generation of CSCs through epigenetic mechanisms. In this review, we focus on the effects of inflammation on cancer stem cells, particularly the role of signaling pathways such as NF-κB pathway, STAT3 pathway and Smad pathway involved in regulating epigenetic changes. We hope to provide a novel perspective for improving strategies for tumor treatment.

scholarly journals The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

2020 ◽  
Vol 21 (7) ◽  
pp. 2466 ◽  
Author(s):  
Yi-Chou Hou ◽  
Chien-Lin Lu ◽  
Cai-Mei Zheng ◽  
Wen-Chih Liu ◽  
Tzung-Hai Yen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Vitamin D ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Vascular Calcification ◽  
Osteoblastic Differentiation ◽  
Endothelial Progenitor

Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification.

scholarly journals Circ_0067680 expedites the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through miR-4429/CTNNB1/Wnt/β-catenin pathway

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yuansheng Huang ◽  
Su Wan ◽  
Min Yang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Regulatory Mechanism ◽  
Osteoblastic Differentiation ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Luciferase Reporter

Abstract Background Human bone marrow-derived mesenchymal stem cells (hBMSCs) are the primary source of osteoblasts in vivo. Emerging literatures have unveiled that circular RNAs (circRNAs) are actively drawn in the osteogenic differentiation of mesenchymal stem cells (MSCs). This research mainly illuminated the role of circ_0067680 as well as its regulatory mechanism in osteoblastic differentiation. Methods In this study, RT-qPCR was to measure the expression of circ_0067680. Functional assays were implemented to assess the role of circ_0067680 in osteogenic differentiation. Besides, RNA pull down, RIP and luciferase reporter assays were carried out to investigate the regulatory mechanism of circ_0067680. Results Circ_0067680, which derived from its host gene divergent protein kinase domain 2A (C3orf58), was up-regulated during osteogenic differentiation of hBMSCs. Besides, circ_0067680 deficiency impeded the osteoblastic differentiation of hBMSCs. Moreover, circ_0067680 served as a ceRNA via sequestering miR-4429 to regulate the expression of catenin beta 1 (CTNNB1), thereby activating the Wnt/β-catenin signaling pathway. Conclusion Circ_0067680 accelerated hBMSCs osteogenic differentiation by the miR-4429/CTNNB1/Wnt/β-catenin signaling, which might be used as a potential biomarker for osteoblastic differentiation. Graphic abstract

scholarly journals Role of the N-terminal peptide of amelogenin on osteoblastic differentiation of human mesenchymal stem cells

2014 ◽  
Vol 28 ◽  
pp. 1-10 ◽  
Author(s):  
R Olivares-Navarrete ◽  
◽  
K Vesper ◽  
SL Hyzy ◽  
A Almaguer-Flores ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Osteoblastic Differentiation
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