scholarly journals Assessment of DNA methylation status in early stages of breast cancer development

2013 ◽  
Vol 108 (10) ◽  
pp. 2033-2038 ◽  
Author(s):  
A Q van Hoesel ◽  
Y Sato ◽  
D A Elashoff ◽  
R R Turner ◽  
A E Giuliano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Methylation Status ◽  
Cancer Development ◽  
Breast Cancer Development ◽  
Early Stages

scholarly journals Effect of IFNα-2b on migrational ability of tumor cells on early stages of breast cancer development

2018 ◽  
Vol 29 ◽  
pp. iii24
Author(s):  
T. Herheliuk ◽  
O. Perepelytsina ◽  
L. Ostapchenko ◽  
M. Sydorenko
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Cancer Development ◽  
Breast Cancer Development ◽  
Early Stages

Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity

2017 ◽  
Vol 28 (4) ◽  
Author(s):  
Abed E. Zubidat ◽  
Abraham Haim
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Metabolic Disorders ◽  
Clock Genes ◽  
Experimental Studies ◽  
Circadian Disruption ◽  
Cancer Development ◽  
Artificial Light ◽  
Light At Night ◽  
Breast Cancer Development

AbstractBoth obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important role in the development of these syndromes. However, we still poorly understand the molecular mechanism underlying the association between circadian disruption and the modern health syndromes. One promising candidate is epigenetic modifications of various genes, including clock genes, circadian-related genes, oncogenes, and metabolic genes. DNA methylation is the most prominent epigenetic signaling tool for gene expression regulation induced by environmental exposures, such as artificial light-at-night (ALAN). In this review, we first provide an overview on the molecular feedback loops that generate the circadian regulation and how circadian disruption by ALAN can impose adverse impacts on public health, particularly metabolic disorders and breast cancer development. We then focus on the relation between ALAN-induced circadian disruption and both global DNA methylation and specific loci methylation in relation to obesity and breast cancer morbidities. DNA hypo-methylation and DNA hyper-methylation, are suggested as the most studied epigenetic tools for the activation and silencing of genes that regulate metabolic and monostatic responses. Finally, we discuss the potential clinical and therapeutic roles of MLT suppression and DNA methylation patterns as novel biomarkers for the early detection of metabolic disorders and breast cancer development.

Sign in / Sign up

Export Citation Format

Share Document