Anti-bacterial efficacy via drug-delivery system from layer-by-layer coating for percutaneous dental implant components

2019 ◽  
Vol 488 ◽  
pp. 194-204 ◽  
Author(s):  
Erica D. de Avila ◽  
Antonio G.B. Castro ◽  
Oya Tagit ◽  
Bastiaan P. Krom ◽  
Dennis Löwik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Dental Implant ◽  
Delivery System ◽  
Layer By Layer ◽  
Layer Coating

Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56323-56331 ◽  
Author(s):  
Xiaorui Li ◽  
Pengcheng Du ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Methacrylic Acid ◽  
Polyelectrolyte Complex ◽  
Core Shell ◽  
Layer By Layer ◽  
Structural Effects

The structure of core–shell nanogels@polyelectrolyte complex microspheres was optimized as a drug delivery system for controlled release.

scholarly journals The Metabolic Response of Various Cell Lines to Microtubule-Driven Uptake of Lipid- and Polymer-Coated Layer-by-Layer Microcarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1441
Author(s):  
Claudia Claus ◽  
Robert Fritz ◽  
Erik Schilling ◽  
Uta Reibetanz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayer ◽  
Cell Lines ◽  
Delivery System ◽  
Cellular Metabolism ◽  
Vero Cells ◽  
Layer By Layer ◽  
The Impact ◽  
Lipid Structures

Lipid structures, such as liposomes or micelles, are of high interest as an approach to support the transport and delivery of active agents as a drug delivery system. However, there are many open questions regarding their uptake and impact on cellular metabolism. In this study, lipid structures were assembled as a supported lipid bilayer on top of biopolymer-coated microcarriers based on the Layer-by-Layer assembly strategy. The functionalized microcarriers were then applied to various human and animal cell lines in addition to primary human macrophages (MΦ). Here, their influence on cellular metabolism and their intracellular localization were detected by extracellular flux analysis and immunofluorescence analysis, respectively. The impact of microcarriers on metabolic parameters was in most cell types rather low. However, lipid bilayer-supported microcarriers induced a decrease in oxygen consumption rate (OCR, indicative for mitochondrial respiration) and extracellular acidification rate (ECAR, indicative for glycolysis) in Vero cells. Additionally, in Vero cells lipid bilayer microcarriers showed a more pronounced association with microtubule filaments than polymer-coated microcarrier. Furthermore, they localized to a perinuclear region and induced nuclei with some deformations at a higher rate than unfunctionalized carriers. This association was reduced through the application of the microtubule polymerization inhibitor nocodazole. Thus, the effect of respective lipid structures as a drug delivery system on cells has to be considered in the context of the respective target cell, but in general can be regarded as rather low.

Layer-by-Layer Engineered Microbicide Drug Delivery System Targeting HIV-1 gp120: Physicochemical and Biological Properties

2017 ◽  
Vol 14 (10) ◽  
pp. 3512-3527 ◽  
Author(s):  
Fohona S. Coulibaly ◽  
Miezan J. M. Ezoulin ◽  
Sudhaunshu S. Purohit ◽  
Navid J. Ayon ◽  
Nathan A. Oyler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Properties ◽  
Layer By Layer ◽  
Physicochemical And Biological Properties ◽  
Hiv 1

Controlled Drug Delivery System Based on Magnetic Hollow Spheres/Polyelectrolyte Multilayer Core–Shell Structure

2006 ◽  
Vol 6 (9) ◽  
pp. 3210-3214 ◽  
Author(s):  
YanQi Zhang ◽  
LinLin Li ◽  
Fangqiong Tang ◽  
Jun Ren
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hollow Spheres ◽  
Hollow Structure ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Layer By Layer ◽  
Controlled Drug Delivery System ◽  
Model Drug

A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core–shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core–shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.

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