Augmented Anticancer Efficacy by si-RNA Complexed Drug-Loaded Mesoporous Silica Nanoparticles in Lung Cancer Therapy

2018 ◽  
Vol 1 (2) ◽  
pp. 730-740 ◽  
Author(s):  
Fahima Dilnawaz ◽  
Sanjeeb K Sahoo
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Anticancer Efficacy ◽  
Lung Cancer Therapy ◽  
Si Rna

Combinatorial delivery of targeted mesoporous silica nanoparticles for lung cancer therapy

2016 ◽  
Author(s):  
Deniz Ali Bölükbas ◽  
Stefan Datz ◽  
Charlotte Meyer-Schwickerath ◽  
Malamati Vreka ◽  
Sabine van Rijt ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Lung Cancer Therapy

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

NIR-absorbing dye functionalized hollow mesoporous silica nanoparticles for combined photothermal–chemotherapy

2017 ◽  
Vol 53 (88) ◽  
pp. 12032-12035 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Qiuyu Qu ◽  
Xiang Cao ◽  
Yanli Zhao
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Anticancer Efficacy ◽  
Hollow Mesoporous Silica ◽  
Multifunctional Nanocarriers

Multifunctional nanocarriers consisting of hollow mesoporous silica nanoparticles loaded with doxorubicin and then capped by a complex between disulfide linked β-cyclodextrin and adamantane functionalized indocyanine dye are developed for improved anticancer efficacy through combined photothermal–chemotherapy.

scholarly journals Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy

2020 ◽  
Vol 12 (4) ◽  
pp. 4308-4322 ◽  
Author(s):  
Yazhe Wang ◽  
Ying Xie ◽  
Kameron V. Kilchrist ◽  
Jing Li ◽  
Craig L. Duvall ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Combination Cancer Therapy
Sign in / Sign up

Export Citation Format

Share Document