Improved dispersibility of nano-graphene oxide by amphiphilic polymer coatings for biomedical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77818-77829 ◽  
Author(s):  
Rana Imani ◽  
Wei Shao ◽  
Shahriar Hojjati Emami ◽  
Shahab Faghihi ◽  
Satya Prakash
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Aqueous Media ◽  
Polymer Coatings ◽  
Amphiphilic Polymer ◽  
Nano Materials ◽  
Biological Applications ◽  
The Poor ◽  
Nano Graphene

The poor dispersibility of graphene-based nano-materials in aqueous media is a crucial limitation in their biological applications.

Recent Advance in Synthesis and Application of Inorganic Glyconanoparticles as Bio-Therapeutics and Diagnostics Agents

2013 ◽  
Vol 754 ◽  
pp. 1-19
Author(s):  
Udayanath Aich
Keyword(s):  
Drug Discovery ◽  
Cellular Uptake ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Inorganic Nanoparticles ◽  
Biological Applications ◽  
Drug Candidates ◽  
The Poor ◽  
Serum Clearance ◽  
High Concentrations

Carbohydrates are attractive molecules for drug discovery because sugars are involved in many intricate human diseases including cancer and infectious diseases. Potential therapeutic and diagnostic benefits of sugar-based drugs, however, are offset by the poor pharmacologic properties of these molecules that include speedy serum clearance, poor cellular uptake, and the relatively high concentrations required for efficacy. To address these issues, carbohydrates are functionalized with nanocarrier as similar to peptides, proteins and DNA. Considering the vast relevance of Inorganic nanoparticles as promising candidates for electronic, optical, magnetic and biomedical applications, several metals linked glyconanoparticles (GNPs) are synthesized and applied for biomedical application. This article will elaborately discuss about the progress in the development of metallic GNPs for various biological applications as drug candidates and detection agents.

Comprehensive Review on Graphene Oxide for Use in Drug Delivery System

2020 ◽  
Vol 27 (22) ◽  
pp. 3665-3685 ◽  
Author(s):  
Muhammad Daniyal ◽  
Bin Liu ◽  
Wei Wang
Keyword(s):  
Graphene Oxide ◽  
Surface Area ◽  
Biomedical Applications ◽  
Drug Transport ◽  
Drug Carrier ◽  
Drug Loading ◽  
Anti Cancer ◽  
Targeted Drug ◽  
Nano Graphene ◽  
High Drug Loading

Motivated by the accomplishment of carbon nanotubes (CNTs), graphene and graphene oxide (GO) has been widely investigated in the previous studies as an innovative medication nanocarrier for the loading of a variety of therapeutics as well as anti-cancer medications, poor dissolvable medications, antibiotics, antibodies, peptides, DNA, RNA and genes. Graphene provides the ultra-high drug-loading efficiency due to the wide surface area. Graphene and graphene oxide have been widely investigated for biomedical applications due to their exceptional qualities: twodimensional planar structure, wide surface area, chemical and mechanical constancy, sublime conductivity and excellent biocompatibility. Due to these unique qualities, GO applications provide advanced drug transports frameworks and transports of a broad range of therapeutics. In this review, we discussed the latest advances and improvements in the uses of graphene and GO for drug transport and nanomedicine. Initially, we have described what is graphene and graphene oxide. After that, we discussed the qualities of GO as a drug carrier, utilization of GO in drug transport applications, targeted drug transport, transport of anticancer medications, chemical control medicine releasee, co-transport of different medications, comparison of GO with CNTs, nano-graphene for drug transport and at last, we have discussed the graphene toxicity. Finally, we draw a conclusion of current expansion and the potential outlook for the future.

scholarly journals Biomedical Applications of Graphene-Based Structures

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 944 ◽  
Author(s):  
Krzysztof Tadyszak ◽  
Jacek Wychowaniec ◽  
Jagoda Litowczenko
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Real Life ◽  
Biological Applications ◽  
Proliferation And Differentiation ◽  
Reduced Forms

Graphene and graphene oxide (GO) structures and their reduced forms, e.g., GO paper and partially or fully reduced three-dimensional (3D) aerogels, are at the forefront of materials design for extensive biomedical applications that allow for the proliferation and differentiation/maturation of cells, drug delivery, and anticancer therapies. Various viability tests that have been conducted in vitro on human cells and in vivo on mice reveal very promising results, which make graphene-based materials suitable for real-life applications. In this review, we will give an overview of the latest studies that utilize graphene-based structures and their composites in biological applications and show how the biomimetic behavior of these materials can be a step forward in bridging the gap between nature and synthetically designed graphene-based nanomaterials.

