Frequency of rheumatoid arthritis in patients with autoimmune thyroid disease: a case–control study

2018 ◽  
Vol 4 (1) ◽  
pp. 5 ◽  
Author(s):  
KhaledN Elfayoumy ◽  
HafezA Abd-Elhafeez ◽  
El-Sayed El-Meghawry ◽  
Sabry Al-Azhary ◽  
Tarek Emran ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Case Control ◽  
Autoimmune Thyroid ◽  
Control Study

scholarly journals Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

2012 ◽  
Vol 130 (5) ◽  
pp. 294-298 ◽  
Author(s):  
Ruy Felippe Brito Gonçalves Missaka ◽  
Henrique Costa Penatti ◽  
Maria Regina Cavariani Silvares ◽  
Célia Regina Nogueira ◽  
Gláucia Maria Ferreira da Silva Mazeto
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Thyroid Autoimmunity ◽  
Case Control ◽  
Chronic Idiopathic Urticaria ◽  
Public Institution ◽  
Autoimmune Thyroid ◽  
Allergic Condition ◽  
Control Study

CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS: The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%). There were 22 cases (19.1%) of ATD, 19 (16.5%) of hypothyroidism and nine (7.8%) of hyperthyroidism. The risk among patients with ATD was 16.2 times greater than among those without this thyroid abnormality (confidence interval, CI = 2.07-126.86). The odds ratio for hypothyroidism was 4.6 (CI = 1.00-21.54) and, for hyperthyroidism, 3.3 (CI = 0.38-28.36). CONCLUSIONS: Patients with CIU and ATD presented greater risk of angioedema, which reinforces the idea that a relationship exists between this allergic condition and thyroid autoimmunity. This finding could imply that such patients require specifically directed therapy.

scholarly journals Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0220858 ◽  
Author(s):  
Ryosuke Tashiro ◽  
Kuniyasu Niizuma ◽  
Seik-Soon Khor ◽  
Katsushi Tokunaga ◽  
Miki Fujimura ◽  
...  
Keyword(s):  
Moyamoya Disease ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Risk Allele ◽  
Case Control ◽  
Autoimmune Thyroid ◽  
Control Study

Lack of association of IRF5 gene polymorphisms with autoimmune thyroid disease: A case-control study. IRF5 gene and AITD

2014 ◽  
Vol 75 (1) ◽  
pp. 19-24
Author(s):  
Fatuma-Said Muhali ◽  
Zhen Zhou-jiao ◽  
Yuan Wang ◽  
Qiong Wang ◽  
Xiao-hong Shi ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Case Control Study ◽  
Case Control ◽  
Autoimmune Thyroid ◽  
Control Study

THU0051 Autoinmune thyroid disease in patients with rheumatoid arthritis: Case – control study

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 170.2-170
Author(s):  
R. Gomez ◽  
J.M. Gutierrez ◽  
D.G. Fernandez-Avila ◽  
M.C. Diaz ◽  
P. Aschner
Keyword(s):  
Rheumatoid Arthritis ◽  
Thyroid Disease ◽  
Case Control Study ◽  
Case Control ◽  
Rheumatoid Arthritis Case ◽  
Control Study

Autoimmune thyroid disease, genetic predisposition and environment – case-control and family studies

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
M Meilinger ◽  
N Schweighofer ◽  
A Forjanics ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Genetic Predisposition ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Family Studies ◽  
Case Control ◽  
Autoimmune Thyroid

Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study

2018 ◽  
Vol 13 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Francesco Ursini ◽  
Salvatore D`Angelo ◽  
Emilio Russo ◽  
Giorgio Ammerata ◽  
Ludovico Abenavoli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Complement C3 ◽  
Serum Complement ◽  
Control Study

scholarly journals SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 973-973
Author(s):  
R. Gonzalez Mazario ◽  
J. J. Fragio-Gil ◽  
P. Martinez Calabuig ◽  
E. Grau García ◽  
M. De la Rubia Navarro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Disease Duration ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Carotid Ultrasonography ◽  
Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics

2014 ◽  
Vol 60 (2-3) ◽  
pp. 193-200 ◽  
Author(s):  
Ivica Lazúrová ◽  
Ivana Jochmanová ◽  
Karim Benhatchi ◽  
Štefan Sotak
Keyword(s):  
Rheumatoid Arthritis ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid
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