scholarly journals Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat

2016 ◽  
Vol 1862 (11) ◽  
pp. 2043-2053 ◽  
Author(s):  
Ariel D. Quiroga ◽  
María P. Ceballos ◽  
Juan P. Parody ◽  
Carla G. Comanzo ◽  
Florencia Lorenzetti ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Development ◽  
Early Stages

scholarly journals Vitamin K2 supplementation blocks the beneficial effects of IFN-α-2b administered on the early stages of liver cancer development in rats

Nutrition ◽  
2019 ◽  
Vol 59 ◽  
pp. 170-179
Author(s):  
Marina C. Vera ◽  
Florencia Lorenzetti ◽  
Alvaro Lucci ◽  
Carla G. Comanzo ◽  
María P. Ceballos ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Vitamin K2 ◽  
Cancer Development ◽  
Beneficial Effects ◽  
Early Stages

scholarly journals Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development

2017 ◽  
Vol 8 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Lichao Sun ◽  
Chunguang Guo ◽  
Joseph Burnett ◽  
Jian Pan ◽  
Zhihua Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Cancer ◽  
Clinical Significance ◽  
Cancer Development ◽  
Stem Cell Markers ◽  
Cell Markers

scholarly journals Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development

2012 ◽  
Vol 361 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Kristina M. Mueller ◽  
Madeleine Themanns ◽  
Katrin Friedbichler ◽  
Jan-Wilhelm Kornfeld ◽  
Harald Esterbauer ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Liver Cancer ◽  
Glucocorticoid Receptor ◽  
Body Growth ◽  
Cancer Development ◽  
Receptor Signaling

scholarly journals Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma

Genes ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 506 ◽  
Author(s):  
Edie-Rosmin Wu ◽  
Ying-Erh Chou ◽  
Yu-Fan Liu ◽  
Kuan-Chun Hsueh ◽  
Hsiang-Lin Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Gene Polymorphisms ◽  
Primary Liver Cancer ◽  
Common Type ◽  
Cancer Development ◽  
Inhibitory Effects ◽  
Non Coding Rna ◽  
H19 Gene ◽  
Long Non Coding Rna

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H19 can have both promotive and inhibitory effects on cancer development, revealing a dual role in tumorigenesis. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003–1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054–1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410–0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342–0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer.

scholarly journals Assessment of DNA methylation status in early stages of breast cancer development

2013 ◽  
Vol 108 (10) ◽  
pp. 2033-2038 ◽  
Author(s):  
A Q van Hoesel ◽  
Y Sato ◽  
D A Elashoff ◽  
R R Turner ◽  
A E Giuliano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Methylation Status ◽  
Cancer Development ◽  
Breast Cancer Development ◽  
Early Stages

256 DKK2 DELETION RESULTS IN ENHANCED LIVER CANCER DEVELOPMENT

2011 ◽  
Vol 54 ◽  
pp. S105-S106
Author(s):  
T. Maass ◽  
I. Sfakianakis ◽  
H. Westphal ◽  
P.R. Galle ◽  
A. Teufel
Keyword(s):  
Liver Cancer ◽  
Cancer Development

scholarly journals Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway

2015 ◽  
Vol 185 (4) ◽  
pp. 1045-1060 ◽  
Author(s):  
Le Thi Thanh Thuy ◽  
Yoshinari Matsumoto ◽  
Tuong Thi Van Thuy ◽  
Hoang Hai ◽  
Maito Suoh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Cancer ◽  
Cancer Development ◽  
Oxidative Stress Pathway ◽  
Stress Pathway
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