Biocompatible Flexible Carbon Fabric for Joule Heaters With and Without Graphene Oxide Coating

2021 ◽  
Vol 21 (7) ◽  
pp. 3697-3700
Author(s):  
Do-Hoon Kim ◽  
Jae Hyun Lee ◽  
Seok-Kyun Son ◽  
Ki-Taek Kim
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Research Work ◽  
Infrared Camera ◽  
Oxide Coating ◽  
Nano Materials ◽  
Carbon Fabric ◽  
Electrical Measurements ◽  
Graphene Films

In this study, we demonstrate a carbon-based fabric Joule heater with and without a graphene oxide (GO) thin coating. The electrothermal performance of the carbon fabric used in the Joule heater was obtained using an infrared camera and by conducting electrical measurements. The outer GO could control the electrothermal efficiency and heating rate. In this research work, using the Joule heating of thin graphene films, we report adaptive thermal heating with electrical control covering temperatures ranging 30 to 50 °C (near infrared). This electrothermal GO materials can be potential nano-materials for various functional applications. Moreover, we demonstrate a general approach to achieve spin-coating of GO and confirm its biocompatibility Such biocompatibility indicates the non-toxic nature of GO, thereby extending its possible use in biomedical applications.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

2017 ◽  
Vol 10 (4) ◽  
pp. 3768-3771
Author(s):  
Soumitra Satapathi ◽  
Rutusmita Mishra ◽  
Manisha Chatterjee ◽  
Partha Roy ◽  
Somesh Mohapatra
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Cell ◽  
High Surface ◽  
High Surface Area ◽  
Cancer Cell Line ◽  
Xrd Analysis ◽  
Graphene Derivatives ◽  
Nano Graphene

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

scholarly journals Aloe Vera-Mediated Te Nanostructures: Highly Potent Antibacterial Agents and Moderated Anticancer Effects

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 514
Author(s):  
David Medina-Cruz ◽  
Ada Vernet-Crua ◽  
Ebrahim Mostafavi ◽  
María Ujué González ◽  
Lidia Martínez ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Aqueous Media ◽  
Aloe Vera ◽  
Multidrug Resistant ◽  
Dermal Fibroblasts ◽  
Anticancer Properties ◽  
Green Approach ◽  
Anticancer Effects ◽  
Synthesis Of Nanomaterials ◽  
By Products

Cancer and antimicrobial resistance to antibiotics are two of the most worrying healthcare concerns that humanity is facing nowadays. Some of the most promising solutions for these healthcare problems may come from nanomedicine. While the traditional synthesis of nanomaterials is often accompanied by drawbacks such as high cost or the production of toxic by-products, green nanotechnology has been presented as a suitable solution to overcome such challenges. In this work, an approach for the synthesis of tellurium (Te) nanostructures in aqueous media has been developed using aloe vera (AV) extracts as a unique reducing and capping agent. Te-based nanoparticles (AV-TeNPs), with sizes between 20 and 60 nm, were characterized in terms of physicochemical properties and tested for potential biomedical applications. A significant decay in bacterial growth after 24 h was achieved for both Methicillin-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli at a relative low concentration of 5 µg/mL, while there was no cytotoxicity towards human dermal fibroblasts after 3 days of treatment. AV-TeNPs also showed anticancer properties up to 72 h within a range of concentrations between 5 and 100 µg/mL. Consequently, here, we present a novel and green approach to produce Te-based nanostructures with potential biomedical applications, especially for antibacterial and anticancer applications.

scholarly journals A New Approach to Obtaining Nano-Sized Graphene Oxide for Biomedical Applications

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1327
Author(s):  
Paulina Bolibok ◽  
Bartosz Szymczak ◽  
Katarzyna Roszek ◽  
Artur P. Terzyk ◽  
Marek Wiśniewski
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Effective Concentration ◽  
New Approach ◽  
Spectral Changes ◽  
Dimethyl Sulfoxide Solution ◽  
Aggregation Processes ◽  
Initial Oxygen ◽  
Half Maximal Effective Concentration ◽  
Nano Size

Graphene oxide (GO) is one of the most exciting and widely used materials. A new method of nanographene oxide (n-GO) formation is presented. The described unique sequence of ultrasonication in dimethyl sulfoxide solution allows us to obtain different sizes of n-GO sheets by controlling the timing of the cutting and re-aggregation processes. The obtained n-GO exhibits only minor spectral changes, mainly due to the formation of S-containing surface groups; thus, it can be concluded that the material is not reduced during the process. Maintaining the initial oxygen functionalities together with the required nano-size (down to 200 nm) and high homogeneity are beneficial for extensive applications of n-GO. Moreover, we prove that the obtained material is evidently biocompatible. The calculated half-maximal effective concentration (EC50) increases by 5-fold, i.e., from 50 to 250 µg/mL, when GO is converted to n-GO. As a consequence, the new n-GO neither disturbs blood flow even in the narrowest capillaries nor triggers a toxic influence in surrounding cells. Thus, it can be a serious candidate for drugs and biomolecule carriers administered systemically.

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