Bioreducible and traceable Ru(III) prodrug-loaded mesoporous silica nanoparticles for sequentially targeted nonsmall cell lung cancer chemotherapy

2020 ◽  
Vol 19 ◽  
pp. 100558 ◽  
Author(s):  
Fangman Chen ◽  
Fan Zhang ◽  
Dan Shao ◽  
Weibin Zhang ◽  
Liqin Zheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Chemotherapy ◽  
Cell Lung Cancer ◽  
Mesoporous Silica Nanoparticles ◽  
Nonsmall Cell Lung Cancer

Combinatorial delivery of targeted mesoporous silica nanoparticles for lung cancer therapy

2016 ◽  
Author(s):  
Deniz Ali Bölükbas ◽  
Stefan Datz ◽  
Charlotte Meyer-Schwickerath ◽  
Malamati Vreka ◽  
Sabine van Rijt ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Lung Cancer Therapy

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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