P0075 Overexpression of niemann-pick type C2 protein inhibits cell proliferation and liver cancer development via modulating the ERK1/2 pathway

2015 ◽  
Vol 51 ◽  
pp. e16
Author(s):  
Y.J. Liao ◽  
Y.H. Wang ◽  
C.Y. Liao ◽  
C.Y. Chen ◽  
Y.M. Chen
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Cancer Development ◽  
Niemann Pick

scholarly journals Underutilized Mexican Plants: Screening of Antioxidant and Antiproliferative Properties of Mexican Cactus Fruit Juices

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 368
Author(s):  
Elda M. Melchor Martínez ◽  
Luisaldo Sandate-Flores ◽  
José Rodríguez-Rodríguez ◽  
Magdalena Rostro-Alanis ◽  
Lizeth Parra-Arroyo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
In Vitro Assays ◽  
Total Phenolic ◽  
Liver Cancer Cell ◽  
Antiproliferative Activities

Cacti fruits are known to possess antioxidant and antiproliferative activities among other health benefits. The following paper evaluated the antioxidant capacity and bioactivity of five clarified juices from different cacti fruits (Stenocereus spp., Opuntia spp. and M. geomettizans) on four cancer cell lines as well as one normal cell line. Their antioxidant compositions were measured by three different protocols. Their phenolic compositions were quantified through high performance liquid chromatography and the percentages of cell proliferation of fibroblasts as well as breast, prostate, colorectal, and liver cancer cell lines were evaluated though in vitro assays. The results were further processed by principal component analysis. The clarified juice from M. geomettizans fruit showed the highest concentration of total phenolic compounds and induced cell death in liver and colorectal cancer cells lines as well as fibroblasts. The clarified juice extracted from yellow Opuntia ficus-indica fruit displayed antioxidant activity as well as a selective cytotoxic effect on a liver cancer cell line with no toxic effect on fibroblasts. In conclusion, the work supplies evidence on the antioxidant and antiproliferative activities that cacti juices possess, presenting potential as cancer cell proliferation preventing agents.

Effects of AFP-activated PI3K/Akt signaling pathway on cell proliferation of liver cancer

Tumor Biology ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 4095-4099 ◽  
Author(s):  
Lu Zheng ◽  
Wei Gong ◽  
Ping Liang ◽  
XiaoBing Huang ◽  
Nan You ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway

scholarly journals PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation

2013 ◽  
Vol 185 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Roberto Gedaly ◽  
Roberto Galuppo ◽  
Yolanda Musgrave ◽  
Paul Angulo ◽  
Jonathan Hundley ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Liver Cancer ◽  
Cancer Stem Cell ◽  
Stem Cell Proliferation ◽  
Liver Cancer Stem Cell

scholarly journals Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat

2016 ◽  
Vol 1862 (11) ◽  
pp. 2043-2053 ◽  
Author(s):  
Ariel D. Quiroga ◽  
María P. Ceballos ◽  
Juan P. Parody ◽  
Carla G. Comanzo ◽  
Florencia Lorenzetti ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Development ◽  
Early Stages

scholarly journals Kaempferol inhibits proliferation, migration, and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21

2018 ◽  
Vol 32 ◽  
pp. 205873841881434 ◽  
Author(s):  
Genglong Zhu ◽  
Xialei Liu ◽  
Haijing Li ◽  
Yang Yan ◽  
Xiaopeng Hong ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Signaling Pathway ◽  
Hepg2 Cell ◽  
Cell Apoptosis ◽  
Hepg2 Cells ◽  
Mtor Signaling ◽  
Brdu Incorporation ◽  
Migration And Invasion ◽  
Mtor Signaling Pathway

Liver cancer is one of the most common and lethal cancers in human digestive system, which kills more than half a million people every year worldwide. This study aimed to investigate the effects of kaempferol, a flavonoid compound isolated from vegetables and fruits, on hepatic cancer HepG2 cell proliferation, migration, invasion, and apoptosis, as well as microRNA-21 (miR-21) expression. Cell viability was detected using cell counting kit-8 (CCK-8) assay. Cell proliferation was measured using 5-bromo-2′-deoxyuridine (BrdU) incorporation assay. Cell apoptosis was assessed using Guava Nexin assay. Cell migration and invasion were determined using two-chamber migration (invasion) assay. Cell transfection was used to change the expression of miR-21. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to analyze the expressions of miR-21 and phosphatase and tensin homologue (PTEN). Expression of key proteins involved in proliferation, apoptosis, migration, invasion, and phosphatidylinositol 3-kinase/protein kinase 3/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway were evaluated using western blotting. Results showed that kaempferol significantly inhibited HepG2 cell proliferation, migration, and invasion, and induced cell apoptosis. Kaempferol remarkably reduce the expression of miR-21 in HepG2 cells. Overexpression of miR-21 obviously reversed the effects of kaempferol on HepG2 cell proliferation, migration, invasion, and apoptosis. Moreover, miR-21 negatively regulated the expression of PTEN in HepG2 cells. Kaempferol enhanced the expression of PTEN and inactivated PI3K/AKT/mTOR signaling pathway in HepG2 cells. In conclusion, kaempferol inhibited proliferation, migration, and invasion of HepG2 cells by down-regulating miR-21 and up-regulating PTEN, as well as inactivating PI3K/AKT/mTOR signaling pathway.

scholarly journals Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development

2017 ◽  
Vol 8 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Lichao Sun ◽  
Chunguang Guo ◽  
Joseph Burnett ◽  
Jian Pan ◽  
Zhihua Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Cancer ◽  
Clinical Significance ◽  
Cancer Development ◽  
Stem Cell Markers ◽  
Cell Markers

scholarly journals MicroRNA-214 targets Wnt3a to suppress liver cancer cell proliferation

2017 ◽  
Vol 16 (5) ◽  
pp. 6920-6927 ◽  
Author(s):  
Yang Yang ◽  
Zhenghao Zhao ◽  
Ni Hou ◽  
Yulong Li ◽  
Xiaofei Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Liver Cancer Cell
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