WITHDRAWN: Critical role of dopamine D1 receptors in nucleus accumbens shell in flavor preference conditioning by intragastric glucose infusion

Appetite ◽  
2006 ◽  
Author(s):  
A. Sclafani ◽  
K. Touzani ◽  
R.J. Bodnar
Keyword(s):  
Nucleus Accumbens ◽  
Critical Role ◽  
Glucose Infusion ◽  
D1 Receptors ◽  
Flavor Preference ◽  
Nucleus Accumbens Shell ◽  
Dopamine D1 Receptors ◽  
Flavor Preference Conditioning ◽  
Preference Conditioning

Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition

2005 ◽  
Vol 184 (3-4) ◽  
pp. 447-455 ◽  
Author(s):  
Liliana Spina ◽  
Sandro Fenu ◽  
Rosanna Longoni ◽  
Emilia Rivas ◽  
Gaetano Di Chiara
Keyword(s):  
Nucleus Accumbens ◽  
Place Preference ◽  
D1 Receptors ◽  
Single Trial ◽  
Nucleus Accumbens Shell ◽  
Dopamine D1 Receptors

Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine

2013 ◽  
Vol 16 (8) ◽  
pp. 1767-1780 ◽  
Author(s):  
Li-li Sun ◽  
Yan Zhang ◽  
Jian-feng Liu ◽  
Jun Wang ◽  
Wei-li Zhu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopaminergic System ◽  
Critical Role ◽  
Locomotor Sensitization ◽  
Nucleus Accumbens Shell ◽  
Erk Phosphorylation ◽  
Melanin Concentrating Hormone ◽  
Erk Activity ◽  
The Brain

Abstract Melanin-concentrating hormone (MCH) is a neuropeptide and its receptor is extensively expressed throughout the brain. MCH has been suggested to regulate the rewarding and reinforcing effects of psychostimulants by potentiating the dopaminergic system within the midbrain. Moreover, MCH and its receptor can regulate ERK activity. The present study investigated the role of MCH in the nucleus accumbens (NAc) in rats behaviourally sensitized to methamphetamine (Meth). We found that the development of Meth-induced locomotor sensitization was attenuated by MCH infused into the NAc shell but not core. Moreover, the elevation of ERK phosphorylation in the NAc shell induced by Meth was inhibited by locally infused MCH. Infusion of the MCH receptor 1 (MCHR1) antagonist SNAP 94847 into the NAc shell but not core augmented the initiation of locomotor sensitization and amplitude of elevated phosphorylated ERK levels induced by Meth. The expression of Meth-induced locomotor sensitization and ERK alterations after 1 wk withdrawal were not affected by either MCH or SNAP 94847 infused into the NAc shell or core. These results indicate that MCH in the NAc shell plays a critical role in the development but not expression of Meth-induced locomotor sensitization in rats, which might be mediated by the ERK signalling pathway. Our study suggests that MCH might be a potential target for the treatment of Meth addiction.

Sign in / Sign up

Export Citation Format

Share Document