scholarly journals Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush

2017 ◽  
Vol 187 (2) ◽  
pp. 352-365 ◽  
Author(s):  
Yonju Ha ◽  
Hua Liu ◽  
Shuang Zhu ◽  
Panpan Yi ◽  
Wei Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuropathy ◽  
Chemokine Receptor ◽  
Critical Role ◽  
Neuronal Injury ◽  
Leukocyte Recruitment ◽  
Optic Nerve Crush ◽  
Traumatic Optic Neuropathy ◽  
Nerve Crush

The expression and role of PIDD in retina after optic nerve crush

2020 ◽  
Vol 51 (1) ◽  
pp. 89-97
Author(s):  
Fen Tang ◽  
Fan Xu ◽  
Ling Cui ◽  
Wei Huang ◽  
Li Jiang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Nerve Crush

scholarly journals The Susceptibility of Retinal Ganglion Cells to Optic Nerve Injury is Type Specific

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 677 ◽  
Author(s):  
Ning Yang ◽  
Brent K Young ◽  
Ping Wang ◽  
Ning Tian
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Survival Rates ◽  
Dependent Manner ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Optic Nerve Injury ◽  
Traumatic Optic Neuropathy ◽  
Nerve Crush

Retinal ganglion cell (RGC) death occurs in many eye diseases, such as glaucoma and traumatic optic neuropathy (TON). Increasing evidence suggests that the susceptibility of RGCs varies to different diseases in an RGC type-dependent manner. We previously showed that the susceptibility of several genetically identified RGC types to N-methyl-D-aspartate (NMDA) excitotoxicity differs significantly. In this study, we characterize the susceptibility of the same RGC types to optic nerve crush (ONC). We show that the susceptibility of these RGC types to ONC varies significantly, in which BD-RGCs are the most resistant RGC type while W3-RGCs are the most sensitive cells to ONC. We also show that the survival rates of BD-RGCs and J-RGCs after ONC are significantly higher than their survival rates after NMDA excitotoxicity. These results are consistent with the conclusion that the susceptibility of RGCs to ONC varies in an RGC type-dependent manner. Further, the susceptibilities of the same types of RGCs to ONC and NMDA excitotoxicity are significantly different. These are valuable insights for understanding of the selective susceptibility of RGCs to various pathological insults and the development of a strategy to protect RGCs from death in disease conditions.

A study of role of VEP in traumatic optic neuropathy

2019 ◽  
Vol 11 (2) ◽  
pp. 40-41
Author(s):  
G Thiruvengada Senthil Kumar ◽  
◽  
L Feroz Ahamed ◽  
Keyword(s):  
Optic Neuropathy ◽  
Traumatic Optic Neuropathy

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hong Ryul Ahn ◽  
Kyung-A Kim ◽  
Suk Woo Kang ◽  
Joo Young Lee ◽  
Tae-Jin Kim ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Degeneration ◽  
Diospyros Kaki ◽  
Optic Nerve Crush ◽  
Nerve Crush
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