Modifying graphene oxide with short peptide via click chemistry for biomedical applications

2016 ◽  
Vol 5 ◽  
pp. 111-117 ◽  
Author(s):  
Lin Shi ◽  
Lin Wang ◽  
Junjian Chen ◽  
Jiongrun Chen ◽  
Li Ren ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Click Chemistry ◽  
Biomedical Applications ◽  
Short Peptide

scholarly journals A New Approach to Obtaining Nano-Sized Graphene Oxide for Biomedical Applications

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1327
Author(s):  
Paulina Bolibok ◽  
Bartosz Szymczak ◽  
Katarzyna Roszek ◽  
Artur P. Terzyk ◽  
Marek Wiśniewski
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Effective Concentration ◽  
New Approach ◽  
Spectral Changes ◽  
Dimethyl Sulfoxide Solution ◽  
Aggregation Processes ◽  
Initial Oxygen ◽  
Half Maximal Effective Concentration ◽  
Nano Size

Graphene oxide (GO) is one of the most exciting and widely used materials. A new method of nanographene oxide (n-GO) formation is presented. The described unique sequence of ultrasonication in dimethyl sulfoxide solution allows us to obtain different sizes of n-GO sheets by controlling the timing of the cutting and re-aggregation processes. The obtained n-GO exhibits only minor spectral changes, mainly due to the formation of S-containing surface groups; thus, it can be concluded that the material is not reduced during the process. Maintaining the initial oxygen functionalities together with the required nano-size (down to 200 nm) and high homogeneity are beneficial for extensive applications of n-GO. Moreover, we prove that the obtained material is evidently biocompatible. The calculated half-maximal effective concentration (EC50) increases by 5-fold, i.e., from 50 to 250 µg/mL, when GO is converted to n-GO. As a consequence, the new n-GO neither disturbs blood flow even in the narrowest capillaries nor triggers a toxic influence in surrounding cells. Thus, it can be a serious candidate for drugs and biomolecule carriers administered systemically.

Biomedical Applications of Electrospun Graphene Oxide

2021 ◽  
Vol 7 (4) ◽  
pp. 1278-1301 ◽  
Author(s):  
Jamie J. Grant ◽  
Suresh C. Pillai ◽  
Sarah Hehir ◽  
Marion McAfee ◽  
Ailish Breen
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications

Improved dispersibility of nano-graphene oxide by amphiphilic polymer coatings for biomedical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77818-77829 ◽  
Author(s):  
Rana Imani ◽  
Wei Shao ◽  
Shahriar Hojjati Emami ◽  
Shahab Faghihi ◽  
Satya Prakash
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Aqueous Media ◽  
Polymer Coatings ◽  
Amphiphilic Polymer ◽  
Nano Materials ◽  
Biological Applications ◽  
The Poor ◽  
Nano Graphene

The poor dispersibility of graphene-based nano-materials in aqueous media is a crucial limitation in their biological applications.

Fluorescent detection of copper(II) based on DNA-templated click chemistry and graphene oxide

Methods ◽  
2013 ◽  
Vol 64 (3) ◽  
pp. 299-304 ◽  
Author(s):  
Lifen Zhou ◽  
Qinpeng Shen ◽  
Peng Zhao ◽  
Bingbing Xiang ◽  
Zhou Nie ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Click Chemistry ◽  
Fluorescent Detection

An efficient method for the synthesis of a polymer brush via click chemistry and its ultrasensitive electrochemical detection of AFP

2018 ◽  
Vol 10 (20) ◽  
pp. 2390-2397 ◽  
Author(s):  
Dongcheng Yang ◽  
Jing Wang ◽  
Hou Chen ◽  
Hui Xu ◽  
Wenxiang Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Click Chemistry ◽  
Tumor Markers ◽  
Electrochemical Detection ◽  
Efficient Method ◽  
Polymer Brush ◽  
Electrochemical Immunosensor ◽  
Ultrasensitive Detection

A sensitive electrochemical immunosensor based on polyacrylonitrile-g-poly(hydroxyethylmethacrylate) (PAN-g-PHEMA)/graphene oxide (GO) composites was prepared for the ultrasensitive detection of tumor markers.

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