Facilitating drug release in mesoporous silica coated upconversion nanoparticles by photoacid assistance upon near-infrared irradiation

2020 ◽  
Vol 31 (9) ◽  
pp. 3860-3866
Author(s):  
Renlu Han ◽  
Sheng Wu ◽  
Keqi Tang ◽  
Yafei Hou
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Upconversion Nanoparticles ◽  
Infrared Irradiation

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

Near-Infrared-Light-Induced Fast Drug Release Platform: Mesoporous Silica-Coated Gold Nanoframes for Thermochemotherapy

2016 ◽  
Vol 33 (6) ◽  
pp. 316-322 ◽  
Author(s):  
Haosha Tang ◽  
Liangqing Yao ◽  
Jianping Yang ◽  
Wei Li ◽  
Zhaogang Teng ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

Transferrin-coated magnetic upconversion nanoparticles for efficient photodynamic therapy with near-infrared irradiation and luminescence bioimaging

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11214-11221 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Jian-Feng Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Force ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Infrared Irradiation ◽  
Near Infrared Light

A novel platform based on transferrin coated magnetic upconversion nanoparticles was developed for near-infrared light induced imaging and photodynamic therapy with enhanced efficiency by magnetic force.

scholarly journals Mesoporous Silica Encapsulated Iron Oxide-Silver Heterodimeric Nanoparticles and Their Applications in Multi-Responsive Drug Release

2021 ◽  
Author(s):  
Xiaoting Sun ◽  
Xiaohui Zhang ◽  
Huazhe Yang ◽  
Xiaohong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Combined Therapy ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Ph Response ◽  
Growth Method

Abstract Background Metal based nanomaterials play essential roles in the fields of cancer diagnosis and therapy, drug delivery and exploration. As a novel kind of metal nanocomposites, magnetic-plasmonic nanohybrids are promising candidates in combined therapy. However, few studies have demonstrated the multi-responsive drug delivery properties of the nanohybrids. In this work, novel Fe3O4-Ag heterodimer nanoparticles coated with mesoporous SiO2 were prepared for multi-responsive drug release applications. Results Seed growth method was employed to form the heterodimer particles, and a layer of mesoporous silica was coated on the particle to improve the biocompatibility of metal nanoparticles, which also acted as drug loading and release component. Characterized via infrared spectroscopy, X-Ray diffraction and transmission electron microscopy, the particles were confirmed to appear a Janus like structure with Fe3O4 and Ag hemispheres encapsulating in silica. Doxorubicin hydrochloride (DOX) was loaded on the surface of the particles for drug delivery. The drug loading efficiency, release performance and the apoptosis action of the particles on MCF-7 cells were investigated in vitro. The results showed that DOX was successfully loaded on the particles with encapsulation efficiency of 88.3% and drug loading of 30.6%. And the release amount after 48 h increased from 10.05 ± 0.19% to 68.53 ± 8.20% as the environment was tuned to acidic, indicating an obvious pH response of the particles. Simultaneously, due to the photothermal effect of Ag hemispheres, the particles had exhibited an enhanced drug release stimulated by 808 nm near infrared (NIR) irradiation. And the results of apoptosis assay were in accord with the drug release profiles. Besides, the particles could well respond to an external magnetic field, which is beneficial to particle location or recovery. Conclusion The as-prepared particles exhibit good magnetic and photothermal properties originating from Fe3O4 and Ag hemispheres respectively, which are desired features in magnetic hyperthermia and photothermal therapy. The particles also possess pH and NIR light responsive drug release properties, enabling triggered and targeted drug delivery.

MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O2 self-sufficient photodynamic therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14654-14667 ◽  
Author(s):  
Binbin Ding ◽  
Shuai Shao ◽  
Haihua Xiao ◽  
Chunqiang Sun ◽  
Xuechao Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Large Pore

Upconversion hybrid theranostic nanoplatform for near-infrared light-induced and O2 self-sufficient photodynamic therapy.

Spatially Confined Fabrication of Core–Shell Gold Nanocages@Mesoporous Silica for Near-Infrared Controlled Photothermal Drug Release

2013 ◽  
Vol 25 (15) ◽  
pp. 3030-3037 ◽  
Author(s):  
Jianping Yang ◽  
Dengke Shen ◽  
Lei Zhou ◽  
Wei Li ◽  
Xiaomin Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Core Shell ◽  
Gold Nanocages
Sign in / Sign up

Export Citation Format

Share Document