scholarly journals Spectroscopic studies of amphotericin B solubilized in nanoscale bilayer membranes

2006 ◽  
Vol 1758 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Peter L. Hargreaves ◽  
Thanh-Son Nguyen ◽  
Robert O. Ryan
Keyword(s):  
Amphotericin B ◽  
Spectroscopic Studies ◽  
Bilayer Membranes

Interaction of Amphotericin B and Nystatin with Phospholipid Bilayer Membranes: Effect of Cholesterol

1975 ◽  
Vol 53 (6) ◽  
pp. 1072-1079 ◽  
Author(s):  
Michael A. Singer
Keyword(s):  
Membrane Fluidity ◽  
Amphotericin B ◽  
Local Anesthetics ◽  
Cholesterol Content ◽  
Phospholipid Bilayer ◽  
High Cholesterol ◽  
Na Transport ◽  
Bilayer Membranes ◽  
Multilamellar Liposomes ◽  
Transmembrane Channels

Sodium-22 efflux was measured in multilamellar liposomes, exposed to one of the two polyene antibiotics amphotericin B or nystatin. Polyene mediated 22Na transport progressively rises with membrane sterol concentrations up to about 20 mol %, but falls with higher cholesterol concentrations. The polyene induced 22Na movement in cholesterol rich liposomes could be 'restored' by the addition of either dibucaine or propranolol (two local anesthetics) to the aqueous solution. These observations are interpreted in terms of the model of De Kruijff and Demel (Biochim. Biophys. Acta, 339, 57–70, 1974). In this model, nystatin and amphotericin B first complex with cholesterol and then these complexes aggregate to form transmembrane channels. It is here proposed that the aggregation of these complexes is inhibited by a high cholesterol content (decreased membrane fluidity) but that the two local anesthetics, by disrupting phospholipid–sterol interactions (increased membrane fluidity), can 'restore' this process of aggregation.

Aluminum binding to phosphatidylcholine lipid bilayer membranes: 27Al and 31P NMR spectroscopic studies

2004 ◽  
Vol 132 (1) ◽  
pp. 23-36 ◽  
Author(s):  
Neil MacKinnon ◽  
Kevin J. Crowell ◽  
Andrew K. Udit ◽  
Peter M. Macdonald
Keyword(s):  
Lipid Bilayer ◽  
31P Nmr ◽  
Spectroscopic Studies ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes

Spectroscopic studies of amphotericin B–Cu2+ complexes

BioMetals ◽  
2011 ◽  
Vol 24 (5) ◽  
pp. 915-922 ◽  
Author(s):  
Mariusz Gagoś ◽  
Grzegorz Czernel ◽  
Daniel M. Kamiński ◽  
Krzysztof Kostro
Keyword(s):  
Amphotericin B ◽  
Spectroscopic Studies
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