scholarly journals Cellular interaction of a layer-by-layer based drug delivery system depending on material properties and cell types

2018 ◽  
Vol Volume 13 ◽  
pp. 2079-2091 ◽  
Author(s):  
Mandy Brueckner ◽  
Steffen Jankuhn ◽  
Eva-Maria Jülke ◽  
Uta Reibetanz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Material Properties ◽  
Cell Types ◽  
Cellular Interaction ◽  
Layer By Layer

Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56323-56331 ◽  
Author(s):  
Xiaorui Li ◽  
Pengcheng Du ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Methacrylic Acid ◽  
Polyelectrolyte Complex ◽  
Core Shell ◽  
Layer By Layer ◽  
Structural Effects

The structure of core–shell nanogels@polyelectrolyte complex microspheres was optimized as a drug delivery system for controlled release.

scholarly journals The Metabolic Response of Various Cell Lines to Microtubule-Driven Uptake of Lipid- and Polymer-Coated Layer-by-Layer Microcarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1441
Author(s):  
Claudia Claus ◽  
Robert Fritz ◽  
Erik Schilling ◽  
Uta Reibetanz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayer ◽  
Cell Lines ◽  
Delivery System ◽  
Cellular Metabolism ◽  
Vero Cells ◽  
Layer By Layer ◽  
The Impact ◽  
Lipid Structures

Lipid structures, such as liposomes or micelles, are of high interest as an approach to support the transport and delivery of active agents as a drug delivery system. However, there are many open questions regarding their uptake and impact on cellular metabolism. In this study, lipid structures were assembled as a supported lipid bilayer on top of biopolymer-coated microcarriers based on the Layer-by-Layer assembly strategy. The functionalized microcarriers were then applied to various human and animal cell lines in addition to primary human macrophages (MΦ). Here, their influence on cellular metabolism and their intracellular localization were detected by extracellular flux analysis and immunofluorescence analysis, respectively. The impact of microcarriers on metabolic parameters was in most cell types rather low. However, lipid bilayer-supported microcarriers induced a decrease in oxygen consumption rate (OCR, indicative for mitochondrial respiration) and extracellular acidification rate (ECAR, indicative for glycolysis) in Vero cells. Additionally, in Vero cells lipid bilayer microcarriers showed a more pronounced association with microtubule filaments than polymer-coated microcarrier. Furthermore, they localized to a perinuclear region and induced nuclei with some deformations at a higher rate than unfunctionalized carriers. This association was reduced through the application of the microtubule polymerization inhibitor nocodazole. Thus, the effect of respective lipid structures as a drug delivery system on cells has to be considered in the context of the respective target cell, but in general can be regarded as rather low.

Techniques and Applications of Animal- and Plant-Derived Exosome-Based Drug Delivery System

2020 ◽  
Vol 16 (11) ◽  
pp. 1543-1569
Author(s):  
Fulong Man ◽  
Junfeng Wang ◽  
Rong Lu
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Cell Types ◽  
Extracellular Vesicle ◽  
Cellular Communication ◽  
Different Cell Types

Exosomes are a kind of extracellular vesicle, has a particle size of 50–150 nm. Exosomes derived from different cell types are thought to participate in the regulation of cellular communication. On account of the ability of exosomes to deliver various cargos to a corresponding target site, they are often used to deliver therapeutic cargos for treatment. This review summarizes the origins and composition of exosomes, and provides a detailed overview of the current methods for exosome isolation and drug loading as well as the application of exosomes to drug delivery systems (DDSs) to provide practical suggestions for exosome studies. Moreover, this review also highlights the research progresses on plant-derived exosomes in determining their commonalities with and distinctions from animal-derived exosomes, and the advantages and challenges faced by plant-derived exosomes as drug delivery carriers are also discussed to contribute to the further application of plant-derived exosomes.

Layer-by-Layer Engineered Microbicide Drug Delivery System Targeting HIV-1 gp120: Physicochemical and Biological Properties

2017 ◽  
Vol 14 (10) ◽  
pp. 3512-3527 ◽  
Author(s):  
Fohona S. Coulibaly ◽  
Miezan J. M. Ezoulin ◽  
Sudhaunshu S. Purohit ◽  
Navid J. Ayon ◽  
Nathan A. Oyler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Properties ◽  
Layer By Layer ◽  
Physicochemical And Biological Properties ◽  
Hiv 1

Controlled Drug Delivery System Based on Magnetic Hollow Spheres/Polyelectrolyte Multilayer Core–Shell Structure

2006 ◽  
Vol 6 (9) ◽  
pp. 3210-3214 ◽  
Author(s):  
YanQi Zhang ◽  
LinLin Li ◽  
Fangqiong Tang ◽  
Jun Ren
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hollow Spheres ◽  
Hollow Structure ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Layer By Layer ◽  
Controlled Drug Delivery System ◽  
Model Drug

A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core–shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core–shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.

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