Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56323-56331 ◽  
Author(s):  
Xiaorui Li ◽  
Pengcheng Du ◽  
Peng Liu

The structure of core–shell nanogels@polyelectrolyte complex microspheres was optimized as a drug delivery system for controlled release.

2006 ◽  
Vol 6 (9) ◽  
pp. 3210-3214 ◽  
Author(s):  
YanQi Zhang ◽  
LinLin Li ◽  
Fangqiong Tang ◽  
Jun Ren

A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core–shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core–shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.


Author(s):  
Maryam Bakhshizadeh ◽  
Ameneh Sazgarnia ◽  
Mahmoud Seifi ◽  
Farzin Hadizadeh ◽  
Ghadir Rajabzadeh ◽  
...  

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.


RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.


Author(s):  
Mohammad Javad Khodabakhshi ◽  
Homayon Ahmad Panahi ◽  
Elaheh Konoz ◽  
Alireza Feizbakhsh ◽  
Salimeh Kimiagar

2018 ◽  
Vol 553 (1-2) ◽  
pp. 169-185 ◽  
Author(s):  
Primiano Pio Di Mauro ◽  
Anna Cascante ◽  
Pau Brugada Vilà ◽  
Vanessa Gómez-Vallejo ◽  
Jordi Llop ◽  
...  

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