Spatially Confined Fabrication of Core–Shell Gold Nanocages@Mesoporous Silica for Near-Infrared Controlled Photothermal Drug Release

2013 ◽  
Vol 25 (15) ◽  
pp. 3030-3037 ◽  
Author(s):  
Jianping Yang ◽  
Dengke Shen ◽  
Lei Zhou ◽  
Wei Li ◽  
Xiaomin Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Core Shell ◽  
Gold Nanocages

Near-Infrared-Light-Induced Fast Drug Release Platform: Mesoporous Silica-Coated Gold Nanoframes for Thermochemotherapy

2016 ◽  
Vol 33 (6) ◽  
pp. 316-322 ◽  
Author(s):  
Haosha Tang ◽  
Liangqing Yao ◽  
Jianping Yang ◽  
Wei Li ◽  
Zhaogang Teng ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

Fe3O4@mSiO2 core–shell nanocomposite capped with disulfide gatekeepers for enzyme-sensitive controlled release of anti-cancer drugs

2015 ◽  
Vol 3 (6) ◽  
pp. 1010-1019 ◽  
Author(s):  
Chunyu Yang ◽  
Wei Guo ◽  
Liru Cui ◽  
Na An ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Shell ◽  
Core Shell ◽  
Passive Targeting ◽  
Anti Cancer ◽  
Multifunctional Nanocarriers ◽  
Nanoparticle Core

Multifunctional nanocarriers based on the magnetic Fe3O4 nanoparticle core and bis-(3-carboxy-4-hydroxy phenyl) disulfide modified mesoporous silica shell were synthesized for cancer treatment through passive targeting and enzyme-sensitive drug release.

scholarly journals Mesoporous Silica Encapsulated Iron Oxide-Silver Heterodimeric Nanoparticles and Their Applications in Multi-Responsive Drug Release

2021 ◽  
Author(s):  
Xiaoting Sun ◽  
Xiaohui Zhang ◽  
Huazhe Yang ◽  
Xiaohong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Combined Therapy ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Ph Response ◽  
Growth Method

Abstract Background Metal based nanomaterials play essential roles in the fields of cancer diagnosis and therapy, drug delivery and exploration. As a novel kind of metal nanocomposites, magnetic-plasmonic nanohybrids are promising candidates in combined therapy. However, few studies have demonstrated the multi-responsive drug delivery properties of the nanohybrids. In this work, novel Fe3O4-Ag heterodimer nanoparticles coated with mesoporous SiO2 were prepared for multi-responsive drug release applications. Results Seed growth method was employed to form the heterodimer particles, and a layer of mesoporous silica was coated on the particle to improve the biocompatibility of metal nanoparticles, which also acted as drug loading and release component. Characterized via infrared spectroscopy, X-Ray diffraction and transmission electron microscopy, the particles were confirmed to appear a Janus like structure with Fe3O4 and Ag hemispheres encapsulating in silica. Doxorubicin hydrochloride (DOX) was loaded on the surface of the particles for drug delivery. The drug loading efficiency, release performance and the apoptosis action of the particles on MCF-7 cells were investigated in vitro. The results showed that DOX was successfully loaded on the particles with encapsulation efficiency of 88.3% and drug loading of 30.6%. And the release amount after 48 h increased from 10.05 ± 0.19% to 68.53 ± 8.20% as the environment was tuned to acidic, indicating an obvious pH response of the particles. Simultaneously, due to the photothermal effect of Ag hemispheres, the particles had exhibited an enhanced drug release stimulated by 808 nm near infrared (NIR) irradiation. And the results of apoptosis assay were in accord with the drug release profiles. Besides, the particles could well respond to an external magnetic field, which is beneficial to particle location or recovery. Conclusion The as-prepared particles exhibit good magnetic and photothermal properties originating from Fe3O4 and Ag hemispheres respectively, which are desired features in magnetic hyperthermia and photothermal therapy. The particles also possess pH and NIR light responsive drug release properties, enabling triggered and targeted drug delivery.

Novel preparation and near-infrared photoluminescence of uniform core-shell silver sulfide nanoparticle@mesoporous silica nanospheres

2012 ◽  
Vol 22 (15) ◽  
pp. 7274 ◽  
Author(s):  
Lu Han ◽  
Yingying Lv ◽  
Abdullah M. Asiri ◽  
Abdulrahman O. Al-Youbi ◽  
Bo Tu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Near Infrared ◽  
Silver Sulfide ◽  
Core Shell ◽  
Silica Nanospheres ◽  
Mesoporous Silica Nanospheres
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