scholarly journals Role of Dopamine D1 Receptors in the Activation of Nucleus Accumbens Extracellular Signal-Regulated Kinase (ERK) by Cocaine-Paired Contextual Cues

2010 ◽  
Vol 36 (2) ◽  
pp. 434-444 ◽  
Author(s):  
Ashley N Fricks-Gleason ◽  
John F Marshall
Keyword(s):  
Nucleus Accumbens ◽  
D1 Receptors ◽  
Contextual Cues ◽  
Dopamine D1 Receptors ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition

2005 ◽  
Vol 184 (3-4) ◽  
pp. 447-455 ◽  
Author(s):  
Liliana Spina ◽  
Sandro Fenu ◽  
Rosanna Longoni ◽  
Emilia Rivas ◽  
Gaetano Di Chiara
Keyword(s):  
Nucleus Accumbens ◽  
Place Preference ◽  
D1 Receptors ◽  
Single Trial ◽  
Nucleus Accumbens Shell ◽  
Dopamine D1 Receptors

ERK5 and its role in tumour development

2012 ◽  
Vol 40 (1) ◽  
pp. 251-256 ◽  
Author(s):  
Pamela A. Lochhead ◽  
Rebecca Gilley ◽  
Simon J. Cook
Keyword(s):  
Mitogen Activated Protein Kinase ◽  
Invasion And Migration ◽  
Extracellular Signal Regulated Kinase ◽  
Protein Levels ◽  
Extracellular Signal ◽  
Mapk Signalling ◽  
Mitogen Activated Protein ◽  
Tumour Cell Invasion ◽  
And Migration

The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the ‘hallmarks of cancer’ as a framework and consider how this pathway is deregulated. As well as playing a key role in endothelial cell survival and tubular morphogenesis during tumour neovascularization, ERK5 is also emerging as a regulator of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145. Together, these finding underscore the case for further investigation into understanding the role of ERK5 in cancer.

scholarly journals Possible role of dopamine D1 receptors in schizophrenia

1997 ◽  
Vol 2 (4) ◽  
pp. 291-292 ◽  
Author(s):  
Y Okuba ◽  
T Suhara ◽  
Y Sudo ◽  
M Toru
Keyword(s):  
D1 Receptors ◽  
Dopamine D1 Receptors

cAMP and Extracellular Signal-Regulated Kinase Signaling in Response to d-Amphetamine and Methylphenidate in the Prefrontal Cortex in Vivo: Role of β1-Adrenoceptors

2005 ◽  
Vol 68 (2) ◽  
pp. 421-429 ◽  
Author(s):  
Vincent Pascoli ◽  
Emmanuel Valjent ◽  
Anne-Gaëlle Corbillé ◽  
Jean-Christophe Corvol ◽  
Jean-Pol Tassin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Kinase Signaling ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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