Doxorubicin Hydrochloride-Loaded Mesoporous Silica Nanoparticles Inhibit Non-Small Cell Lung Cancer Metastasis by Suppressing VEGF-Mediated Angiogenesis

2016 ◽  
Vol 12 (11) ◽  
pp. 1975-1986 ◽  
Author(s):  
Min Zhang ◽  
Li Jiang
Keyword(s):  
Lung Cancer ◽  
Mesoporous Silica ◽  
Small Cell Lung Cancer ◽  
Silica Nanoparticles ◽  
Cancer Metastasis ◽  
Mesoporous Silica Nanoparticles ◽  
Small Cell ◽  
Doxorubicin Hydrochloride ◽  
Small Cell Lung ◽  
Lung Cancer Metastasis

Nm23-H1 inhibits hypoxia induced epithelial-mesenchymal transition and stemness in non-small cell lung cancer cells

2019 ◽  
Vol 400 (6) ◽  
pp. 765-776 ◽  
Author(s):  
Cun-en Wu ◽  
Yu-wen Zhuang ◽  
Jin-yong Zhou ◽  
Shen-lin Liu ◽  
Xi Zou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Small Cell Lung ◽  
Mesenchymal Transition ◽  
Lung Cancer Metastasis ◽  
Allelic Deletion

Abstract The Nm23 gene has been acknowledged to play a crucial role in lung cancer metastasis inhibitory cascades controlled by multiple factors. Low expression or allelic deletion of nm23-H1 is strongly linked to widespread metastasis and poor differentiation of non-small cell lung cancer (NSCLC). In this study, nm23-H1 was down regulated in epithelial-mesenchymal transition (EMT) and stemness enhancement under cobalt chloride (CoCl2)-induced hypoxia in NSCLC cells. Moreover, knocking down of nm23-H1 by shRNA apparently promoted hypoxia induced EMT and stemness, which was entirely suppressed via over expression of nm23-H1. Mechanistically, the Wnt/β-catenin signaling pathway was found to participate in the nm23-H1-mediated process. Besides, XAV939 prohibited cell EMT and stemness which could be impaired by knocking down of nm23-H1, while stable transfection of nm23-H1 attenuated hypoxia phonotype induced by lithium chloride (LiCl). Generally, our experiment provided evidence that nm23-H1 can reverse hypoxia induced EMT and stemness through the inhibition of the Wnt/β-catenin pathway, which may furnish a deeper perspective into the better treatment or prognosis for NSCLC.

scholarly journals Cyclophilin A promotes non-small cell lung cancer metastasis via p38 MAPK

2017 ◽  
Vol 9 (1) ◽  
pp. 120-128 ◽  
Author(s):  
Yinan Guo ◽  
Mei Jiang ◽  
Xiaoting Zhao ◽  
Meng Gu ◽  
Ziyu Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
P38 Mapk ◽  
Cell Lung Cancer ◽  
Cancer Metastasis ◽  
Cyclophilin A ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Metastasis

scholarly journals Integrin αvβ5 as a biomarker for the assessment of non‐small cell lung cancer metastasis and overall survival

2014 ◽  
Vol 9 (4) ◽  
pp. 457-467 ◽  
Author(s):  
Sally Yan Bai ◽  
Nuo Xu ◽  
Cuicui Chen ◽  
Yuan‐lin Song ◽  
Jie Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Metastasis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Metastasis
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