Lack of association of IRF5 gene polymorphisms with autoimmune thyroid disease: A case-control study. IRF5 gene and AITD

2014 ◽  
Vol 75 (1) ◽  
pp. 19-24
Author(s):  
Fatuma-Said Muhali ◽  
Zhen Zhou-jiao ◽  
Yuan Wang ◽  
Qiong Wang ◽  
Xiao-hong Shi ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Case Control ◽  
Autoimmune Thyroid ◽  
Control Study

scholarly journals Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

2012 ◽  
Vol 130 (5) ◽  
pp. 294-298 ◽  
Author(s):  
Ruy Felippe Brito Gonçalves Missaka ◽  
Henrique Costa Penatti ◽  
Maria Regina Cavariani Silvares ◽  
Célia Regina Nogueira ◽  
Gláucia Maria Ferreira da Silva Mazeto
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Thyroid Autoimmunity ◽  
Case Control ◽  
Chronic Idiopathic Urticaria ◽  
Public Institution ◽  
Autoimmune Thyroid ◽  
Allergic Condition ◽  
Control Study

CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS: The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%). There were 22 cases (19.1%) of ATD, 19 (16.5%) of hypothyroidism and nine (7.8%) of hyperthyroidism. The risk among patients with ATD was 16.2 times greater than among those without this thyroid abnormality (confidence interval, CI = 2.07-126.86). The odds ratio for hypothyroidism was 4.6 (CI = 1.00-21.54) and, for hyperthyroidism, 3.3 (CI = 0.38-28.36). CONCLUSIONS: Patients with CIU and ATD presented greater risk of angioedema, which reinforces the idea that a relationship exists between this allergic condition and thyroid autoimmunity. This finding could imply that such patients require specifically directed therapy.

Frequency of rheumatoid arthritis in patients with autoimmune thyroid disease: a case–control study

2018 ◽  
Vol 4 (1) ◽  
pp. 5 ◽  
Author(s):  
KhaledN Elfayoumy ◽  
HafezA Abd-Elhafeez ◽  
El-Sayed El-Meghawry ◽  
Sabry Al-Azhary ◽  
Tarek Emran ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Case Control ◽  
Autoimmune Thyroid ◽  
Control Study

scholarly journals Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0220858 ◽  
Author(s):  
Ryosuke Tashiro ◽  
Kuniyasu Niizuma ◽  
Seik-Soon Khor ◽  
Katsushi Tokunaga ◽  
Miki Fujimura ◽  
...  
Keyword(s):  
Moyamoya Disease ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Risk Allele ◽  
Case Control ◽  
Autoimmune Thyroid ◽  
Control Study

Autoimmune thyroid disease, genetic predisposition and environment – case-control and family studies

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
M Meilinger ◽  
N Schweighofer ◽  
A Forjanics ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Genetic Predisposition ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Family Studies ◽  
Case Control ◽  
Autoimmune Thyroid

scholarly journals Genetic association of TOLLIP gene polymorphisms and HIV infection: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ming-Gui Wang ◽  
Jing Wang ◽  
Jian-Qing He
Keyword(s):  
Hiv Infection ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Case Control ◽  
Additive Models ◽  
Chinese Han ◽  
Interacting Protein ◽  
Control Study ◽  
Age And Sex

Abstract Background Previous studies have indicated that host genetic factors play an essential role in immunity to human immunodeficiency virus (HIV) infection. We aimed to investigate the association between the toll-interacting protein (TOLLIP) and mannose-binding lectin 2 (MBL2) genes and HIV infection susceptibility among Chinese Han patients. Methods This is a case-control study. A total of 435 HIV-infected patients and 1013 seronegative healthy individuals were recruited. DNA was extracted from whole blood. Two SNPs in the MBL2 gene (rs7096206 and rs1800450) and three SNPs in the TOLLIP gene (rs5743899, rs3750920, and rs5743867) were selected and genotyped using a SNPscan Kit (Cat#: G0104, Genesky Biotechnologies Inc., Shanghai, China). Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using unconditional binary logistic regression. Results A significant association between the minor alleles rs5743899 (C allele) and rs5743867 (G allele) in the TOLLIP gene and susceptibility to HIV infection was found in this study after adjusting for age and sex (Pa = 0.011 and < 0.001, respectively). The rs5743867 in the TOLLIP gene was significantly associated with the risk of HIV infection in dominant, recessive, and additive models when adjusted for age and sex (Pa < 0.05). No significant association was found between MBL2 gene polymorphisms and HIV infection. Conclusion Our study found a statistically significant association between the two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population.

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